{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAfter extensive review of the provided abstracts, there is no direct mention or characterization of RBMS3‐AS1 in any of the studies. The entire collection of literature focuses on various hepatobiliary transporters (notably MDR2/ABCB4), nuclear receptors, noncoding RNAs (for example, H19), and related signaling pathways that regulate bile formation, cholestasis, inflammation, fibrogenesis, and liver tumorigenesis. In other words, none of the cited abstracts include experimental or mechanistic insights regarding the function of the long noncoding RNA RBMS3‐AS1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies in the collection explore key mechanisms in liver pathophysiology, such as the role of inflammatory mediators, bile acid toxicity, and adaptive changes in transporter expression (including studies on ABCB4/ MDR2‐deficiency models, nuclear receptors like PPARα and THR, and the impact of noncoding RNAs such as H19). However, none of these investigations address RBMS3‐AS1. This underscores a gap in the current literature regarding any potential function or regulatory role for RBMS3‐AS1 in hepatic or biliary biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional reports in the provided collection further delineate the molecular pathways underlying cholestatic liver injury and fibrosis, including the interplay between genetic mutations, altered phospholipid transport, and the emergence of liver cancer. Yet, these studies remain silent on any contribution of RBMS3‐AS1, leaving its function in these settings undetermined by the current literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, the discussed studies also highlight numerous experimental models and potential therapeutic interventions targeting aspects of liver fibrosis and cholangiopathy, yet once again none amend or explore any regulatory or pathological role for RBMS3‐AS1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tineke Kok, Vincent W Bloks, Henk Wolters, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgv156"}], "href": "https://doi.org/10.1093/carcin/bgv156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26542370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26542370"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alexandra N Carey, Wujuan Zhang, Kenneth D R Setchell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/pr.2017.78"}], "href": "https://doi.org/10.1038/pr.2017.78"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28355206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28355206"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anca D Petrescu, Stephanie Grant, Gabriel Frampton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18112389"}], "href": "https://doi.org/10.3390/ijms18112389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29125588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29125588"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Julien Gautherot, Thierry Claudel, Frans Cuperus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thyroid hormone receptor β1 stimulates "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ABCB4"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " to increase biliary phosphatidylcholine excretion in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M084145"}], "href": "https://doi.org/10.1194/jlr.M084145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29895698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29895698"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yoshito Ikeda, Shin-Ya Morita, Ryo Hatano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Biol Lipids (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2019.06.001"}], "href": "https://doi.org/10.1016/j.bbalip.2019.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31176036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31176036"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Vik Meadows, Lindsey Kennedy, Laura Hargrove, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Knockout of the Tachykinin Receptor 1 in the Mdr2"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "-/-"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " (Abcb4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "-/-"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": ") Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2020.07.007"}], "href": "https://doi.org/10.1016/j.ajpath.2020.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32712019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32712019"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "W Smyk, S N Weber, R Hall, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2020.166067"}], "href": "https://doi.org/10.1016/j.bbadis.2020.166067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33418034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33418034"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Liangtao Ye, Andreas Ziesch, Julia S Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "-/-"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14336/AD.2023.0602"}], "href": "https://doi.org/10.14336/AD.2023.0602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37307826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37307826"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Irene Blázquez-García, Laura Guerrero, Cristina Cacho-Navas, et al. 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