{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstracts focus on the regulatory roles of certain noncoding RNAs—such as the circular RNA MFACR and microRNA‐652—in cardiac physiology, cancer progression, and atherosclerosis. For example, one study (PMID 28498369) demonstrates that MFACR regulates mitochondrial fission and apoptosis in the heart by sequestering miR‑652‑3p, thereby modulating downstream targets that are critical for cardiomyocyte survival. Likewise, another study (PMID 25145628) shows that inhibiting miR‑652 improves cardiac function in a model of pressure overload by affecting pathways linked to hypertrophy and apoptosis. Additionally, a separate investigation (PMID 30093563) indicates that miR‑652 functions as an oncogenic factor in endometrial cancer by promoting proliferation, migration, and metastasis through the repression of tumor suppressor genes. Finally, a brief mention in another work (PMID 30674440) underscores the role of microRNAs in endothelial cell dysfunction associated with atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, none of these abstracts mention or characterize PTGES2‑AS1. Therefore, based on the provided literature, there is no available information to summarize a function for PTGES2‑AS1. Further investigation or additional sources would be necessary to determine the role of PTGES2‑AS1 in these or other biological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kun Wang, Tian-Yi Gan, Na Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2017.61"}], "href": "https://doi.org/10.1038/cdd.2017.61"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28498369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28498369"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bianca C Bernardo, Sally S Nguyen, Catherine E Winbanks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.14-253856"}], "href": "https://doi.org/10.1096/fj.14-253856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25145628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25145628"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaomei Sun, Samina Dongol, Chunping Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-652 Promotes Tumor Proliferation and Metastasis by Targeting "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RORA"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-18-0267"}], "href": "https://doi.org/10.1158/1541-7786.MCR-18-0267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30093563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30093563"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rongzhong Huang, Zicheng Hu, Yu Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.01.032"}], "href": "https://doi.org/10.1016/j.ebiom.2019.01.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30674440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30674440"}]}]}]}