{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe long noncoding RNA ANRASSF1, transcribed antisense to the RASSF1 locus, appears to be a multifunctional regulator in cancer development. In gastric cancer, ANRASSF1 is significantly overexpressed in tumor tissues relative to adjacent normal tissues, suggesting that its up‐regulation is linked to disease progression and that it may serve as a promising diagnostic biomarker or therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, ANRASSF1 has been implicated in the epigenetic repression of the tumor-suppressive RASSF1A isoform through a locus-specific mechanism involving the recruitment of Polycomb Repressive Complex 2 (PRC2). Notably, demethylation treatments that up-regulate RASSF1A are coupled with an inverse change in ANRASSF1 levels, highlighting its potential role as a therapeutic target for modulating epigenetic control at the RASSF1 locus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Roghayeh Kangarlouei, Shiva Irani, Zahra Noormohammadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANRIL and ANRASSF1 long noncoding RNAs are upregulated in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28520"}], "href": "https://doi.org/10.1002/jcb.28520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30834580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30834580"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Naiade Calanca, Ana Paula Paschoal, Érika Prando Munhoz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ANRASSF1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in the regulation of alternative protein-coding transcripts "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RASSF1A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RASSF1C"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in human breast cancer cells: implications to epigenetic therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2019.1615355"}], "href": "https://doi.org/10.1080/15592294.2019.1615355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31062660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31062660"}]}]}]}