{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into glioma pathogenesis have revealed that the long noncoding RNA PSMD6‐AS1—also referenced as lnc00462717—is markedly down-regulated in glioma tissues compared to adjacent normal brain tissues, suggesting its potential role as a tumor suppressor. This reduced expression correlates with aggressive disease characteristics, highlighting the importance of PSMD6‐AS1 in glioma biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn vitro experiments further demonstrate that overexpression of PSMD6‐AS1 inhibits key malignant features of glioma cells, including proliferation, survival, and migration. Conversely, knockdown of PSMD6‐AS1 enhances these tumorigenic properties, indicating that its normal function is crucial for restraining glioma progression. Mechanistic studies identified that PSMD6‐AS1, by directly targeting the oncogene MDM2, modulates the MDM2/MAPK signaling pathway—a critical pathway involved in cell growth and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nThese findings suggest that PSMD6‐AS1 not only serves as a vital regulator of glioma cell behavior via the MDM2/MAPK axis but also holds promise as a novel biomarker and potential therapeutic target. Further exploration of PSMD6‐AS1 could drive the development of new strategies to manage and treat glioma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aiqin Wang, Mingzhu Meng, Xiuhe Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ENST00462717 suppresses the proliferation, survival, and migration by inhibiting MDM2/MAPK pathway in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.02.015"}], "href": "https://doi.org/10.1016/j.bbrc.2017.02.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28189682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28189682"}]}]}]}