HGNC Family | C2 domain containing |
Name | regulating synaptic membrane exocytosis 4 |
Description | Predicted to enable transmembrane transporter binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in several processes, including regulation of synapse organization; regulation of synaptic vesicle exocytosis; and synaptic vesicle exocytosis. Predicted to be located in synaptic membrane. Predicted to be active in glutamatergic synapse; presynaptic active zone cytoplasmic component; and presynaptic membrane. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided collection of abstracts does not mention RIMS4. Instead, they focus on specialized translesion synthesis (TLS) DNA polymerases—including REV1, Polkappa, Poliota, and others—and their roles in bypassing DNA lesions to preserve genome integrity. In these studies, REV1 is shown to act as an essential scaffolding protein that coordinates multiple TLS polymerases via its C‐terminal domain, which interacts with short “REV1‐interacting regions” (RIRs) present in Polkappa, Poliota, and other Y‐family polymerases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This network of interactions facilitates nucleotide insertion opposite various DNA lesions such as UV–induced photoproducts, bulky chemical adducts, and oxidative modifications, thereby allowing replication to proceed despite template damage.\n \nFurther structural and functional analyses reveal that REV1’s C-terminal domain adopts a defined fold upon binding RIR peptides and simultaneously provides a binding surface for the Rev7 subunit of DNA polymerase ζ, a key participant in extending from the inserted nucleotide."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Meanwhile, Polkappa not only contributes to the direct bypass of specific lesions—such as bulky benzo[a]pyrene adducts and oxidatively damaged bases—but also appears to have roles in additional repair pathways including nucleotide excision repair and replication fork recovery. Its activity is modulated by interactions with monoubiquitinated PCNA and may require its unique structural domains (e.g., the N-clasp) for efficient and accurate TLS."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n \nIn vivo studies spanning various mouse genetic models further underscore the physiological significance of these polymerases. For example, loss-of-function or inactivation of Polkappa results in enhanced sensitivity to a range of DNA-damaging agents, increased mutation frequencies, and aberrant checkpoint activation, which together signify its crucial role in accurate lesion bypass and genome maintenance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": " Complementary studies have dissected the structural determinants enabling these polymerases to interact, revealing that minor alterations in their interaction motifs or catalytic domains can markedly affect their biochemical activity and the overall TLS process."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n \nFurther structural characterization of the REV1 C-terminal domain and its complex with the RIR of Polkappa has provided detailed insights into how this assembly orchestrates the switch between the insertion and extension steps during TLS, a mechanism that is critical for minimizing mutagenesis while allowing replication to continue past DNA damage."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": " Additional work comparing variant forms of Polkappa emphasizes that specific regions—including its extreme N-terminal sequences—are required not only for maintaining catalytic efficiency and fidelity during TLS but also for proper recovery from replication stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": "\n \nFinally, investigations into the genotoxic response in Polkappa-mutant mice highlight that while Polkappa is critical for suppressing mutations induced by various environmental carcinogens, its absence can lead to distinct mutation signatures in different tissues, thus confirming its multifaceted role in DNA damage tolerance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n \nIn summary, although none of these studies provide information on RIMS4, they collectively demonstrate that the coordinated function and regulation of specialized TLS polymerases—through precise protein–protein interactions and domain-specific structural features—are essential for efficient lesion bypass, genome stability, and cell survival in the face of DNA damage.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tomoo Ogi, Yoichi Shinkai, Kiyoji Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.222377899"}], "href": "https://doi.org/10.1073/pnas.222377899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12432099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12432099"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Caixia Guo, Paula L Fischhaber, Margaret J Luk-Paszyc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg626"}], "href": "https://doi.org/10.1093/emboj/cdg626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14657033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14657033"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Caixia Guo, Tianshu Gao, Nils Confer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple PolK (POLK) transcripts in mammalian testis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2004.10.006"}], "href": "https://doi.org/10.1016/j.dnarep.2004.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15661663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15661663"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaohui Bi, Damien M Slater, Haruo Ohmori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M501562200"}], "href": "https://doi.org/10.1074/jbc.M501562200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15817457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15817457"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takeyuki Shimizu, Takachika Azuma, Mariko Ishiguro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imlet.2004.11.022"}], "href": "https://doi.org/10.1016/j.imlet.2004.11.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15860226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15860226"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Paweł Jałoszyński, Eiji Ohashi, Haruo Ohmori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Error-prone and inefficient replication across 8-hydroxyguanine (8-oxoguanine) in human and mouse ras gene fragments by DNA polymerase kappa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2005.00858.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2005.00858.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15938713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15938713"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Katsuya Takenaka, Tomoo Ogi, Takashi Okada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506153200"}], "href": "https://doi.org/10.1074/jbc.M506153200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16308320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16308320"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Karen L-A Burr, Susana Velasco-Miguel, Venkata S Duvvuri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated mutation rates in the germline of Polkappa mutant male mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2006.04.003"}], "href": "https://doi.org/10.1016/j.dnarep.2006.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16731053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16731053"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tomoo Ogi, Alan R Lehmann "}, {"type": "b", "children": [{"type": "t", "text": "The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1417"}], "href": "https://doi.org/10.1038/ncb1417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16738703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16738703"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Caixia Guo, Tie-Shan Tang, Marzena Bienko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709275200"}], "href": "https://doi.org/10.1074/jbc.M709275200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18162470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18162470"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eiji Ohashi, Tomo Hanafusa, Keijiro Kamei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2008.01255.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2008.01255.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19170759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19170759"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "J Nicole Kosarek Stancel, Lisa D McDaniel, Susana Velasco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polk mutant mice have a spontaneous mutator phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2009.09.003"}], "href": "https://doi.org/10.1016/j.dnarep.2009.09.