{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLncRNA PTPRG‐AS1 is emerging as a critical oncogenic regulator in various cancers. In epithelial ovarian cancer, for instance, its overexpression correlates with advanced stage, high grade, metastasis, and poor patient survival, suggesting its promise as a prognostic biomarker. In addition, despite documented oncogenic properties in diverse neoplasms, its specific role in modulating radiosensitivity—for example, in nonsmall cell lung cancer—remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies have revealed that PTPRG‐AS1 functions as a competing endogenous RNA. In lung adenocarcinoma, for example, PTPRG‐AS1 sponges miR‑124‑3p to upregulate cyclin D1 (CCND1), thereby driving cell cycle progression and proliferation. Similarly, in nasopharyngeal carcinoma, PTPRG‐AS1 modulates radiosensitivity by sequestering miR‑124‑3p to elevate LHX2 expression, which then activates the Notch pathway to attenuate the response to radiotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, PTPRG‐AS1 contributes to tumor progression through additional molecular mechanisms. In triple‐negative breast cancer, transcriptional activation by POU2F2 elevates PTPRG‐AS1 levels, which in turn sponges miR‑376c‑3p to upregulate SLC7A11, thereby modulating ferroptosis and promoting proliferation. In another mechanism operative in nasopharyngeal carcinoma, upregulation of PTPRG‐AS1 by HOXA10 enhances its binding to RNA‐binding protein HuR, leading to stabilization of USP1 mRNA and stimulation of cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xue-Ying Ren, Wei-Bin Yang, Yun Tian "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of long noncoding RNA PTPRG-AS1 is associated with poor prognosis in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rev Assoc Med Bras (1992) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1806-9282.66.7.948"}], "href": "https://doi.org/10.1590/1806-9282.66.7.948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32844927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32844927"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qiang Ma, Rungui Niu, Wei Huang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "POU2F2-mediated upregulation of lncRNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PTPRG-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenomics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/epi-2023-0100"}], "href": "https://doi.org/10.2217/epi-2023-0100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38318853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38318853"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "He Zhou, Chang Deng, Yue Xi "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of HOXA10 in nasopharyngeal carcinoma cell proliferation through the PTPRG-AS1/USP1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.70025"}], "href": "https://doi.org/10.1002/jbt.70025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39445487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39445487"}]}]}]}