{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNA PTCSC1 has been identified as an oncogenic factor in esophageal squamous cell carcinoma (ESCC). Elevated in ESCC tissues and cell lines compared with normal counterparts, PTCSC1 promotes both proliferation and migration of ESCC cells in vitro and accelerates tumor growth in vivo. Mechanistic studies indicate that PTCSC1 exerts its tumor-promoting effects by activating the Akt signaling pathway. Notably, inhibition of Akt signaling with MK-2206 was found to abolish the enhanced pro-proliferative and pro-migratory capabilities induced by PTCSC1. These findings suggest that targeting PTCSC1 could represent a novel therapeutic strategy to combat ESCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Liu, Xiangsen Liang, Shengzhuang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA PTCSC1 drives esophageal squamous cell carcinoma progression through activating Akt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2020.104543"}], "href": "https://doi.org/10.1016/j.yexmp.2020.104543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32971114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32971114"}]}]}]}