Name | Ras association (RalGDS/AF-6) domain family member 1 |
Description | This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRASSF1A is a widely studied tumor suppressor that is most notably inactivated through promoter hypermethylation across an array of human cancers. Many investigations have demonstrated that aberrant methylation of the RASSF1A CpG island is an early and tumor‐specific event observed in lung, breast, kidney, pediatric, and even testicular neoplasms. Moreover, its silencing in tumor tissues and even in bodily fluids has promoted interest in its use as a noninvasive biomarker for early cancer detection and prognosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role as a diagnostic marker, RASSF1A functions as a critical mediator of pro‐apoptotic and cell cycle regulatory pathways. Through direct interactions with key kinases such as MST1/2 and the effector LATS1, it disrupts inhibitory complexes (for example, those formed by the Raf1 proto‐oncogene) to promote Bax activation and p73‐mediated transcription of apoptotic genes. RASSF1A thereby links death receptor signaling to mitochondrial apoptosis and regulates p53 stability by facilitating MDM2 self‐ubiquitination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRASSF1A also exerts control over mitotic progression and cytoskeletal dynamics. Its localization on microtubules, centrosomes, and the spindle apparatus enables it to regulate the stability of mitotic cyclins and delay progression through prometaphase by inhibiting APC/Cdc20 activity. Furthermore, interactions with proteins such as PMCA and associations with Rap1 suggest that RASSF1A participates in organizing macromolecular complexes that modulate integrin signaling and microtubule acetylation—processes that ultimately impact tumor cell growth and genomic stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered additional layers of regulation that fine‐tune RASSF1A function and its tumor suppressive capacity. Regulatory mechanisms now include modulation by long noncoding antisense transcripts that can recruit repressor complexes to the RASSF1A promoter, as well as TGF‐β–induced ubiquitin–proteasome degradation that limits its protein levels. In parallel, transcription factors such as HOXB3 have been implicated in driving DNMT3B expression and subsequent RASSF1A promoter hypermethylation. These novel insights link RASSF1A inactivation not only to cancer initiation but also to enhanced invasive phenotypes and altered therapeutic responsiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "38", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masayuki Hasegawa, Heather H Nelson, Edward Peters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Patterns of gene promoter methylation in squamous cell cancer of the head and neck."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205528"}], "href": "https://doi.org/10.1038/sj.onc.1205528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12082610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12082610"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kenichi Harada, Shinichi Toyooka, Anirban Maitra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205446"}], "href": "https://doi.org/10.1038/sj.onc.1205446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12082624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12082624"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoshio Tomizawa, Takashi Kohno, Haruhiko Kondo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12114441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12114441"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sofia Honorio, Angelo Agathanggelou, Marcus Schuermann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206057"}], "href": "https://doi.org/10.1038/sj.onc.1206057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12527916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12527916"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sofia Honorio, Angelo Agathanggelou, Nicolas Wernert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206119"}], "href": "https://doi.org/10.1038/sj.onc.1206119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12545168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12545168"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michael W Y Chan, Lung W Chan, Nelson L S Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent hypermethylation of promoter region of RASSF1A in tumor tissues and voided urine of urinary bladder cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.10971"}], "href": "https://doi.org/10.1002/ijc.10971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12594816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12594816"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "R Dammann, U Schagdarsurengin, M Strunnikova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18.665"}], "href": "https://doi.org/10.14670/HH-18.665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12647816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12647816"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mia Spugnardi, Stella Tommasi, Reinhard Dammann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12670917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12670917"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mary Jo Fackler, Megan McVeigh, Ella Evron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.11508"}], "href": "https://doi.org/10.1002/ijc.11508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14601057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14601057"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "R Dammann, U Schagdarsurengin, C Seidel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor RASSF1A in human carcinogenesis: an update."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-20.645"}], "href": "https://doi.org/10.14670/HH-20.645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15736067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15736067"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Winnie Yeo, Nathalie Wong, Wai-Lap Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Liver Int (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1478-3231.2005.01084.x"}], "href": "https://doi.org/10.1111/j.1478-3231.2005.01084.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15780049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15780049"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Angelo Agathanggelou, Wendy N Cooper, Farida Latif "}, {"type": "b", "children": [{"type": "t", "text": "Role of the Ras-association domain family 1 tumor suppressor gene in human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-04-4088"}], "href": "https://doi.org/10.1158/0008-5472.CAN-04-4088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15867337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15867337"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "G P Pfeifer, R Dammann "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of the tumor suppressor gene RASSF1A in human tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (Mosc) (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10541-005-0151-y"}], "href": "https://doi.org/10.1007/s10541-005-0151-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15948711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15948711"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Carmen J Marsit, Margaret R Karagas, Hadi Danaee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carcinogen exposure and gene promoter hypermethylation in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgi172"}], "href": "https://doi.org/10.1093/carcin/bgi172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15987713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15987713"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Naoki Yanagawa, Gen Tamura, Hiroyuki Oizumi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2007.05.011"}], "href": "https://doi.org/10.1016/j.lungcan.2007.05.