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By directly binding and sequestering ligands such as transforming growth factor–β and myostatin, and by interacting with receptor tyrosine kinases (for example, the epidermal growth factor receptor, Met, PDGFRα, and IGF‐IR), decorin down‐regulates proliferative, fibrotic and angiogenic signals. This modulation of receptor activity not only promotes autophagy (with associated induction of tumor suppressor genes) but also underpins decorin’s broad anti‐tumorigenic and antiangiogenic properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, decorin’s multifaceted roles extend to modulating tissue repair, fibrosis, and immune responses. 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