{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPSMG3‐AS1 is an oncogenic long non‐coding RNA that has been implicated in the pathogenesis of multiple cancer types. In breast cancer, PSMG3‐AS1 is upregulated and functions as a competing endogenous RNA that sponges miR‐143‐3p, thereby modulating the expression of key proteins such as COL1A1 and PCNA to promote cell proliferation and migration. Moreover, its expression pattern in breast cancer has spurred investigations into its role in other malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, overexpression of PSMG3‐AS1 in plasma distinguishes patients from those with sarcoidosis and healthy controls; mechanistically, it facilitates tumor cell proliferation by inducing methylation of the miR‐34a gene and reducing miR‐34a levels. In non‐small cell lung cancer, PSMG3‐AS1 is similarly upregulated, where it impairs the function of miR‐613 and leads to an increase in SphK1 expression, thereby enhancing cell proliferation. Further, in endometrial carcinoma, an inverse regulation between PSMG3‐AS1 and the tumor suppressor lncRNA MEG3 has been observed, with each inhibiting the other’s expression and consequently affecting cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional evidence in gastric and prostate cancers underscores the multifaceted oncogenic role of PSMG3‐AS1. In gastric cancer, elevated levels of this lncRNA correlate with increased tumor proliferative and invasive capabilities, potentially through disruption of the CAV1/miR‐451a signaling pathway. In prostate carcinoma, PSMG3‐AS1 overexpression is associated with enhanced methylation of the miR‐106b gene, leading to its downregulation and a consequent relief of the miR‐106b–mediated inhibition on cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Cui, Yuhua Fan, Guangcai Zhao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-449b-5p targets lncRNA PSMG3-AS1 to suppress cancer cell proliferation in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-020-01189-5"}], "href": "https://doi.org/10.1186/s12890-020-01189-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32471413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32471413"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liusheng Chen, Guanliang Wang, Zihui Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LncRNA PSMG3-AS1 Distinguishes Glioblastomas from Sarcoidosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-020-01605-9"}], "href": "https://doi.org/10.1007/s12031-020-01605-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32529538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32529538"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weiyu Shen, Xunyu Hong, Chenghua Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1900499"}], "href": "https://doi.org/10.1080/15384101.2021.1900499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33849377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33849377"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shuai Huang, Jiankun Chen, Xuexiao Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs PSMG3-AS1 and MEG3 negatively regulate each other to participate in endometrial carcinoma cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-021-09931-y"}], "href": "https://doi.org/10.1007/s00335-021-09931-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34751795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34751795"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yi Wang, Zhongshi Hong, Shenghong Wei, et al. 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