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17606310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17606310"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jeffrey A Tsou, Janice S Galler, Kimberly D Siegmund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-6-70"}], "href": "https://doi.org/10.1186/1476-4598-6-70"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17967182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17967182"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Malcolm V Brock, Craig M Hooker, Emi Ota-Machida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation markers and early recurrence in stage I lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa0706550"}], "href": "https://doi.org/10.1056/NEJMoa0706550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18337602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18337602"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zhao-Hui Huang, Yu Hu, Dong Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative analysis of multiple methylated genes in plasma for the diagnosis and prognosis of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2011.08.004"}], "href": "https://doi.org/10.1016/j.yexmp.2011.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21884695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21884695"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Vera Kloten, Birte Becker, Kirsten Winner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr3375"}], "href": "https://doi.org/10.1186/bcr3375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23320751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23320751"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Alan W Partin, Leander Van Neste, Eric A Klein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical validation of an epigenetic assay to predict negative histopathological results in repeat prostate biopsies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Urol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.juro.2014.04.013"}], "href": "https://doi.org/10.1016/j.juro.2014.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24747657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24747657"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "A M Grawenda, E O'Neill "}, {"type": "b", "children": [{"type": "t", "text": "Clinical utility of RASSF1A methylation in human malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2015.221"}], "href": "https://doi.org/10.1038/bjc.2015.221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26158424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26158424"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Maria Strunnikova, Undraga Schagdarsurengin, Astrid Kehlen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.10.3923-3933.2005"}], "href": "https://doi.org/10.1128/MCB.25.10.3923-3933.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15870267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15870267"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Shairaz Baksh, Stella Tommasi, Sarah Fenton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.05.010"}], "href": "https://doi.org/10.1016/j.molcel.2005.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15949439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15949439"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Michele D Vos, Ashraf Dallol, Kristin Eckfeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RASSF1A tumor suppressor activates Bax via MOAP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512128200"}], "href": "https://doi.org/10.1074/jbc.M512128200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16344548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16344548"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hyun Jung Oh, Kyung-Kwon Lee, Su Jung Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-2951"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-2951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16510573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16510573"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Cai Guo, Stella Tommasi, Limin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2007.02.055"}], "href": "https://doi.org/10.1016/j.cub.2007.02.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17379520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17379520"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Claudia Seidel, Undraga Schagdarsurengin, Karen Blümke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.20317"}], "href": "https://doi.org/10.1002/mc.20317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17538946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17538946"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "David Matallanas, David Romano, Karen Yee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.08.008"}], "href": "https://doi.org/10.1016/j.molcel.2007.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17889669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17889669"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Sonja Thaler, Patricia S Hähnel, Arno Schad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1377"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19223555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19223555"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Garth Hamilton, Karen S Yee, Simon Scrace, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATM regulates a RASSF1A-dependent DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2009.10.040"}], "href": "https://doi.org/10.1016/j.cub.2009.10.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19962312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19962312"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "David Romano, David Matallanas, Gregory Weitsman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3147"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20086174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20086174"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Cai Guo, Xiaoying Zhang, Gerd P Pfeifer "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.178210"}], "href": "https://doi.org/10.1074/jbc.M110.178210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21199877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21199877"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Latha Shivakumar, John Minna, Toshiyuki Sakamaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.12.4309-4318.2002"}], "href": "https://doi.org/10.1128/MCB.22.12.4309-4318.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12024041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12024041"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Min Sup Song, Su Jeong Song, Nagi G Ayad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1091"}], "href": "https://doi.org/10.1038/ncb1091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14743218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14743218"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Lillian Shuk-Nga Chow, Kwok-Wai Lo, Joseph Kwong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.20079"}], "href": "https://doi.org/10.1002/ijc.20079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15027117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15027117"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Angel L Armesilla, Judith C Williams, Mamta H Buch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307557200"}], "href": "https://doi.org/10.1074/jbc.M307557200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15145946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15145946"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Ling Gao, Yunfeng Feng, Regina Bowers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-0254"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-0254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16912161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16912161"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Rajendra Kumar Palakurthy, Narendra Wajapeyee, Manas K Santra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.10.009"}], "href": "https://doi.org/10.1016/j.molcel.2009.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19854132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19854132"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Weizhu Zhu, Wenyi Qin, Ke Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutr Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/01635581.2012.654926"}], "href": "https://doi.org/10.1080/01635581.2012.654926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22332908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22332908"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Fatéméh Dubois, Maureen Keller, Olivier Calvayrac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-1008"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-1008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26759237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26759237"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Dafni-Eleftheria Pefani, Daniela Pankova, Aswin G Abraham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2016.05.012"}], "href": "https://doi.org/10.1016/j.molcel.2016.05.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27292796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27292796"}]}]}]}
