{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLung adenocarcinoma (LUAD), a predominant subtype of non‐small cell lung cancer, exhibits significant upregulation of the long non-coding RNA PRKCZ-AS1 in both tumor tissues and cell lines. Functional studies reveal that silencing PRKCZ-AS1 impairs LUAD cell proliferation and migration while inducing apoptosis. Mechanistically, PRKCZ-AS1 acts as a molecular sponge for miR-766-5p, thereby suppressing its expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In addition, the sequestration of miR-766-5p by PRKCZ-AS1 results in the upregulation of MAPK1, a key mediator involved in cell growth and migration. The direct binding between miR-766-5p and MAPK1 was confirmed, and further experiments demonstrated that MAPK1 knockdown could partially offset the enhanced proliferation and migration induced by reduced miR-766-5p in the context of high PRKCZ-AS1 expression. These findings suggest that the PRKCZ-AS1/miR-766-5p/MAPK1 regulatory axis plays a critical role in LUAD progression, offering promising new avenues for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ming Wang, Qin Liao, Pengfei Zou "}, {"type": "b", "children": [{"type": "t", "text": "PRKCZ-AS1 promotes the tumorigenesis of lung adenocarcinoma via sponging miR-766-5p to modulate MAPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2019.1702402"}], "href": "https://doi.org/10.1080/15384047.2019.1702402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31939714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31939714"}]}]}]}