{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requested a summary of PUM3 function, none of the 28 provided abstracts mention PUM3. Instead, they present an extensive body of work on lysine‐specific demethylase 1 (LSD1, also known as KDM1A), a key epigenetic regulator. For example, one study showed that LSD1 is recruited by the androgen receptor to remove repressive H3K9 methylation marks and thereby enable hormonally driven gene activation critical for prostate physiology and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, a genome‐wide association study in celiac disease patients identified a risk locus unrelated to LSD1, underscoring that not all studies in the collection address histone demethylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA number of reports in this set elaborate on LSD1’s role during development and the dynamic regulation of cell‐fate decisions. LSD1 is shown to “decommission” active enhancers during embryonic stem cell differentiation and is required for proper pituitary organogenesis, acting within both coactivator and corepressor complexes to fine‐tune gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies extend LSD1’s developmental importance to hematopoiesis, gametogenesis, and neural lineage specification. LSD1 partners with transcriptional repressors such as GFI1 and GFI1B during the endothelial‐to‐hematopoietic transition, modulates the epigenetic landscape in developing sperm to influence transgenerational inheritance, and functions downstream of microRNAs (for instance, miR‑137) to control neural stem cell proliferation and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLSD1 also exerts important regulatory functions in metabolic contexts. It modulates the transcription of energy‐expenditure genes in adipocytes and is critical for adipogenesis via the fine balance of H3K4/H3K9 histone marks; these actions ensure that differentiation programs, such as the induction of C/EBPα in white adipocytes, proceed appropriately."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of LSD1 is further implicated in various cancers and reprogramming phenomena. In glioblastoma, for example, LSD1 stabilization via phosphorylation events supports an undifferentiated, stem‐like state and tumor propagation. Similarly, in MLL‐rearranged leukemias and medulloblastoma, pharmacological inhibition of LSD1 promotes differentiation and suppresses leukemic/oncogenic potential. Aberrant LSD1 expression is also noted in gastric cancer, where it helps sculpt the tumor immune microenvironment, and its activity is linked to viral chromatin regulation in herpes simplex virus infection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of liver and systemic regulation, one study highlighted how p53 recruits LSD1 to repress alpha‐fetoprotein transcription during liver development and regeneration, emphasizing its role in balancing gene activation and repression during tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work has focused on brown adipose tissue where LSD1 modulates thermogenic gene programs. Through interactions with factors such as FGF19 and Nrf1, LSD1 is central to maintaining the chromatin landscape required for energy homeostasis; its loss shifts BAT toward a WAT‑like phenotype with diminished thermogenic capacity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, a series of studies reveal LSD1’s critical functions in neuronal biology and plasticity. Its interplay with chromatin and transcriptional regulators is essential for proper neural differentiation, synaptic activity, and cognitive function—and dysregulation of LSD1 is linked to neuropsychiatric disorders, exhaustion of CD8+ T cells, and even defects in myogenic differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while none of the abstracts address PUM3, they collectively underscore the multifaceted, context‐dependent roles of LSD1 in modulating chromatin structure and gene expression. Through its demethylase activity, LSD1 orchestrates diverse biological processes ranging from hormone‐responsive transcription and stem cell fate decisions to metabolism, oncogenesis, and neural function. Further investigation is necessary to clarify the role (if any) of PUM3 in these or other epigenetic pathways.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eric Metzger, Melanie Wissmann, Na Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04020"}], "href": "https://doi.org/10.1038/nature04020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16079795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16079795"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing Wang, Sarah Hevi, Julia K Kurash, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.268"}], "href": "https://doi.org/10.1038/ng.268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19098913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19098913"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David A van Heel, Lude Franke, Karen A Hunt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng2058"}], "href": "https://doi.org/10.1038/ng2058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17558408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17558408"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Warren A Whyte, Steve Bilodeau, David A Orlando, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancer decommissioning by LSD1 during embryonic stem cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10805"}], "href": "https://doi.org/10.1038/nature10805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22297846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22297846"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jianxun Wang, Kathleen Scully, Xiaoyan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Opposing LSD1 complexes function in developmental gene activation and repression programmes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05671"}], "href": "https://doi.org/10.1038/nature05671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17392792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17392792"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "William J Harris, Xu Huang, James T Lynch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2012.03.014"}], "href": "https://doi.org/10.1016/j.ccr.2012.03.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22464800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22464800"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shireen Saleque, Jonghwan Kim, Heather M Rooke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.06.039"}], "href": "https://doi.org/10.1016/j.molcel.2007.06.