RAD54L Gene

Name	RAD54-like (S. cerevisiae)
Description	The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRAD54L is a Swi2/Snf2 ATP‐dependent DNA translocase that plays a central role in homologous recombination and DNA double‐strand break repair. It binds to Holliday junction–like structures with high specificity and promotes their bidirectional branch migration in an ATPase‐dependent manner. In doing so, RAD54L not only facilitates the extension of heteroduplex DNA during strand invasion but also acts in concert with RAD51—stimulating its DNA pairing activity and, once repair is initiated, promoting the dissociation of RAD51 from dsDNA. Furthermore, RAD54L’s ability to remodel chromatin, particularly by enabling RAD51 to invade nucleosomal templates, is governed by intricate mechanisms such as oligomerization and regulated ATP hydrolysis, with its activity modulated by distinct structural domains and phosphorylation events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its biochemical functions, RAD54L has emerged as an influential factor in human disease, particularly in various cancers. Genetic variations and differential expression of RAD54L have been linked to clinical outcomes in pancreatic adenocarcinoma, where certain alleles correlate with reduced patient survival, and in other malignancies such as bladder cancer, lung adenocarcinoma, head and neck squamous cell carcinoma, choroid plexus carcinomas, and meningiomas. In these contexts, aberrant RAD54L function contributes to dysregulated cell cycle control, radioresistance, altered telomere dynamics, and enhanced oncogenic signaling via pathways including mTORC1; its expression is regulated by key transcription factors like E2F1 and Oct4. Moreover, while screening in familial chronic lymphocytic leukemia did not reveal a strong predisposition linked to RAD54L, studies in mesenchymal stem cells and models of alternative telomere lengthening indicate that proper RAD54L activity is critical for maintaining genomic stability. Intriguingly, recent evidence also suggests that modulating RAD54L expression may have therapeutic implications in non‐malignant conditions such as osteoarthritis, where overexpression can attenuate disease progression through downregulation of hypoxia-inducible and angiogenic factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dmitry V Bugreev, Olga M Mazina, Alexander V Mazin "}, {"type": "b", "children": [{"type": "t", "text": "Rad54 protein promotes branch migration of Holliday junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04889"}], "href": "https://doi.org/10.1038/nature04889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16862129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16862129"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhaoqing Zhang, Hua-Ying Fan, Joseph A Goldman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homology-driven chromatin remodeling by human RAD54."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1223"}], "href": "https://doi.org/10.1038/nsmb1223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17417655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17417655"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Olga M Mazina, Matthew J Rossi, Nicolas H Thomaä, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of human rad54 protein with branched DNA molecules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701992200"}], "href": "https://doi.org/10.1074/jbc.M701992200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17545145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17545145"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dmitry V Bugreev, Fumio Hanaoka, Alexander V Mazin "}, {"type": "b", "children": [{"type": "t", "text": "Rad54 dissociates homologous recombination intermediates by branch migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1268"}], "href": "https://doi.org/10.1038/nsmb1268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17660833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17660833"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matthew J Rossi, Alexander V Mazin "}, {"type": "b", "children": [{"type": "t", "text": "Rad51 protein stimulates the branch migration activity of Rad54 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800839200"}], "href": "https://doi.org/10.1074/jbc.M800839200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18617519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18617519"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shinichi Machida, Motoki Takaku, Masae Ikura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep04863"}], "href": "https://doi.org/10.1038/srep04863"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24798879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24798879"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jennifer M Mason, Kritika Dusad, William Douglass Wright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv175"}], "href": "https://doi.org/10.1093/nar/gkv175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25765654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25765654"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nadish Goyal, Matthew J Rossi, Olga M Mazina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-02497-x"}], "href": "https://doi.org/10.1038/s41467-017-02497-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29295984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29295984"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Paola E Leone, Marta Mendiola, Javier Alonso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-3-6"}], "href": "https://doi.org/10.1186/1471-2407-3-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12614485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12614485"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Suliman Al-Wahiby, Hiu-Pak Wong, P Slijepcevic "}, {"type": "b", "children": [{"type": "t", "text": "Shortened telomeres in murine scid cells expressing mutant hRAD54 coincide with reduction in recombination at telomeres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutat Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mrfmmm.2005.04.008"}], "href": "https://doi.org/10.1016/j.mrfmmm.2005.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15975611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15975611"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Donghui Li, Marsha Frazier, Douglas B Evans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2005.04.4206"}], "href": "https://doi.org/10.1200/JCO.2005.04.4206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16520463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16520463"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Donghui Li, Hui Liu, Li Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-3032"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-3032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16540687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16540687"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Koichi Akiyama, Kosuke Yusa, Hideharu Hashimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rad54 is dispensable for the ALT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2006.01020.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2006.01020.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17054727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17054727"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Gabrielle Sellick, Sarah Fielding, Mobshra Qureshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10428190701606800"}], "href": "https://doi.org/10.1080/10428190701606800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18203022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18203022"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Donghui Li, Hideo Suzuki, Bingrong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA repair gene polymorphisms and risk of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-08-1607"}], "href": "https://doi.org/10.1158/1078-0432.CCR-08-1607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19147782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19147782"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yiai Tong, Diana Merino, Birgit Nimmervoll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2015.04.005"}], "href": "https://doi.org/10.1016/j.ccell.2015.04.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25965574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25965574"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xuanwen Bao, Jing Wang, Guangming Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12867"}], "href": "https://doi.org/10.1002/2211-5463.12867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32333827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32333827"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jeong-Yeon Mun, Seung-Woo Baek, Won Young Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21239025"}], "href": "https://doi.org/10.3390/ijms21239025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33261027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33261027"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jacqueline Nathansen, Vasyl Lukiyanchuk, Linda Hein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01842-1"}], "href": "https://doi.org/10.1038/s41388-021-01842-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34079088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34079088"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Timucin Avsar, Rashid Mohiyuddin, Seyma Calis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of MTHFR, MTRR and RAD54L Gene Variations with Meningioma and Correlation with Tumor's Histopathological Characteristics on Turkish Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Turk Neurosurg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5137/1019-5149.JTN.33347-20.2"}], "href": "https://doi.org/10.5137/1019-5149.JTN.33347-20.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34169999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34169999"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Changjiang Liu, Wei Ren, Zhixin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00832-z"}], "href": "https://doi.org/10.1007/s13577-022-00832-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36454390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36454390"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zhengnan Li, Lifeng Xie, Longqiang Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0298575"}], "href": "https://doi.org/10.1371/journal.pone.0298575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38593124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38593124"}]}]}]}
Synonyms	RAD54A, HRAD54, HR54, HHR54
Proteins	RAD54_HUMAN
NCBI Gene ID	8438
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAD54L has 6,472 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for RAD54L from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAD54L Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAD54L gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAD54L gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAD54L gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAD54L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RAD54L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAD54L gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAD54L gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAD54L gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAD54L gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RAD54L gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAD54L gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAD54L gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAD54L gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAD54L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RAD54L gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RAD54L gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAD54L gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAD54L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RAD54L protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAD54L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAD54L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAD54L gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAD54L gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAD54L gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAD54L gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RAD54L protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAD54L gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for RAD54L protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RAD54L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAD54L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAD54L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RAD54L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAD54L gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAD54L gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RAD54L gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RAD54L from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RAD54L gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RAD54L gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RAD54L gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RAD54L gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.