Name | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
Description | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPTGS2 (cyclooxygenase‑2) plays a central role in maintaining tissue homeostasis and regulating local inflammatory responses. In normal and injured tissues, PTGS2‐derived prostaglandin E2 (PGE₂) helps preserve fibroblast quiescence and contributes to mucosal repair. For example, increasing tissue stiffness in fibrotic lung injury suppresses PTGS2 expression and PGE₂ synthesis, thereby unleashing fibroblast activation and promoting fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, PTGS2‐derived PGE₂ has been shown to mediate mucosal healing following colonic injury"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and experimental models link environmental pollutants to neuroinflammation accompanied by altered PTGS2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in hematopoietic cells, inducible PTGS2 expression is observed during megakaryocytopoiesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and PTGS2‐dependent prostanoid synthesis in lung fibroblasts exposed to cigarette smoke further underscores its role in creating a proinflammatory milieu."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in tissue repair, PTGS2 is intricately involved in modulating immune responses. Through its product PGE₂, PTGS2 establishes feedback loops that redirect the differentiation of dendritic cells towards immunosuppressive myeloid-derived suppressor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, studies investigating functional variants and downstream synthases have provided insights into how PTGS2 activity is finely tuned under both physiologic and pathologic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant PTGS2 expression is a common feature of many malignancies where it promotes tumorigenesis through multiple mechanisms. Elevated PTGS2 levels are linked to enhanced angiogenesis, increased cell proliferation, invasion, and metastasis in cancers including breast, colon, lung, ovarian, and cholangiocarcinoma. For instance, in breast cancer PTGS2 is upregulated via oncogenic HER‑2 signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", whereas in lung and other cancers, PTGS2-driven PGE₂ production facilitates tumor cell dissemination and matrix remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": " Additional studies have demonstrated that endoplasmic reticulum stress and viral oncogenes (e.g., from hepatitis B) can induce PTGS2 expression to promote invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", and genetic polymorphisms or microRNA‐mediated regulation of PTGS2 further impact cancer risk and progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "20"}]}, {"type": "t", "text": " In ovarian"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ", lung adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ", cholangiocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": ", and colorectal cancers"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "27"}]}, {"type": "t", "text": "its overexpression is associated with aggressive phenotypes.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPTGS2 expression and activity are regulated at multiple levels. Hypoxic conditions, endoplasmic reticulum stress, and viral infections trigger transcriptional activation of PTGS2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": " Furthermore, posttranscriptional regulation by RNA-binding proteins such as HuR—whose translocation and phosphorylation (mediated by kinases including PKCδ) enhance PTGS2 mRNA stability—coupled with microRNA interactions (for example, by miR‑16) constitute additional layers of control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "36"}]}, {"type": "t", "text": " These regulatory mechanisms underscore the context‐dependent expression of PTGS2, as highlighted by comparative analyses of its distribution in normal versus diseased tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGiven its prominent role in orchestrating inflammatory, proliferative, and immunomodulatory pathways, PTGS2 constitutes an attractive therapeutic target. Its inhibition using selective drugs has been shown to reduce tumor invasiveness and improve outcomes in ischemic and inflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "38", "end_ref": "40"}]}, {"type": "t", "text": " Recently, novel agents such as cannabidiol have been reported to trigger proapoptotic pathways in cancer cells via initial upregulation of PTGS2 and its downstream targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "41"}]}, {"type": "t", "text": " In parallel, emerging evidence regarding epigenetic modifications such as gene promoter methylation suggests additional strategies for modulating PTGS2 expression in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "42"}]}, {"type": "t", "text": " Collectively, these findings affirm the multifaceted functions of PTGS2 and aide in guiding the development of targeted therapies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fei Liu, Justin D Mih, Barry S Shea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201004082"}], "href": "https://doi.org/10.1083/jcb.201004082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20733059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20733059"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Masayuki Fukata, Anli Chen, Arielle Klepper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2006.06.017"}], "href": "https://doi.org/10.1053/j.gastro.2006.06.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16952555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16952555"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Esperanza Ontiveros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Cogn (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bandc.2008.04.008"}], "href": "https://doi.org/10.1016/j.bandc.2008.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18550243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18550243"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bianca Rocca, Paola Secchiero, Giovanni Ciabattoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.112202999"}], "href": "https://doi.org/10.1073/pnas.112202999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12032335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12032335"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christine A Martey, Stephen J Pollock, Chantal K Turner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00239.2003"}], "href": "https://doi.org/10.1152/ajplung.00239.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15234907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15234907"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Natasa Obermajer, Ravikumar Muthuswamy, Jamie Lesnock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-07-365825"}], "href": "https://doi.org/10.1182/blood-2011-07-365825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21972293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21972293"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anastasia Papafili, Michael R Hill, David J Brull, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.atv.0000030340.80207.c5"}], "href": "https://doi.org/10.1161/01.atv.0000030340.80207.c5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12377741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12377741"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Makoto Murakami, Karin Nakashima, Daisuke Kamei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305108200"}], "href": "https://doi.org/10.1074/jbc.M305108200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12835322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12835322"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kotha Subbaramaiah, Larry Norton, William Gerald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111415200"}], "href": "https://doi.org/10.1074/jbc.M111415200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11901151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11901151"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gaorav P Gupta, Don X Nguyen, Anne C Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mediators of vascular remodelling co-opted for sequential steps in lung metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05760"}], "href": "https://doi.org/10.1038/nature05760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17429393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17429393"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jeng-Wei Tjiu, Jau-Shiuh Chen, Chia-Tung Shun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.310"}], "href": "https://doi.org/10.1038/jid.2008.310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18843292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18843292"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shinsuke Kiritoshi, Takeshi Nishikawa, Kazuhiro Sonoda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.52.10.2570"}], "href": "https://doi.org/10.2337/diabetes.52.10.2570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14514642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14514642"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Francesco Cipollone, Elena Toniato, Stefano Martinotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jama.291.18.2221"}], "href": "https://doi.org/10.1001/jama.291.18.2221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15138244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15138244"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jui-Hsiang Hung, Ih-Jen Su, Huan-Yao Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403568200"}], "href": "https://doi.org/10.1074/jbc.M403568200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15319438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15319438"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Takashi Kuwano, Shintaro Nakao, Hidetaka Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0473com"}], "href": "https://doi.org/10.1096/fj.03-0473com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14769824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14769824"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Enrique Lara-Pezzi, Maria Victoria Gómez-Gaviro, Beatriz G Gálvez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15887"}], "href": "https://doi.org/10.1172/JCI15887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12488433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12488433"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xuemei Zhang, Xiaoping Miao, Wen Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gastro.2005.05.003"}], "href": "https://doi.org/10.1016/j.gastro.2005.