{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non‐coding RNA RBM5‑AS1 is aberrantly overexpressed in several cancer types, including oral squamous cell carcinoma and osteosarcoma. In OSCC, high expression of RBM5‑AS1 has been linked to enhanced proliferation, migration, and invasion, while in osteosarcoma it is emerging as a key modulator of tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, RBM5‑AS1 appears to act as an oncogenic regulator by interfacing with distinct molecular pathways. In hepatocellular carcinoma, RBM5‑AS1 recruits the polycomb repressive complex (PRC2) to elevate H3K27me3 at the promoters of tumor‐suppressive miR‑132/212, leading to their downregulation and promoting cell proliferation and invasion. In medulloblastoma, RBM5‑AS1 contributes to stemness and radioresistance through an interaction that stabilizes SIRT6 protein, thereby supporting cancer stem cell properties and survival under genotoxic stress. In breast cancer, its transcription is induced by hypoxia‐mediated RUNX2 activation and it facilitates tumorigenesis by activating the Wnt/β‑catenin pathway – stabilizing β‑catenin and promoting formation of the β‑catenin–TCF4 transcriptional complex."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies indicate that RBM5‑AS1 functions as a multifaceted oncogenic lncRNA that modulates key signaling pathways and epigenetic regulators to foster tumor initiation, aggressive behavior, and resistance to therapy. Such findings nominate RBM5‑AS1 as a promising target for diagnostic and therapeutic intervention across a spectrum of malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stephen R Wellard, Karen Schindler, Philip W Jordan "}, {"type": "b", "children": [{"type": "t", "text": "Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.248831"}], "href": "https://doi.org/10.1242/jcs.248831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33172986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33172986"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Biyong Deng, Runsang Pan, Xin Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5271291"}], "href": "https://doi.org/10.1155/2021/5271291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33816613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33816613"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jin-Yong Mu, Jun-Xiu Tian, Ying-Jie Chen "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA RBM5-AS1 promotes cell proliferation and invasion by epigenetically silencing miR-132/212 in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11649"}], "href": "https://doi.org/10.1002/cbin.11649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34019714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34019714"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chuanying Zhu, Keke Li, Mawei Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-021-01218-2"}], "href": "https://doi.org/10.1186/s40478-021-01218-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34225779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34225779"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xinping Li, Jingyan Yang, Ruiqi Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04536-y"}], "href": "https://doi.org/10.1038/s41419-022-04536-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35110544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35110544"}]}]}]}