{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that lncRNA PRRT3‑AS1 plays a pivotal role in the regulation of cancer cell behavior. In prostate cancer, for example, silencing PRRT3‑AS1 was found to upregulate apoptosis and autophagy while downregulating proliferation, migration, and invasion via modulation of the peroxisome proliferator‑activated receptor γ (PPARγ)‑mediated mechanistic target of rapamycin (mTOR) signalling pathway. This finding suggests that targeting PRRT3‑AS1 could offer a promising therapeutic avenue for managing prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of skin cutaneous melanoma (SKCM), integrated analyses of single‑cell and bulk RNA sequencing data have identified PRRT3‑AS1 among a panel of prognostic long non‑coding RNAs. Although the underlying mechanisms in melanoma remain to be fully elucidated, its identification as a potential biomarker underlines the importance of PRRT3‑AS1 in the diagnosis and prognosis of this aggressive cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in non‑small cell lung cancer (NSCLC), elevated levels of PRRT3‑AS1 have been associated with increased cellular proliferation, colony formation, invasion, and migration. Mechanistic investigations revealed that PRRT3‑AS1 functions as a competing endogenous RNA by sequestering microRNA‑507, thereby upregulating the expression of HOXB5—a pathway that significantly contributes to the malignancy and progression of NSCLC. These insights provide a strong rationale for considering the PRRT3‑AS1/miR‑507/HOXB5 axis as a potential diagnostic, prognostic, and therapeutic target in lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Fan, Hai Li, Weihua Wang "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA PRRT3-AS1 silencing inhibits prostate cancer cell proliferation and promotes apoptosis and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/EP088011"}], "href": "https://doi.org/10.1113/EP088011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32086850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32086850"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wancong Zhang, Xuqi Xie, Zijian Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The integration of single-cell sequencing, TCGA, and GEO data analysis revealed that PRRT3-AS1 is a biomarker and therapeutic target of SKCM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.919145"}], "href": "https://doi.org/10.3389/fimmu.2022.919145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36211371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36211371"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rui Zhou, Jianyang Xu, Lingwei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PRRT3-AS1 exerts oncogenic effects on nonsmall cell lung cancer by targeting microRNA-507/homeobox B5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.32604/or.2022.026236"}], "href": "https://doi.org/10.32604/or.2022.026236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37304647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37304647"}]}]}]}