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19783230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19783230"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Bifeng Yuan, Changjun You, Nisana Andersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.232835"}], "href": "https://doi.org/10.1074/jbc.M111.232835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454642"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hannah L Williams, Max E Gottesman, Jean Gautier "}, {"type": "b", "children": [{"type": "t", "text": "Replication-independent repair of DNA interstrand crosslinks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.05.001"}], "href": "https://doi.org/10.1016/j.molcel.2012.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22658724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22658724"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jessica Wojtaszek, Jiangxin Liu, Sanjay D'Souza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.380998"}], "href": "https://doi.org/10.1074/jbc.M112.380998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22700975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22700975"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jessica Wojtaszek, Chul-Jin Lee, Sanjay D'Souza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.394841"}], "href": "https://doi.org/10.1074/jbc.M112.394841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22859295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22859295"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiuli Zhang, Lingna Lv, Qian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2013.02.008"}], "href": "https://doi.org/10.1016/j.dnarep.2013.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23522793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23522793"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yang Liu, Yeran Yang, Tie-Shan Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1324168111"}], "href": "https://doi.org/10.1073/pnas.1324168111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24449898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24449898"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Akira Takeiri, Naoko A Wada, Shigeki Motoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo evidence that DNA polymerase kappa is responsible for error-free bypass across DNA cross-links induced by mitomycin C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2014.09.002"}], "href": "https://doi.org/10.1016/j.dnarep.2014.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25303778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25303778"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yang Liu, Xiaolu Ma, Caixia Guo "}, {"type": "b", "children": [{"type": "t", "text": "Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvv118"}], "href": "https://doi.org/10.1093/jb/mvv118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26634445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26634445"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kenichi Masumura, Naomi Toyoda-Hokaiwado, Naoko Niimi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene-induced genotoxicity in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Mol Mutagen (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/em.22146"}], "href": "https://doi.org/10.1002/em.22146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29076178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29076178"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Atsushi Hakura, Hajime Sui, Jiro Sonoda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA polymerase kappa counteracts inflammation-induced mutagenesis in multiple organs of mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Mol Mutagen (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/em.22272"}], "href": "https://doi.org/10.1002/em.22272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30620413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30620413"}]}]}]}
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Synonyms | C20ORF190, RIM4, RIM4-GAMMA, RIM4GAMMA, RIM 4, RIM-4 |
Proteins | RIMS4_HUMAN |
NCBI Gene ID | 140730 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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RIMS4 has 3,232 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets.
Click the + buttons to view associations for RIMS4 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RIMS4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of RIMS4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of RIMS4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of RIMS4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RIMS4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RIMS4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of RIMS4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of RIMS4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RIMS4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of RIMS4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of RIMS4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing RIMS4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing RIMS4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with RIMS4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with RIMS4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of RIMS4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with RIMS4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with RIMS4 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by RIMS4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with RIMS4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RIMS4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RIMS4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RIMS4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of RIMS4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing RIMS4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with RIMS4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing RIMS4 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of RIMS4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RIMS4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of RIMS4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RIMS4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of RIMS4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of RIMS4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving RIMS4 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving RIMS4 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving RIMS4 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing RIMS4 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing RIMS4 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing RIMS4 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by RIMS4 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of RIMS4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of RIMS4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RIMS4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of RIMS4 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with RIMS4 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with RIMS4 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of RIMS4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of RIMS4 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of RIMS4 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of RIMS4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RIMS4 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for RIMS4 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with RIMS4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for RIMS4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of RIMS4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of RIMS4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with RIMS4 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of RIMS4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing RIMS4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain RIMS4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by RIMS4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting RIMS4 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of RIMS4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of RIMS4 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for RIMS4 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RIMS4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of RIMS4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of RIMS4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RIMS4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RIMS4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RIMS4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
SynGO Synaptic Gene Annotations | synaptic terms associated with RIMS4 gene from the SynGO Synaptic Gene Annotations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of RIMS4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of RIMS4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of RIMS4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of RIMS4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RIMS4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of RIMS4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with RIMS4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with RIMS4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |