PWRN1 Gene

HGNC Family Non-coding RNAs
Name Prader-Willi region non-protein coding RNA 1
Description This gene is located in the Prader-Willi syndrome (PWS) region of chromosome 15, which is known to undergo imprinting. The transcript is believed to be non-coding. It is bi-allelically expressed in testis and kidney, but mono-allelically expressed from the paternal allele in brain. This gene is poly-adenylated and is known to undergo alternative splicing. Transcript variants may represent part of a complex imprinting center-SNURF-SNRPN transcription unit. The contribution of this gene to the PWS phenotype is unknown, but it has been suggested that it may play a role in establishing paternal imprinting in the PWS region, perhaps by maintaining the paternal allele in an open chromatin configuration. [provided by RefSeq, Sep 2009]
Summary
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Microarray analyses of human bone marrow mesenchymal stem cells revealed that PWRN1-209 is upregulated on microstructured titanium surfaces, where it promotes osteogenic differentiation via modulation of integrin-FAK-ALP signaling pathways, thereby facilitating osseointegration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations in skeletal malignancies, such as osteosarcoma, have examined the expression patterns and clinical relevance of PWRN1, suggesting that its altered regulation may serve as a potential biomarker or therapeutic target in bone cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of hepatocellular carcinoma, PWRN1 acts as a tumor suppressor. Down-regulated in HCC, its re-expression inhibits tumor cell proliferation by binding to pyruvate kinase M2 (PKM2) and maintaining its high activity state, which prevents the formation of low-activity PKM2 dimers. This mechanism reduces PKM2 nuclear translocation, dampens c-Myc-mediated LDHA expression, and decreases aerobic glycolysis, collectively impeding cancer cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karin Buiting, Hülya Nazlican, Danuta Galetzka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2006.12.008"}], "href": "https://doi.org/10.1016/j.ygeno.2006.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17337158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17337158"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingyue Wang, Xiyuan Ge, Yan Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray analysis reveals that lncRNA PWRN1-209 promotes human bone marrow mesenchymal stem cell osteogenic differentiation on microtopography titanium surface in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Mater Res B Appl Biomater (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbm.b.34620"}], "href": "https://doi.org/10.1002/jbm.b.34620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32447825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32447825"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiyuan Shi, Qiang Fu, Pei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA PWRN1 is lowly expressed in osteosarcoma and modulates cancer proliferation and migration by targeting hsa-miR-214-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2370"}], "href": "https://doi.org/10.1002/iub.2370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32870579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32870579"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mingming Fei, Xianying Li, Shuhang Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PWRN1 inhibits the progression of hepatocellular carcinoma by activating PKM2 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2024.216620"}], "href": "https://doi.org/10.1016/j.canlet.2024.216620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38218456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38218456"}]}]}]}
Synonyms NCRNA00198
NCBI Gene ID 791114
API
Download Associations
Predicted Functions View PWRN1's ARCHS4 Predicted Functions.
Co-expressed Genes View PWRN1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PWRN1's ARCHS4 Predicted Functions.

Functional Associations

PWRN1 has 657 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.

Click the + buttons to view associations for PWRN1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PWRN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of PWRN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with PWRN1 gene from the CellMarker Gene-Cell Type Associations dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of PWRN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PWRN1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PWRN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PWRN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with PWRN1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of PWRN1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PWRN1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PWRN1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of PWRN1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of PWRN1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of PWRN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PWRN1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with PWRN1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with PWRN1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with PWRN1 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with PWRN1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PWRN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PWRN1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PWRN1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PWRN1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.