RFPL1S Gene

Name RFPL1 antisense RNA 1
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMembers of the Fc receptor‐like (FCRL) family participate in fine-tuning B cell responses through diverse mechanisms. One such member, FCRL2, is a transmembrane receptor expressed predominantly by memory B cells. It contains two inhibitory immunoreceptor tyrosine‐based activation motifs (ITIMs) that, upon co‐engagement with the B cell receptor (BCR), become phosphorylated and recruit the Src homology 2 domain–containing phosphatase SHP-1 to attenuate BCR signaling. In this way, FCRL2 acts as a negative immunomodulator controlling B cell activation and maintaining immune homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, FcRY—a related gene identified via bioinformatics—encodes a protein predicted to consist of three immunoglobulin domains along with a mucin-like region, yet it lacks a classical hydrophobic transmembrane domain. This structural characteristic suggests that FcRY may function as either an intracellular or secreted molecule. Expression of FcRY is observed at low levels across multiple B cell developmental stages and is dynamically regulated; for instance, its expression diminishes following BCR or CD40 signaling but is transiently elevated upon treatment with BAFF/BLyS or LPS. This pattern links FcRY expression to cell cycle status and survival pathways in B cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, the cytosolic proteins FCRLA and FCRLB, which share homology with transmembrane Fc receptor-like proteins, appear to influence antibody responses. Although B cell development and in vitro activation remain largely intact in the absence of FCRLB, its deficiency correlates with enhanced T-dependent antibody responses. This effect is thought to arise from aberrant regulation of the inhibitory receptor FcγRIIb following B cell activation, likely as a consequence of altered promoter function inherited with the mutant Fcrlb allele. Such findings underscore the role of FCRLA/B in modulating B cell effector functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tanisha A Jackson, Christopher L Haga, Götz R A Ehrhardt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1002305"}], "href": "https://doi.org/10.4049/jimmunol.1002305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21068405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21068405"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Keiji Masuda, Randall S Davis, Takako Maruyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2005.08.016"}], "href": "https://doi.org/10.1016/j.gene.2005.08.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16263223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16263223"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Keiji Masuda, Hiromi Mori, Osamu Ohara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcγRIIb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellimm.2010.08.007"}], "href": "https://doi.org/10.1016/j.cellimm.2010.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20869045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20869045"}]}]}]}
Synonyms RFPL1-AS, NCRNA00006, RFPL1AS, RFPL1-AS1
NCBI Gene ID 10740
API
Download Associations
Predicted Functions View RFPL1S's ARCHS4 Predicted Functions.
Co-expressed Genes View RFPL1S's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RFPL1S's ARCHS4 Predicted Functions.

Functional Associations

RFPL1S has 1,781 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 29 datasets.

Click the + buttons to view associations for RFPL1S from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of RFPL1S gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of RFPL1S gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of RFPL1S gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RFPL1S gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of RFPL1S gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of RFPL1S gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with RFPL1S gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RFPL1S gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of RFPL1S gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RFPL1S gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RFPL1S gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RFPL1S gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of RFPL1S gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of RFPL1S gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing RFPL1S from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of RFPL1S gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RFPL1S gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RFPL1S gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of RFPL1S gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of RFPL1S gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RFPL1S gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of RFPL1S gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of RFPL1S gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of RFPL1S gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of RFPL1S gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for RFPL1S from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of RFPL1S gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RFPL1S gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of RFPL1S gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.