| Name | proline rich 20A |
| Description | This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch into developmentally relevant proteins has highlighted distinct molecular roles that impact embryonic cell fate and craniofacial morphogenesis. On one hand, work in mouse embryonic stem cells has revealed that the WD‐40 repeat protein PWP1 plays a critical role in the exit from pluripotency by modulating chromatin structure. PWP1 is localized at regions enriched in histone H4K20me3 and occupies sites upstream of the Stat3 gene; by maintaining these repressive marks, it suppresses Stat3 expression. Knockdown of Pwp1 does not alter proliferation, self‐renewal, or apoptosis, but it compromises the differentiation potential of the cells, an effect that can be reversed by dampening Stat3 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn a separate line of investigation, a mutation screening study focusing on the poliovirus receptor related‐2 (PRR2) gene—a locus mapped to an orofacial cleft linkage region—has suggested an etiologic role in nonsyndromic cleft lip with or without cleft palate. A significant association was identified between the PRR2 Sau96I (A/G) polymorphism and the risk of developing orofacial clefts, with the GG genotype and the G allele conferring an increased risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junwei Shen, Wenwen Jia, Yangyang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.1876"}], "href": "https://doi.org/10.1002/stem.1876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25335925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25335925"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huang Chengle, Ding Kaihong, Ban Fuzhi "}, {"type": "b", "children": [{"type": "t", "text": "Association analysis of the poliovirus receptor related-2 gene in patients with nonsyndromic cleft lip with or without cleft palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2010.1061"}], "href": "https://doi.org/10.1089/dna.2010.1061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20662561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20662561"}]}]}]}
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| Synonyms | PRR20E, PRR20 |
| Proteins | PR20A_HUMAN |
| NCBI Gene ID | 122183 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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PRR20A has 482 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.
Click the + buttons to view associations for PRR20A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PRR20A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRR20A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRR20A gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PRR20A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PRR20A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PRR20A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PRR20A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PRR20A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PRR20A gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRR20A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PRR20A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with PRR20A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of PRR20A protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PRR20A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PRR20A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRR20A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PRR20A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of PRR20A gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PRR20A gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PRR20A gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PRR20A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
