{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn influenza virus–infected human lung epithelial cells, the long non‐coding RNA (lncRNA) PSMB8‐AS1 is markedly induced by type I interferon signaling and other viral strains. Functional experiments using CRISPR interference demonstrated that repression of PSMB8‐AS1 significantly reduces viral mRNA and protein levels as well as decreases the release of progeny virus, suggesting that PSMB8‐AS1 acts as a pro‐viral host factor that supports efficient influenza virus replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioma, PSMB8‐AS1 is similarly upregulated, where its elevated expression promotes cell proliferation. Mechanistically, PSMB8‐AS1 functions as a competing endogenous RNA by binding to miR‐574–5p, thereby relieving repression of its target gene RAB10. Additionally, transcription factor ELK1 is shown to activate PSMB8‐AS1 expression, further linking it to glioma oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of pancreatic cancer, PSMB8‐AS1 has been found to be dysregulated, although its precise functions and regulatory mechanisms remain largely unclear. This highlights an area for further investigation into how PSMB8‐AS1 may contribute to tumorigenesis in pancreatic tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, transcriptomic and co‐expression network analyses in monocytes from patients with systemic sclerosis identify PSMB8‐AS1 as a top-ranking hub gene associated with cell activation and responses to viral as well as external stimuli. Functional characterization in these immune cells revealed that PSMB8‐AS1 modulates the secretion of key proinflammatory cytokines such as IL-6 and TNFα, implying that it may play an important role in driving inflammatory responses and potentially contributing to disease pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sunil More, Zhengyu Zhu, Kong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA PSMB8-AS1 regulates influenza virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2019.1572448"}], "href": "https://doi.org/10.1080/15476286.2019.1572448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30669933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30669933"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gang Shen, Yuhang Mao, Zuopeng Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109658"}], "href": "https://doi.org/10.1016/j.biopha.2019.109658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31812014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31812014"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hao Zhang, Changhao Zhu, Zhiwei He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01687-8"}], "href": "https://doi.org/10.1186/s13046-020-01687-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32891166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32891166"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nila H Servaas, Barbara Mariotti, Maarten van der Kroef, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Long Non-Coding RNAs in Systemic Sclerosis Monocytes: A Potential Role for PSMB8-AS1 in Altered Cytokine Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22094365"}], "href": "https://doi.org/10.3390/ijms22094365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33922041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33922041"}]}]}]}