PRSS50 Gene

HGNC Family Proteases, serine (PRSS)
Name protease, serine, 50
Description Enables threonine-type endopeptidase activity. Involved in proteolysis. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTestes‐specific protease 50 (PRSS50), also known as TSP50, was originally identified as a gene normally expressed in spermatocytes, and its product exhibits structural homology to serine proteases despite possessing threonine in its catalytic site. Its expression is subject to epigenetic and transcriptional regulation, as studies have shown that DNA methylation status and promoter elements—such as Sp1 and C/EBP binding sites—modulate its basal transcription in normal testicular tissue compared to malignant tissues. These findings established TSP50 as a cancer/testis antigen with a unique enzymatic profile."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulated expression of PRSS50 has been documented in a wide variety of cancers—including breast, cervical, gastric, non‐small cell lung, and laryngocarcinoma—where its overexpression is consistently linked to enhanced tumor cell proliferation, migration, invasion, and metastatic progression. Functional studies have demonstrated that TSP50’s protease activity is integral to its oncogenic role; catalytic triad mutations impair its capacity to activate key mitogenic pathways, suggesting that cleavage events (such as the proteolytic targeting of IκBα) lead to aberrant NF‑κB signaling. Moreover, knockdown experiments in multiple cell line models have underscored its importance in driving cell cycle progression and diminishing apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, PRSS50 exerts its tumor‐promoting functions through several interrelated pathways. It is negatively regulated by basic fibroblast growth factor (bFGF) via ERK‐mediated phosphorylation of Sp1, and its overexpression has been shown to inhibit activin signaling—thereby reducing p27 expression and further promoting cell proliferation. In hepatocellular carcinoma, TSP50 interacts with pyruvate kinase M2 (PKM2) to increase its K433 acetylation, leading to a low pyruvate kinase activity that favors the Warburg effect. Additionally, the gene is subject to posttranscriptional regulation by microRNAs (for example, miR-4709-3p has been shown to directly target the TSP50 3’-UTR reducing its protein levels), and novel therapeutic compounds have emerged that downregulate TSP50 expression in preclinical cancer models. Elevated TSP50 expression also correlates with adverse clinicopathological features and poorer prognosis in colorectal and other cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jidong Shan, Liming Yuan, Qianxun Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11782390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11782390"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hao-Peng Xu, Liming Yuan, Jidong Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Localization and expression of TSP50 protein in human and rodent testes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urology.2004.05.012"}], "href": "https://doi.org/10.1016/j.urology.2004.05.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15491742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15491742"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Huang, Yuezeng Wang, Miao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.07.087"}], "href": "https://doi.org/10.1016/j.bbrc.2008.07.087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18662669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18662669"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Miao Wang, Yong Li Bao, Yin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the human testes-specific protease 50 gene promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2007.0692"}], "href": "https://doi.org/10.1089/dna.2007.0692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18462069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18462069"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu-Yin Li, Yong-Li Bao, Zhen-Bo Song, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2014.07.012"}], "href": "https://doi.org/10.1016/j.cellsig.2014.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25049081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25049081"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaopeng Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Depression of testes-specific protease 50 (TSP50) inhibits cell proliferation and induces apoptosis in laryngocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2090-y"}], "href": "https://doi.org/10.1007/s13277-014-2090-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25077921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25077921"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jing Yuan, ChunFeng Wu, MingLi Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSP50 depends on its threonine protease activity and its interactions with TNF-α-induced NF-κB for its role in human cervical tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-014-0279-8"}], "href": "https://doi.org/10.1007/s12013-014-0279-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25312478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25312478"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yu-Lin Liu, Ya-Nan Sun "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of testes-specific protease 50 induces apoptosis in human laryngocarcinoma HEp2 cells in a NF-κB-mediated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-014-3634-3"}], "href": "https://doi.org/10.1007/s11033-014-3634-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25399078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25399078"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Z B Song, J-S Ni, P Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2015.61"}], "href": "https://doi.org/10.1038/cddis.2015.61"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25811800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25811800"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wen-Liang Qiao, Hai-Yang Hu, Bo-Wen Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lentivirus-mediated knockdown of TSP50 suppresses the growth of non-small cell lung cancer cells via G0/G1 phase arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4763"}], "href": "https://doi.org/10.3892/or.2016.4763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27109614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27109614"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Miao Wang, Yong-Li Bao, Yin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Basic FGF downregulates TSP50 expression via the ERK/Sp1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22664"}], "href": "https://doi.org/10.1002/jcb.22664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20506264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20506264"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Danfeng Wang, Yuqing Zhao, Yimeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "25-methoxyl-dammarane-3β, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation through downregulation of testes-specific protease 50 (TSP50) expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5037-7"}], "href": "https://doi.org/10.1007/s13277-016-5037-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27039397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27039397"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "N R Hilal, D V Novikov, V V Novikov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Cancer-testis genes in colon cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ter Arkh (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17116/terarkh2017895113-117"}], "href": "https://doi.org/10.17116/terarkh2017895113-117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28631709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28631709"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Z-B Song, P Wu, J-S Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.198"}], "href": "https://doi.org/10.1038/onc.2017.198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28650473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28650473"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qing-Hua Cao, Fang Liu, Chang-Zhao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-4000-y"}], "href": "https://doi.org/10.1186/s12885-018-4000-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29361914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29361914"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiaojun Zhang, Feng Gao, Huihan Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.13015"}], "href": "https://doi.org/10.1111/cpr.13015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33630390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33630390"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ying Wang, Shifeng Xu, Shuyue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4709-3p Inhibits Cell Proliferation by Downregulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TSP50"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Expression in Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2020.6260"}], "href": "https://doi.org/10.1089/dna.2020.6260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33956530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33956530"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Feng Gao, Xiaojun Zhang, Shuyue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03782-w"}], "href": "https://doi.org/10.1038/s41419-021-03782-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34016961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34016961"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Heba M K Youssef, Dina A Radi, Marwa A Abd El-Azeem "}, {"type": "b", "children": [{"type": "t", "text": "Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/pore.2021.1609990"}], "href": "https://doi.org/10.3389/pore.2021.1609990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34744521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34744521"}]}]}]}
Synonyms TSP50, CT20
Proteins TSP50_HUMAN
NCBI Gene ID 29122
API
Download Associations
Predicted Functions View PRSS50's ARCHS4 Predicted Functions.
Co-expressed Genes View PRSS50's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PRSS50's ARCHS4 Predicted Functions.

