PSMD14 Gene

HGNC Family	Proteasome (prosome, macropain) subunits (PSM)
Name	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Description	This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPSMD14 is a critical deubiquitinating enzyme that forms an integral part of the 19S regulatory particle of the 26S proteasome. By removing polyubiquitin chains from target proteins, PSMD14 facilitates their access to the proteolytic 20S core, thereby sustaining overall protein homeostasis. Its intrinsic zinc metalloprotease (JAMM/MPN+) motif is indispensable for proteasomal function, as evidenced by studies showing that disruption of this catalytic site leads to impaired substrate degradation, cell‐cycle arrest, and even multidrug resistance in certain contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in proteolysis, PSMD14 exerts multifaceted control over oncogenic signaling networks by deubiquitinating and thereby stabilizing key regulators. It modulates the DNA double‐strand break response through processing of lysine 63–linked ubiquitin conjugates, while also promoting tumor cell survival via stabilization of transcription factors such as E2F1. PSMD14’s activity supports oncogenic cascades in liver, breast, and other cancers by maintaining the steady-state levels of pivotal proteins including GRB2 and by regulating epithelial–mesenchymal transition (EMT) through deubiquitination of factors like SNAIL. In melanoma, for instance, its function correlates with enhanced invasiveness and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these well‐established roles, emerging evidence indicates that PSMD14 also partakes in non‐canonical cellular processes that contribute to tumor progression and therapeutic resistance. Its regulation extends to intracellular trafficking—where inhibition of PSMD14 disrupts Golgi–endoplasmic reticulum retrograde transport and autophagosome formation—as well as to metabolic reprogramming via control of key enzymes like PKM2. Moreover, PSMD14 modulates the stability of RNA‐binding proteins (e.g. PTBP1), supports stemness and chemoresistance in head and neck cancers, and is implicated in the regulation of non‐apoptotic cell death (paraptosis) and endocrine resistance through stabilization of proteins such as ERα, MYC, Smad3, and even the mitochondrial fission regulator Drp1. Collectively, these studies not only highlight the diverse and context‐dependent functions of PSMD14 in cancer biology but also underscore its promise as a druggable target across a broad spectrum of malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joseph F Nabhan, Paula Ribeiro "}, {"type": "b", "children": [{"type": "t", "text": "The 19 S proteasomal subunit POH1 contributes to the regulation of c-Jun ubiquitination, stability, and subcellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512086200"}], "href": "https://doi.org/10.1074/jbc.M512086200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16569633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16569633"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Melissa Gallery, Jonathan L Blank, Yinghui Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The JAMM motif of human deubiquitinase Poh1 is essential for cell viability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-06-0542"}], "href": "https://doi.org/10.1158/1535-7163.MCT-06-0542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17237285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17237285"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eric M Cooper, Colleen Cutcliffe, Troels Z Kristiansen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2009.27"}], "href": "https://doi.org/10.1038/emboj.2009.27"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19214193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19214193"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zuxiang Ma, Xiaojie Gao, Weiling Zhao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.08.018"}], "href": "https://doi.org/10.1016/j.yexcr.2009.08.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19732767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19732767"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Laura R Butler, Ruth M Densham, Junying Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2012.232"}], "href": "https://doi.org/10.1038/emboj.2012.232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22909820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22909820"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Boshi Wang, Aihui Ma, Li Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.10.025"}], "href": "https://doi.org/10.1016/j.canlet.2019.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31634528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31634528"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Satoru Yokoyama, Yusuke Iwakami, Zhao Hang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting PSMD14 inhibits melanoma growth through SMAD3 stabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-76373-y"}], "href": "https://doi.org/10.1038/s41598-020-76373-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33154524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33154524"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hianara A Bustamante, Karina Cereceda, Alexis E González, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.13076"}], "href": "https://doi.org/10.1002/1878-0261.13076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34382324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34382324"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hong-Jae Lee, Dong-Min Lee, Min-Ji Seo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2022.110490"}], "href": "https://doi.org/10.1016/j.cellsig.2022.110490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36241058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36241058"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zitong Zhao, Heyang Xu, Yuan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2022.166594"}], "href": "https://doi.org/10.1016/j.bbadis.2022.166594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36328147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36328147"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Changxin Jia, Xin Zhang, Tingting Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.14654"}], "href": "https://doi.org/10.7717/peerj.14654"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36632137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36632137"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Tiantian Jing, Xiaoli Xu, Chengsi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2023.216444"}], "href": "https://doi.org/10.1016/j.canlet.2023.216444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37844756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37844756"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Wei Song, Zhuo Li, Ming Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2023.8665"}], "href": "https://doi.org/10.3892/or.2023.8665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37975230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37975230"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Penghe Yang, Xiao Yang, Dehai Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-023-02905-1"}], "href": "https://doi.org/10.1038/s41388-023-02905-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38017133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38017133"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yang Yuan, Yixiao Li, Xiao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2023.216526"}], "href": "https://doi.org/10.1016/j.canlet.2023.216526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38061486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38061486"}]}]}]}
Synonyms	POH1, RPN11, PAD1
Proteins	PSDE_HUMAN
NCBI Gene ID	10213
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PSMD14 has 9,172 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 127 datasets.

Click the + buttons to view associations for PSMD14 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PSMD14 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PSMD14 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSMD14 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSMD14 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PSMD14 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PSMD14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PSMD14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSMD14 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PSMD14 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PSMD14 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSMD14 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSMD14 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PSMD14 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSMD14 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PSMD14 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PSMD14 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PSMD14 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSMD14 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PSMD14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PSMD14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PSMD14 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PSMD14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PSMD14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PSMD14 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PSMD14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PSMD14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PSMD14 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSMD14 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PSMD14 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PSMD14 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PSMD14 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PSMD14 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PSMD14 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PSMD14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PSMD14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PSMD14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PSMD14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PSMD14 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSMD14 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PSMD14 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PSMD14 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.