|
Synonyms | NORE2A, REH3P21, RASSF1A, 123F2, RDA32 |
Proteins | RASF1_HUMAN |
NCBI Gene ID | 11186 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
RASSF1 has 10,408 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.
Click the + buttons to view associations for RASSF1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RASSF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of RASSF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of RASSF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of RASSF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RASSF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of RASSF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RASSF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RASSF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of RASSF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of RASSF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with RASSF1 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with RASSF1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RASSF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of RASSF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of RASSF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RASSF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing RASSF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing RASSF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing RASSF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing RASSF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with RASSF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with RASSF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of RASSF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with RASSF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with RASSF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with RASSF1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of RASSF1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by RASSF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving RASSF1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving RASSF1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with RASSF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with RASSF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RASSF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with RASSF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with RASSF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RASSF1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RASSF1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of RASSF1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing RASSF1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with RASSF1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with RASSF1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of RASSF1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with RASSF1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing RASSF1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of RASSF1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RASSF1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of RASSF1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RASSF1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of RASSF1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of RASSF1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving RASSF1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving RASSF1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving RASSF1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing RASSF1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing RASSF1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing RASSF1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by RASSF1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by RASSF1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by RASSF1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of RASSF1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of RASSF1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RASSF1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of RASSF1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of RASSF1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for RASSF1 protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of RASSF1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of RASSF1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of RASSF1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RASSF1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of RASSF1 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
HPO Gene-Disease Associations | phenotypes associated with RASSF1 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for RASSF1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with RASSF1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for RASSF1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of RASSF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate RASSF1 protein from the curated KEA Substrates of Kinases dataset. | |
KEGG Pathways | pathways involving RASSF1 protein from the KEGG Pathways dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate RASSF1 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of RASSF1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of RASSF1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with RASSF1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of RASSF1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of RASSF1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of RASSF1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RASSF1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing RASSF1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain RASSF1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by RASSF1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting RASSF1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of RASSF1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by RASSF1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for RASSF1 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of RASSF1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of RASSF1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing RASSF1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with RASSF1 gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for RASSF1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RASSF1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of RASSF1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving RASSF1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving RASSF1 protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with RASSF1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PhosphoSitePlus Phosphosite-Disease Associations | diseases associated with RASSF1 protein from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate RASSF1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
PID Pathways | pathways involving RASSF1 protein from the PID Pathways dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of RASSF1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of RASSF1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of RASSF1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of RASSF1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RASSF1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RASSF1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RASSF1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RASSF1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of RASSF1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of RASSF1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of RASSF1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of RASSF1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of RASSF1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RASSF1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of RASSF1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RASSF1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with RASSF1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with RASSF1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2024 | pathways involving RASSF1 protein from the WikiPathways Pathways 2024 dataset. | |