Functional Associations

PRSS50 has 3,535 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 79 datasets.

Click the + buttons to view associations for PRSS50 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PRSS50 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of PRSS50 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of PRSS50 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of PRSS50 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PRSS50 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of PRSS50 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PRSS50 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PRSS50 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PRSS50 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of PRSS50 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with PRSS50 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRSS50 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of PRSS50 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of PRSS50 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRSS50 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing PRSS50 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing PRSS50 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with PRSS50 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with PRSS50 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of PRSS50 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with PRSS50 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with PRSS50 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by PRSS50 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with PRSS50 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with PRSS50 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with PRSS50 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with PRSS50 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PRSS50 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRSS50 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PRSS50 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing PRSS50 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of PRSS50 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with PRSS50 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing PRSS50 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of PRSS50 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PRSS50 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of PRSS50 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRSS50 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of PRSS50 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of PRSS50 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving PRSS50 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving PRSS50 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving PRSS50 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing PRSS50 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by PRSS50 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by PRSS50 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by PRSS50 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of PRSS50 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of PRSS50 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PRSS50 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of PRSS50 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of PRSS50 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PRSS50 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for PRSS50 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PRSS50 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PRSS50 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PRSS50 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of PRSS50 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain PRSS50 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by PRSS50 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting PRSS50 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of PRSS50 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by PRSS50 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of PRSS50 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NURSA Protein Complexes protein complexs containing PRSS50 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for PRSS50 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of PRSS50 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of PRSS50 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PRSS50 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of PRSS50 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of PRSS50 gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of PRSS50 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PRSS50 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PRSS50 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of PRSS50 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PRSS50 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of PRSS50 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with PRSS50 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with PRSS50 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.