RIN1 Gene

HGNC Family	VPS9 domain containing
Name	Ras and Rab interactor 1
Description	Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRIN1 is a multifunctional effector of Ras that plays a central role in modulating receptor trafficking and downstream signaling. Acting as a guanine nucleotide exchange factor for Rab5, RIN1 facilitates endocytosis and determines the fate of receptors—promoting degradation versus recycling of the epidermal growth factor receptor (EGFR) and also regulating insulin receptor internalization. In doing so, RIN1 impacts the magnitude and duration of growth factor signaling that ultimately influences cellular proliferation and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond receptor trafficking, RIN1 functions as a critical adaptor in a broader spectrum of intracellular signaling. It directly activates ABL kinases to modulate actin remodeling and cell migration, while its activity is finely tuned by phosphorylation events mediated by kinases such as protein kinase D and by prostaglandin E₂–stimulated pathways. RIN1 also serves as a scaffold for recruiting partners including Smad2 and mitofusin 2—thereby promoting mitochondrial fusion and maintaining metabolic homeostasis. Detailed structural analyses of its Vps9 domain have pinpointed specific residues essential for proper Rab5 activation, and alternative splicing produces isoforms with potentially distinct regulatory roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, aberrations in RIN1 expression have been associated with a variety of human cancers. In some settings, downregulation of RIN1 correlates with enhanced tumor cell invasion and poor patient outcomes—as observed in breast, gastric, lung, colorectal cancers, and melanoma—while in other contexts upregulation supports oncogenic signaling via enhanced EGFR or BCR–ABL activity, contributing to malignancy in chronic myeloid leukemia and clear cell renal cell carcinoma. These findings indicate that RIN1 not only influences critical cellular processes—ranging from receptor endocytosis to cytoskeletal remodeling and mitochondrial dynamics—but also serves as a promising prognostic biomarker and potential therapeutic target in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kavitha Balaji, Chelsea Mooser, Christine M Janson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.113688"}], "href": "https://doi.org/10.1242/jcs.113688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22976291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22976291"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chen Kong, Xiong Su, Pin-I Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M611538200"}], "href": "https://doi.org/10.1074/jbc.M611538200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17403676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17403676"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C M Hunker, H Giambini, A Galvis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rin1 regulates insulin receptor signal transduction pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2005.12.021"}], "href": "https://doi.org/10.1016/j.yexcr.2005.12.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16457816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16457816"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jin C Tomshine, Sandra R Severson, Dennis A Wigle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell proliferation and epidermal growth factor signaling in non-small cell lung adenocarcinoma cell lines are dependent on Rin1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.033514"}], "href": "https://doi.org/10.1074/jbc.M109.033514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19570984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19570984"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "W Zhang, M L Veisaga, M A Barbieri "}, {"type": "b", "children": [{"type": "t", "text": "Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112318"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33069695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33069695"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sanjay Kumar, Christopher C Pan, Nirav Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2016.04.010"}], "href": "https://doi.org/10.1016/j.molcel.2016.04.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27184078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27184078"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Susanne Ziegler, Tim Eiseler, Rolf-Peter Scholz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-05-0427"}], "href": "https://doi.org/10.1091/mbc.E10-05-0427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21209314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21209314"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Adriana Galvis, Valeria Balmaceda, Hugo Giambini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of early endosome fusion by Rab5-binding defective Ras interference 1 mutants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2008.11.009"}], "href": "https://doi.org/10.1016/j.abb.2008.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19032933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19032933"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Adriana Galvis, Hugo Giambini, Zoilmar Villasana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional determinants of ras interference 1 mutants required for their inhbitory activity on endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2008.12.003"}], "href": "https://doi.org/10.1016/j.yexcr.2008.12.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19118546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19118546"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Casimiro Gerarduzzi, QingWen He, Beibei Zhai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.25412"}], "href": "https://doi.org/10.1002/jcp.25412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27137893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27137893"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Masako Fujioka, Takanori Goi, Yasuo Hirono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning of a novel splicing variant of RIN1 and its expression in gastric and colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504009789745566"}], "href": "https://doi.org/10.3727/096504009789745566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19806790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19806790"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marc Milstein, Chelsea K Mooser, Hailiang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIN1 is a breast tumor suppressor gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-1147"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-1147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18089779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18089779"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Guang-yi Shan, Zhe Zhang, Qi-guang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-011-0311-1"}], "href": "https://doi.org/10.1007/s13277-011-0311-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22249975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22249975"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Qun Wang, Ying Gao, Yufu Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of RIN1 gene expression in human non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Histochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.acthis.2011.08.008"}], "href": "https://doi.org/10.1016/j.acthis.2011.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21925717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21925717"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Katsunori Senda, Takanori Goi, Yasuo Hirono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of RIN1 gene expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17390061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17390061"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "M Thai, P Y Ting, J McLaughlin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2010.268"}], "href": "https://doi.org/10.1038/leu.2010.268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21102429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21102429"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ping Fang, Zigang Zhao, Hongfang Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIN1 exhibits oncogenic property to suppress apoptosis and its aberrant accumulation associates with poor prognosis in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-012-0402-7"}], "href": "https://doi.org/10.1007/s13277-012-0402-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22627834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22627834"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zi-Hao Feng, Yong Fang, Liang-Yun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13297"}], "href": "https://doi.org/10.1111/cas.13297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28612496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28612496"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Stefania Trino, Luciana De Luca, Vittorio Simeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3772-9"}], "href": "https://doi.org/10.1007/s13277-015-3772-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26194865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26194865"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Roland Osei Saahene, Precious Barnes, F A Yeboah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0301295"}], "href": "https://doi.org/10.1371/journal.pone.0301295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38635569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38635569"}]}]}]}
Proteins	RIN1_HUMAN
NCBI Gene ID	9610
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RIN1 has 6,469 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for RIN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RIN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RIN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RIN1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RIN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RIN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RIN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RIN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RIN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RIN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RIN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RIN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RIN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RIN1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RIN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RIN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RIN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RIN1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RIN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RIN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RIN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RIN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RIN1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RIN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RIN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RIN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RIN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RIN1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RIN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RIN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RIN1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RIN1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RIN1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RIN1 from the GeneSigDB Published Gene Signatures dataset.