RIPOR3 Gene

Name RIPOR family member 3
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNA modification is critical to proper cellular function, as illustrated by studies of enzymes such as TRMT2B. One study demonstrated that TRMT2B is responsible for m5U modifications in mitochondrial rRNAs and tRNAs, a process essential for the optimal activity of respiratory chain complexes I, III, and IV (for details, see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although this work focuses on mitochondrial RNA methylation, it highlights the broader importance of RNA‐related regulatory proteins.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a distinct line of investigation addressing tumorigenesis, RIPOR3 has emerged as a promising biomarker in tongue cancer, particularly in oral squamous cell carcinoma of the mobile tongue. Here, RIPOR3 expression was shown to be significantly associated with several clinicopathological features and overall survival; notably, lower RIPOR3 levels correlated with a poorer prognosis. Gene set enrichment and immune infiltration analyses further indicated that RIPOR3 is involved in modulating immune‐related pathways, and its downregulation appears linked to hypermethylation rather than copy number variations. Together, these findings suggest that high RIPOR3 expression is indicative of a more favorable tumor immune microenvironment and may serve as an independent prognostic factor in oral tongue cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ivan Laptev, Ekaterina Shvetsova, Sergey Levitskii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "5"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "U formation in both tRNA and rRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2019.1694733"}], "href": "https://doi.org/10.1080/15476286.2019.1694733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31736397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31736397"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kai Zhang, Junlong Da, Xiaoyao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated Expression of RIPOR3 Correlated with Immune Infiltrates Predicts Poor Prognosis in Oral Tongue Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.935055"}], "href": "https://doi.org/10.12659/MSM.935055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35277469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35277469"}]}]}]}
NCBI Gene ID 140876
API
Download Associations
Predicted Functions View RIPOR3's ARCHS4 Predicted Functions.
Co-expressed Genes View RIPOR3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RIPOR3's ARCHS4 Predicted Functions.

Functional Associations

RIPOR3 has 1,398 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.

Click the + buttons to view associations for RIPOR3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RIPOR3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with RIPOR3 gene from the CellMarker Gene-Cell Type Associations dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of RIPOR3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with RIPOR3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with RIPOR3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with RIPOR3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of RIPOR3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of RIPOR3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with RIPOR3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of RIPOR3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of RIPOR3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Kinase Library Tyrosine Kinome Atlas kinases that phosphorylate RIPOR3 protein from the Kinase Library Tyrosine Kinome Atlas dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of RIPOR3 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of RIPOR3 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of RIPOR3 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of RIPOR3 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of RIPOR3 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RIPOR3 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RIPOR3 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of RIPOR3 gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of RIPOR3 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of RIPOR3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with RIPOR3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.