PRY Gene

Name PTPN13-like, Y-linked
Description This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Aug 2024]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe UPF0224 protein family, which includes the members Gtsf1, Gtsf1l, and Gtsf2, is expressed in mouse germ‐line cells and is characterized by an N‐terminal region containing two CHHC Zn‐finger motifs, a feature that suggests RNA‐binding capabilities. Previous studies established that Gtsf1 is critical for normal spermatogenesis and the suppression of retrotransposon activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDissecting the roles of the other family members, the study found that Gtsf1l and Gtsf2 are expressed sequentially—Gtsf1l being prominent in gonocytes and Gtsf2 in spermatids—implying stagespecific roles during germ cell development. Both proteins were also shown to interact with PIWI‐protein complexes, hinting at potential involvement in the piRNA pathway typically associated with genomic integrity in germ cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDespite these interactions and expression patterns, knockout experiments targeting Gtsf1l and Gtsf2—either individually or in combination with Gtsf1 disruption—did not result in impairments in spermatogenesis or retrotransposon suppression. This suggests that while these proteins, and by extension the PRY domain‐containing elements they comprise, may contribute to the network of RNA‐regulated processes in germ cells, they are likely to be functionally redundant or not strictly essential for these particular aspects of germ-line development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Noriaki Takemoto, Takuji Yoshimura, Satsuki Miyazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0150390"}], "href": "https://doi.org/10.1371/journal.pone.0150390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26930067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26930067"}]}]}]}
Synonyms PRY1, PTPN13LY
Proteins PRY_HUMAN
NCBI Gene ID 9081
API
Download Associations
Predicted Functions View PRY's ARCHS4 Predicted Functions.
Co-expressed Genes View PRY's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PRY's ARCHS4 Predicted Functions.

Functional Associations

PRY has 683 functional associations with biological entities spanning 6 categories (molecular profile, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 26 datasets.

Click the + buttons to view associations for PRY from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of PRY gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of PRY gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PRY gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRY gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
DisGeNET Gene-Disease Associations diseases associated with PRY gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRY gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PRY gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of PRY gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of PRY gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PRY gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of PRY gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRY gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of PRY gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of PRY gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of PRY gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of PRY gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of PRY protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for PRY from the curated Hub Proteins Protein-Protein Interactions dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PRY gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PRY gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PRY gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of PRY gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
MiRTarBase microRNA Targets microRNAs targeting PRY gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of PRY gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving PRY protein from the PFOCR Pathway Figure Associations 2023 dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PRY gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.