{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRHPN1‐AS1 is a long non‐coding RNA that is frequently upregulated in a range of malignancies, including uveal melanoma, cervical cancer, breast cancer, hepatocellular carcinoma, endometrial cancer, retinoblastoma, and more, as highlighted by several studies. Its increased expression has been consistently associated with enhanced tumor cell proliferation, migration, invasion, and in vivo tumor growth, thereby serving as an oncogenic factor and potential prognostic biomarker. These findings underscore the importance of RHPN1‐AS1 as a contributor to tumorigenesis and a promising candidate for targeted therapy approaches."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, RHPN1‐AS1 exerts its oncogenic effects primarily via a competing endogenous RNA (ceRNA) mechanism. It acts as a molecular sponge for multiple microRNAs, thereby de‐repressing key oncogenic targets. For example, in breast cancer it sequesters miR‑4261 to modulate p53 expression through MDM2 regulation, while in prostate cancer it binds miR‑7‑5p, leading to upregulation of EGFR and activation of downstream PI3K/AKT/mTOR signaling that suppresses apoptosis and alters autophagy. Moreover, in ovarian and nasopharyngeal carcinomas, RHPN1‐AS1 sponges miRNAs such as miR‑1684‑5p, miR‑1485‑5p, and miR‑485‑5p to elevate the expression of oncogenes including TOP2A and TPX2 and to influence CELF2 levels and mTORC1 pathway activity. These interactions collectively drive key malignant phenotypes including enhanced proliferation, adhesion, migration, chemoresistance, and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_fs", "start_ref": "8", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies validate the multifaceted role of RHPN1‐AS1 in cancer biology and highlight its clinical significance. By orchestrating key oncogenic pathways via microRNA sponging and subsequent deregulation of pivotal effector proteins, RHPN1‐AS1 not only promotes tumor progression and chemoresistance but also represents an attractive therapeutic target. Targeting RHPN1‐AS1 or its downstream regulatory networks may offer new avenues for precision oncology in multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Linna Lu, Xiaoyu Yu, Leilei Zhang, et al. 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