PSTPIP1 Gene

Name	proline-serine-threonine phosphatase interacting protein 1
Description	This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPSTPIP1 is a multifunctional, cytoskeleton‐associated adaptor protein predominantly expressed in hematopoietic and myeloid cells that orchestrates key inflammatory signaling pathways. It directly binds to pyrin and modulates IL‑1β processing, NF‑κB activation, and apoptosis by facilitating the assembly of the ASC pyroptosome and the subsequent activation of caspase‑1. These interactions are crucial for proper innate immune responses and, when dysregulated, can lead to exaggerated inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n \nIn addition to its role in inflammasome regulation, PSTPIP1 is integral to cytoskeletal remodeling and immune cell activation. It couples membrane receptors such as CD2 with the actin polymerization machinery—including interactions with proteins like WASp—to coordinate the formation of the immunological synapse in T cells. Moreover, PSTPIP1 regulates cellular motility by modulating endocytosis and balancing podosome versus filopodia formation in macrophages."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": "\n \nImportantly, pathogenic mutations in PSTPIP1 underlie a spectrum of autoinflammatory disorders—including PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) and PAMI syndromes—by altering its phosphorylation state and binding affinity for pyrin. Such mutations enhance pyrin-mediated inflammasome activation and the release of proinflammatory cytokines (e.g. IL‑1β and IL‑18), resulting in clinical manifestations that may also overlap with conditions such as rheumatoid arthritis and neutropenia. These findings underscore that perturbations in normal PSTPIP1 function, whether by altering cytoskeletal dynamics or misregulating immune signals, are central to the pathogenesis of these autoinflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carol A Wise, Joseph D Gillum, Christine E Seidman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/11.8.961"}], "href": "https://doi.org/10.1093/hmg/11.8.961"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11971877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11971877"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nitza G Shoham, Michael Centola, Elizabeth Mansfield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2135380100"}], "href": "https://doi.org/10.1073/pnas.2135380100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14595024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14595024"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Je-Wook Yu, Teresa Fernandes-Alnemri, Pinaki Datta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.08.029"}], "href": "https://doi.org/10.1016/j.molcel.2007.08.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17964261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17964261"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrea L Waite, Philip Schaner, Neil Richards, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyrin Modulates the Intracellular Distribution of PSTPIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0006147"}], "href": "https://doi.org/10.1371/journal.pone.0006147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19584923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19584923"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yeliz Z Akkaya-Ulum, Banu Balci-Peynircioglu, Nuhan Purali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyrin-PSTPIP1 colocalises at the leading edge during cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.10514"}], "href": "https://doi.org/10.1002/cbin.10514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26179737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26179737"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Karen Badour, Jinyi Zhang, Fabio Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1074-7613(02)00516-2"}], "href": "https://doi.org/10.1016/s1074-7613(02"}, {"type": "t", "text": "00516-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12530983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12530983"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wiebke Baum, Vladimir Kirkin, Sara B Mateus Fernández, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M502222200"}], "href": "https://doi.org/10.1074/jbc.M502222200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16204241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16204241"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hailin Yang, Ellis L Reinherz "}, {"type": "b", "children": [{"type": "t", "text": "CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.176.10.5898"}], "href": "https://doi.org/10.4049/jimmunol.176.10.5898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16670297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16670297"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kate M Cooper, David A Bennin, Anna Huttenlocher "}, {"type": "b", "children": [{"type": "t", "text": "The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e08-02-0225"}], "href": "https://doi.org/10.1091/mbc.e08-02-0225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18480402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18480402"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Taylor W Starnes, David A Bennin, Xinyu Bing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-07-516948"}], "href": "https://doi.org/10.1182/blood-2013-07-516948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24421327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24421327"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tamara Marcos, Virginia Ruiz-Martín, María Luisa de la Puerta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.12912"}], "href": "https://doi.org/10.1111/febs.12912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25040622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25040622"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Willemijn J M Janssen, Valeria Grobarova, Jardin Leleux, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Dermatol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2230.2011.04137.x"}], "href": "https://doi.org/10.1111/j.1365-2230.2011.04137.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21790734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21790734"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Basil M Fathalla, Adel M Al-Wahadneh, Mariam Al-Mutawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel de novo PSTPIP1 mutation in a boy with pyogenic arthritis, pyoderma gangrenosum, acne (PAPA) syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Rheumatol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24960411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24960411"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bhattaram Siddhartha Kumar, Pasupuleti Santhosh Kumar, Nannepaga Sowgandhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel mutations in CD2BP1 gene in clinically proven rheumatoid arthritis patients of south India."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2016.05.009"}], "href": "https://doi.org/10.1016/j.ejmg.2016.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27184502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27184502"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yangjing Chen, Ruimin Zhao, Qian Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of HPIP Inhibits the Proliferation and Invasion of Head-and-Neck Squamous Cell Carcinoma Cells by Regulating PI3K/Akt Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14612603423476"}], "href": "https://doi.org/10.3727/096504016X14612603423476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27458096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27458096"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Guilaine Boursier, Maryam Piram, Cécile Rittore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic Associations of PSTPIP1 Sequence Variants in PSTPIP1-Associated Autoinflammatory Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2020.08.028"}], "href": "https://doi.org/10.1016/j.jid.2020.08.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33218716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33218716"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Deborah L Stone, Amanda Ombrello, Juan I Arostegui, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Rare missense variants in the SH3 domain of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PSTPIP1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " are associated with hidradenitis suppurativa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "HGG Adv (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.xhgg.2023.100187"}], "href": "https://doi.org/10.1016/j.xhgg.2023.100187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37013170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37013170"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Manel Mejbri, Raffaele Renella, Fabio Candotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory (PAMI) Syndrome: A Systematic Review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes14081655"}], "href": "https://doi.org/10.3390/genes14081655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37628706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37628706"}]}]}]}
Synonyms	CD2BP1L, CD2BP1S, PSTPIP, CD2BP1, PAPAS, H-PIP
Proteins	PPIP1_HUMAN
NCBI Gene ID	9051
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PSTPIP1 has 4,417 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for PSTPIP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PSTPIP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSTPIP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSTPIP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PSTPIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PSTPIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSTPIP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PSTPIP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSTPIP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSTPIP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSTPIP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PSTPIP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PSTPIP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSTPIP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PSTPIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PSTPIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PSTPIP1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PSTPIP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PSTPIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PSTPIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PSTPIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PSTPIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PSTPIP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PSTPIP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PSTPIP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate PSTPIP1 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PSTPIP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PSTPIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PSTPIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PSTPIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PSTPIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PSTPIP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSTPIP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PSTPIP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PSTPIP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PSTPIP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PSTPIP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PSTPIP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PSTPIP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PSTPIP1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PSTPIP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PSTPIP1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.