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16083713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16083713"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Antonio Strillacci, Cristiana Griffoni, Pasquale Sansone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2008.12.010"}], "href": "https://doi.org/10.1016/j.yexcr.2008.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19133256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19133256"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Carsten Denkert, Klaus-Jürgen Winzer, Berit-Maria Müller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.11437"}], "href": "https://doi.org/10.1002/cncr.11437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12784332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12784332"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Daniele Campa, Shanbeh Zienolddiny, Valentina Maggini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgh008"}], "href": "https://doi.org/10.1093/carcin/bgh008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14604894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14604894"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Carsten Denkert, Martin Köbel, Sören Pest, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)64912-7"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "64912-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11891188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11891188"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jen-Liang Su, Jin-Yuan Shih, Men-Luh Yen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.can-03-1301"}], "href": "https://doi.org/10.1158/0008-5472.can-03-1301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14744769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14744769"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Rafael Rosell, Giorgio Scagliotti, Kathleen D Danenberg, et al. 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Synonyms | PGHS-2, PHS-2, GRIPGHS, COX-2, HCOX-2 |
Proteins | PGH2_HUMAN |
NCBI Gene ID | 5743 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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PTGS2 has 23,722 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.
Click the + buttons to view associations for PTGS2 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by PTGS2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PTGS2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PTGS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PTGS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PTGS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PTGS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of PTGS2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PTGS2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PTGS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PTGS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PTGS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Gene Mutation Profiles | cell lines with PTGS2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with PTGS2 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with PTGS2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTGS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of PTGS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PTGS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PTGS2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PTGS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing PTGS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PTGS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PTGS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing PTGS2 protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PTGS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with PTGS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with PTGS2 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with PTGS2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by PTGS2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with PTGS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PTGS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PTGS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PTGS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with PTGS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with PTGS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
DrugBank Drug Targets | interacting drugs for PTGS2 protein from the curated DrugBank Drug Targets dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PTGS2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTGS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of PTGS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PTGS2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with PTGS2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with PTGS2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of PTGS2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with PTGS2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PTGS2 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PTGS2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PTGS2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PTGS2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PTGS2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PTGS2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding PTGS2 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving PTGS2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving PTGS2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving PTGS2 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing PTGS2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing PTGS2 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing PTGS2 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by PTGS2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by PTGS2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by PTGS2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PTGS2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PTGS2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PTGS2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding PTGS2 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
GWASdb SNP-Disease Associations | diseases associated with PTGS2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with PTGS2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PTGS2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for PTGS2 protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of PTGS2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of PTGS2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of PTGS2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PTGS2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for PTGS2 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with PTGS2 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PTGS2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
HumanCyc Pathways | pathways involving PTGS2 protein from the HumanCyc Pathways dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for PTGS2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PTGS2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate PTGS2 protein from the curated KEA Substrates of Kinases dataset. | |
KEGG Pathways | pathways involving PTGS2 protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PTGS2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PTGS2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PTGS2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PTGS2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PTGS2 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PTGS2 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing PTGS2 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PTGS2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by PTGS2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting PTGS2 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PTGS2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of PTGS2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by PTGS2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of PTGS2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
MW Enzyme Metabolite Associations | interacting metabolites for PTGS2 protein from the MW Gene Metabolite Associations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of PTGS2 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
PANTHER Pathways | pathways involving PTGS2 protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for PTGS2 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PTGS2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of PTGS2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving PTGS2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving PTGS2 protein from the Wikipathways PFOCR 2024 dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate PTGS2 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
PID Pathways | pathways involving PTGS2 protein from the PID Pathways dataset. | |
Reactome Pathways 2014 | pathways involving PTGS2 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving PTGS2 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PTGS2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PTGS2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PTGS2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PTGS2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with PTGS2 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of PTGS2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PTGS2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PTGS2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PTGS2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PTGS2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PTGS2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PTGS2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PTGS2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PTGS2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PTGS2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving PTGS2 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving PTGS2 protein from the WikiPathways Pathways 2024 dataset. | |