RAB1B Gene

HGNC Family	Ras small GTPases superfamily
Name	RAB1B, member RAS oncogene family
Description	Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab1B is emerging as a central regulator of intracellular vesicular trafficking, orchestrating early secretory events between the endoplasmic reticulum and Golgi membranes. Studies have demonstrated that Rab1B modulates the recruitment of coat complexes—such as COPI at the ER–Golgi interface by interacting with factors like GBF1 and stabilizing Arf1—as well as ensuring proper delivery of cargo, including viral glycoproteins, during particle assembly. Furthermore, Rab1B association with ATG9A‐containing vesicles marks its importance in controlling autophagosome formation and overall cargo sorting at ER exit sites."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel to its core role in vesicle trafficking, Rab1B contributes to the regulation of autophagic and secretory pathways. It interacts with proteins such as MTMR6, which influences its subcellular localization and function in both early secretory and autophagic processes. In malignant contexts, Rab1B is redirected by factors like PITPNC1 to the Golgi to recruit effectors (e.g. GOLPH3) that promote Golgi extension and enhanced vesicular release; additionally, its direct binding to internal ribosome entry site (IRES) RNA elements localizes transcripts near ER–Golgi membranes and consequently stimulates IRES‐dependent translation. Moreover, long noncoding RNAs such as LINC00173 have been shown to interface with Rab1B, thereby facilitating the extracellular secretion of pro-tumorigenic factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRab1B also plays multifaceted roles in disease processes, acting at the crossroads between host–pathogen interactions, innate immune responses, and cancer progression. In bacterial infections, pathogens like Legionella pneumophila manipulate Rab1B activity via effectors such as LepB and Lem3 to inactivate or remodel host vesicular traffic. In parallel, Rab1B facilitates antiviral defenses by forming complexes with TRAF3 that promote RIG-I pathway signaling and interferon‐β induction. In oncogenic contexts, disparate studies report that Rab1B may serve as a metastasis suppressor in triple‐negative breast cancer by promoting ubiquitin‐dependent degradation of TGF‑β receptor 1, whereas its overexpression in colorectal cancer correlates with deeper invasion and poorer patient outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pablo Monetta, Ileana Slavin, Nahuel Romero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e06-11-1005"}], "href": "https://doi.org/10.1091/mbc.e06-11-1005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17429068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17429068"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Helen L Zenner, Shin-Ichiro Yoshimura, Francis A Barr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00500-11"}], "href": "https://doi.org/10.1128/JVI.00500-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21680502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21680502"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Soichiro Kakuta, Junji Yamaguchi, Chigure Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201601052R"}], "href": "https://doi.org/10.1096/fj.201601052R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28522593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28522593"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Constantin N Takacs, Ursula Andreo, Viet Loan Dao Thi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.09.053"}], "href": "https://doi.org/10.1016/j.celrep.2017.09.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29020629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29020629"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yasuhiro Mochizuki, Riuko Ohashi, Takeshi Kawamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.395087"}], "href": "https://doi.org/10.1074/jbc.M112.395087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23188820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23188820"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nils Halberg, Caitlin A Sengelaub, Kristina Navrazhina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.02.013"}], "href": "https://doi.org/10.1016/j.ccell.2016.02.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26977884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26977884"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yazhou Li, Yang Liu, Feiyu Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Rap1b Enhances Apoptosis and Autophagy in Gastric Cancer Cells via the PI3K/Akt/mTOR Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14648701447779"}], "href": "https://doi.org/10.3727/096504016X14648701447779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27712585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27712585"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Javier Fernandez-Chamorro, Rosario Francisco-Velilla, Jorge Ramajo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES-driven RNA localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.201800131"}], "href": "https://doi.org/10.26508/lsa.201800131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30655362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30655362"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shi-Wei He, Ye-Lin Liang, Yuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00173 facilitates tumor progression by stimulating RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.13375"}], "href": "https://doi.org/10.1002/1878-0261.13375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36606322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36606322"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Emerich Mihai Gazdag, Alexandra Streller, Ina Haneburger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2012.211"}], "href": "https://doi.org/10.1038/embor.2012.211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23288104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23288104"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hong-Lin Jiang, He-Fen Sun, Shui-Ping Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3877"}], "href": "https://doi.org/10.18632/oncotarget.3877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25970785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25970785"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xian-Zi Yang, Shu-Zhong Cui, Li-Si Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101200"}], "href": "https://doi.org/10.18632/aging.101200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28316326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28316326"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Dia C Beachboard, Moonhee Park, Madhuvanthi Vijayan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor-associated factor 3 (TRAF3)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.007917"}], "href": "https://doi.org/10.1074/jbc.RA119.007917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31375559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31375559"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Marietta S Kaspers, Vivian Pogenberg, Christian Pett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-023-37621-7"}], "href": "https://doi.org/10.1038/s41467-023-37621-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37076474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37076474"}]}]}]}
Proteins	RAB1B_HUMAN
NCBI Gene ID	81876
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAB1B has 7,521 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for RAB1B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAB1B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RAB1B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB1B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAB1B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAB1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RAB1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB1B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB1B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RAB1B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB1B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RAB1B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RAB1B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB1B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAB1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RAB1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RAB1B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAB1B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAB1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RAB1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RAB1B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RAB1B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAB1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAB1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAB1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAB1B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAB1B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RAB1B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAB1B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RAB1B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RAB1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAB1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAB1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RAB1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAB1B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RAB1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RAB1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.