RHOBTB2 Gene

HGNC Family	BTB (POZ) domain containing (BTBD), Ras small GTPases superfamily
Name	Rho-related BTB domain containing 2
Description	The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRHOBTB2, also known as DBC2, is an atypical member of the Rho GTPase family that functions predominantly as a tumor suppressor. Its expression is frequently lost in several human malignancies—including breast, gastric, lung, and bladder cancers—through mechanisms such as homozygous deletions, somatic mutations, and promoter hypermethylation. Loss of RHOBTB2 disrupts normal cell cycle regulation and apoptosis, in part by down‐regulating key mediators like Cyclin D1 and by orchestrating proteasome‐mediated protein degradation. In addition, RHOBTB2 influences the expression of chemokines involved in leukocyte migration and angiogenesis, and its transcription is directly regulated by factors such as E2F1, linking it to both the proliferative and apoptotic cascades. These deregulations correlate with enhanced tumor proliferation, impaired metastatic control, and overall poorer prognoses in cancer patients."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its critical tumor suppressive functions, RHOBTB2 plays an essential role in regulating protein homeostasis. It serves as a substrate‐specific adaptor for Cullin-3–based E3 ubiquitin ligase complexes, thereby directing the ubiquitination and subsequent proteasomal degradation of target proteins. Moreover, RHOBTB2 interacts with molecular chaperones such as Hsp90—which modulate its GTP-binding capacity and promote proper assembly of its E3 ligase complex—thus integrating post-translational control with intracellular trafficking processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, RHOBTB2 is pivotal in neurodevelopment. De novo missense variants that cluster in its BTB domain have been linked to developmental and epileptic encephalopathies characterized by early-onset seizures, severe intellectual disability, and movement disorders. These pathogenic variants appear to impair normal proteasomal degradation, which in turn disrupts dendritic arborization and neuronal network formation, accentuating the protein’s importance for proper brain development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masaaki Hamaguchi, Jennifer L Meth, Christine von Klitzing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DBC2, a candidate for a tumor suppressor gene involved in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.212516099"}], "href": "https://doi.org/10.1073/pnas.212516099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12370419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12370419"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Veeraiah Siripurapu, Jennifer Meth, Noriko Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2004.11.043"}], "href": "https://doi.org/10.1016/j.jmb.2004.11.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15663929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15663929"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takashi Yoshihara, Denise Collado, Masaaki Hamaguchi "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.05.037"}], "href": "https://doi.org/10.1016/j.bbrc.2007.05.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17517369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17517369"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Denise Collado, Takashi Yoshihara, Masaaki Hamaguchi "}, {"type": "b", "children": [{"type": "t", "text": "DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.06.127"}], "href": "https://doi.org/10.1016/j.bbrc.2007.06.127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17617377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17617377"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Ohadi, M Totonchi, P Maguire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation analysis of the DBC2 gene in sporadic and familial breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Oncol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/02841860601047752"}], "href": "https://doi.org/10.1080/02841860601047752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17653899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17653899"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yong Gu Cho, Byung Joon Choi, Chang Jae Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "DBC2 gene is silenced by promoter methylation in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol Oncol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urolonc.2007.08.009"}], "href": "https://doi.org/10.1016/j.urolonc.2007.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18640857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18640857"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "C M McKinnon, K A Lygoe, L Skelton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.317"}], "href": "https://doi.org/10.1038/onc.2008.317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18762809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18762809"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ye Bi, Ling Wei, Hai-ting Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expressions of Fas, CTLA-4 and RhoBTB2 genes in breast carcinoma and their relationship with clinicopathological factors]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19173804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19173804"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Haiting Mao, Xun Qu, Yongmei Yang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Ectopic expression of RhoBTB2 inhibits migration and invasion of human breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.10.11.13431"}], "href": "https://doi.org/10.4161/cbt.10.11.13431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20930524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20930524"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Haiting Mao, Lining Zhang, Yongmei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RhoBTB2 (DBC2) functions as tumor suppressor via inhibiting proliferation, preventing colony formation and inducing apoptosis in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2011.07.018"}], "href": "https://doi.org/10.1016/j.gene.2011.07.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21801820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21801820"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wei Dong, Long Meng, Hong-Chang Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of DBC2 expression is an early and progressive event in the development of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2012.13.5.2021"}], "href": "https://doi.org/10.7314/apjcp.2012.13.5.2021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22901165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22901165"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Linlin Han, Lin Hou, Jinlian Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of the DBC2 gene and its clinicopathological significance in breast cancer: correlation with aberrant DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotechnol Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10529-013-1190-x"}], "href": "https://doi.org/10.1007/s10529-013-1190-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23546941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23546941"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Weiwei Tang, Chuan Wang, Fangmeng Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RhoBTB2 gene in breast cancer is silenced by promoter methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2013.1593"}], "href": "https://doi.org/10.3892/ijmm.2013.1593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24356943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24356943"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Guoping Fu, Haixin Wang, Hongmei Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mutation of DBC2 in breast cancer patients from the Han ethnic group in Eastern China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hematol Oncol Stem Cell Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.hemonc.2013.11.004"}], "href": "https://doi.org/10.1016/j.hemonc.2013.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24485767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24485767"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Peng Liu, Qinghai Ma, Hanxiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of RHOBTB2 aberration as an independent prognostic indicator in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203087"}], "href": "https://doi.org/10.18632/aging.203087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34074803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34074803"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Faith K Chang, Noriko Sato, Noriko Kobayashi-Simorowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DBC2 is essential for transporting vesicular stomatitis virus glycoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2006.09.026"}], "href": "https://doi.org/10.1016/j.jmb.2006.09.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17023000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17023000"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jacob R Manjarrez, Liang Sun, Thomas Prince, et al. 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"}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RHOBTB2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000011543"}], "href": "https://doi.org/10.1212/WNL.0000000000011543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33504645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33504645"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Franziska Langhammer, Reza Maroofian, Rueda Badar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gim.2023.100885"}], "href": "https://doi.org/10.1016/j.gim.2023.100885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37165955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37165955"}]}]}]}
Synonyms	DBC2, EIEE64
Proteins	RHBT2_HUMAN
NCBI Gene ID	23221
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RHOBTB2 has 5,654 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for RHOBTB2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RHOBTB2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RHOBTB2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RHOBTB2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RHOBTB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RHOBTB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RHOBTB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RHOBTB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RHOBTB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RHOBTB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RHOBTB2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RHOBTB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RHOBTB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RHOBTB2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RHOBTB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RHOBTB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RHOBTB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RHOBTB2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RHOBTB2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RHOBTB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RHOBTB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RHOBTB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RHOBTB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RHOBTB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RHOBTB2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RHOBTB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RHOBTB2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RHOBTB2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RHOBTB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RHOBTB2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RHOBTB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RHOBTB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RHOBTB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RHOBTB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RHOBTB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RHOBTB2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RHOBTB2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RHOBTB2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RHOBTB2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RHOBTB2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RHOBTB2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RHOBTB2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.