{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non‐coding RNA RGMB‑AS1 has emerged as a context‐dependent regulator in diverse cancers. In laryngeal squamous cell carcinoma, gastric cancer, and pancreatic cancer, RGMB‑AS1 is upregulated and contributes to oncogenesis by promoting cell proliferation, invasion, migration, and the epithelial–mesenchymal transition. Mechanistically, it functions as a competing endogenous RNA that sponges microRNAs—miR‑22 in laryngeal squamous cell carcinoma, miR‑22‑3p in gastric cancer, and miR‑574‑3p in pancreatic cancer—to upregulate oncogenic targets such as NLRP3, NFIB, and PIM3, respectively."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n \nIn contrast, studies in hepatocellular carcinoma and nasopharyngeal carcinoma indicate that RGMB‑AS1 may function as a tumor suppressor. In hepatocellular carcinoma, lower endogenous levels of RGMB‑AS1 are observed, and its forced upregulation suppresses cell proliferation, migration, and invasion while enhancing apoptosis and increasing expression of its sense partner RGMB—correlating with improved patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its role is also under exploration in papillary thyroid carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, in nasopharyngeal carcinoma, RGMB‑AS1 inhibits malignant behaviors and the EMT process via direct interaction with FOXA1, suggesting its potential utility as a prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n \nEmerging evidence in osteosarcoma further underscores the complex and cancer‐type–dependent function of RGMB‑AS1 in tumor progression, highlighting its promise as a novel biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenxing Xu, Kai Xi "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RGMB-AS1 promotes laryngeal squamous cell carcinoma cells progression via sponging miR-22/NLRP3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109222"}], "href": "https://doi.org/10.1016/j.biopha.2019.109222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31351424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31351424"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "W Zhang, F Zhan, D Li, et al. 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