{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRAD50 is a core component of the Mre11-Rad50-Nbs1 (MRN) complex that functions as a primary sensor of DNA double‐strand breaks (DSBs). Its long, flexible coiled-coil domains and zinc hook interface enable the MRN complex to engage in one‐dimensional diffusion along DNA, tether broken ends together, and undergo the conformational changes required for efficient recruitment and activation of the ATM kinase. These structural features and ATP‐binding properties are fundamental to RAD50’s role in detecting DNA damage and initiating an appropriate repair response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its damage‐sensing role, RAD50 is critical in orchestrating downstream repair processes. 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