{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPapillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a long intergenic noncoding RNA originally identified as being strictly thyroid‐specific and significantly downregulated in papillary thyroid carcinoma (PTC). Its expression is tightly linked to a risk allele (rs944289) that disrupts binding sites for transcriptional activators, and restoration of PTCSC3 in PTC cell lines suppresses cell growth while altering genes involved in DNA replication, repair, recombination, cell movement, and cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther evidence points to a critical tumor‐suppressive role for PTCSC3 in PTC where it regulates metastasis and proliferation by sponging miR‑574‑5p. Overexpression of PTCSC3 not only increases the expression of the suppressor of cancer cell invasion (SCAI) but also attenuates β‑catenin signaling, thereby reducing cell migration and proliferation in both in vitro studies and in vivo tumor models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations have suggested that PTCSC3 may target oncogenic factors such as S100A4, further corroborating its suppressive function in thyroid carcinogenesis. In this context, PTCSC3 has also been examined for its involvement in drug resistance mechanisms in anaplastic thyroid cancer, reinforcing its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond thyroid malignancies, emerging studies have expanded the role of PTCSC3 to other cancers. In triple‐negative breast cancer, PTCSC3 overexpression inhibits cell proliferation by downregulating the oncogenic lncRNA H19, while in gastric cancer, reduced plasma levels of PTCSC3 are associated with early disease and poorer overall survival; restoration of its expression curtails cell growth. Moreover, preliminary evidence in glioma suggests that PTCSC3’s tumor suppressor function may extend to diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jaroslaw Jendrzejewski, Huiling He, Hanna S Radomska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1205654109"}], "href": "https://doi.org/10.1073/pnas.1205654109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22586128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22586128"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoming Wang, Xiubo Lu, Zushi Geng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PTCSC3/miR-574-5p Governs Cell Proliferation and Migration of Papillary Thyroid Carcinoma via Wnt/β-Catenin Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26142"}], "href": "https://doi.org/10.1002/jcb.26142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28513866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28513866"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jaroslaw Jendrzejewski, Andrew Thomas, Sandya Liyanarachchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2015-2247"}], "href": "https://doi.org/10.1210/jc.2015-2247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26274343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26274343"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiao-Ming Wang, Yang Liu, Yu-Xia Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through STAT3/INO80 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2018.1449610"}], "href": "https://doi.org/10.1080/15384047.2018.1449610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29561707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29561707"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ning Wang, Mingsheng Hou, Ying Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28769"}], "href": "https://doi.org/10.1002/jcb.28769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31026090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31026090"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guodong Zhang, Nannan Chi, Qingfeng Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PTCSC3 Is a Biomarker for the Treatment and Prognosis of Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biother Radiopharm (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cbr.2019.2991"}], "href": "https://doi.org/10.1089/cbr.2019.2991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31702383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31702383"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shujun Xia, Ri Ji, Weiwei Zhan "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12883-017-0813-6"}], "href": "https://doi.org/10.1186/s12883-017-0813-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28187755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28187755"}]}]}]}