{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRARA-AS1 is a long non‐coding RNA that has emerged as a critical regulator in cancer biology, displaying distinct expression patterns across various cancer types and directly correlating with patient prognosis. Bioinformatics analyses reveal that its expression is intricately linked with key immunological factors, including immune checkpoints and mismatch repair genes, suggesting that RARA-AS1 may modulate immune infiltration and might serve as an important biomarker for cancer diagnosis and immunotherapy strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In glioblastoma, detailed investigations employing short hairpin RNA–mediated knockdown of RARA-AS1 showed significant reductions in cell proliferation, invasion, and migration. These findings indicate that RARA-AS1 not only participates in the aggressive behavior of glioblastoma cells but also may act via RNA binding protein (RBP) mechanisms, potentially linking its function to relevant effective drugs and signaling pathways that govern tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Collectively, the study underscores RARA-AS1’s potential as an independent prognostic factor and promising therapeutic target, particularly in glioblastoma. Its multifaceted role—spanning immune regulation, tumor cell behavior, and responsiveness to drugs—positions RARA-AS1 as a pivotal player in pan‐cancer processes, thereby setting the stage for further mechanistic investigations and clinical applications in personalized cancer care."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Huang, Song Deng, Qiaoji Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RARA-AS1 could serve as a novel prognostic biomarker in pan-cancer and promote proliferation and migration in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-44677-4"}], "href": "https://doi.org/10.1038/s41598-023-44677-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37833349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37833349"}]}]}]}