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17707228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17707228"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Keith Siklenka, Serap Erkek, Maren Godmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of histone methylation in developing sperm impairs offspring health transgenerationally."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aab2006"}], "href": "https://doi.org/10.1126/science.aab2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26449473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26449473"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "GuoQiang Sun, Peng Ye, Kiyohito Murai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1532"}], "href": "https://doi.org/10.1038/ncomms1532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22068596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22068596"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Todd S Macfarlan, Wesley D Gifford, Saurabh Agarwal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2008511"}], "href": "https://doi.org/10.1101/gad.2008511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21357675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21357675"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Roshana Thambyrajah, Milena Mazan, Rahima Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3276"}], "href": "https://doi.org/10.1038/ncb3276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26619147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26619147"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shinjiro Hino, Akihisa Sakamoto, Katsuya Nagaoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1755"}], "href": "https://doi.org/10.1038/ncomms1755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22453831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22453831"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Charles T Foster, Oliver M Dovey, Larissa Lezina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00521-10"}], "href": "https://doi.org/10.1128/MCB.00521-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20713442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20713442"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Melina M Musri, Mari Carmen Carmona, Felicia A Hanzu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone demethylase LSD1 regulates adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.151209"}], "href": "https://doi.org/10.1074/jbc.M110.151209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20656681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20656681"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Aidong Zhou, Kangyu Lin, Sicong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3396"}], "href": "https://doi.org/10.1038/ncb3396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27501329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27501329"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Bruno Di Stefano, Samuel Collombet, Janus Schou Jakobsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3326"}], "href": "https://doi.org/10.1038/ncb3326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26974661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26974661"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-022-01557-1"}], "href": "https://doi.org/10.1186/s12943-022-01557-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35296335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35296335"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Monica Cusan, Sheng F Cai, Helai P Mohammad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2017-09-807024"}], "href": "https://doi.org/10.1182/blood-2017-09-807024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29453291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29453291"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Patricio Fuentes, José Cánovas, F Andrés Berndt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CoREST/LSD1 control the development of pyramidal cortical neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cereb Cortex (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cercor/bhr218"}], "href": "https://doi.org/10.1093/cercor/bhr218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21878487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21878487"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wen-Wei Tsai, Thi T Nguyen, Yang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00287-08"}], "href": "https://doi.org/10.1128/MCB.00287-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18573881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18573881"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Delphine Duteil, Milica Tosic, Franziska Lausecker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.09.053"}], "href": "https://doi.org/10.1016/j.celrep.2016.09.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27760309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27760309"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Sangwon Byun, Young-Chae Kim, Yang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201695500"}], "href": "https://doi.org/10.15252/embj.201695500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28446510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28446510"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Katerina Hatzi, Huimin Geng, Ashley S Doane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41590-018-0273-1"}], "href": "https://doi.org/10.1038/s41590-018-0273-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30538335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30538335"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xing Zeng, Mark P Jedrychowski, Yi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.285312.116"}], "href": "https://doi.org/10.1101/gad.285312.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27566776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27566776"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jun Mukai, Enrico Cannavò, Gregg W Crabtree, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2019.09.014"}], "href": "https://doi.org/10.1016/j.neuron.2019.09.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31606247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31606247"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Francesco Rusconi, Barbara Grillo, Luisa Ponzoni, et al. 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