{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRCOR1 is a key component of multiprotein corepressor complexes that regulate histone H3 lysine 4 demethylation and hence control lineage-specific gene expression during hematopoiesis. In erythroid and megakaryocytic differentiation, RCOR1 works in concert with LSD1 and transcription regulators (such as Gfi1b) to promote nucleosomal demethylation and drive proper erythroid maturation. In contrast, loss or imbalance of RCOR1—as seen when RCOR3 inhibits LSD1 activity or when RCOR1 is genetically ablated—leads to impaired erythroid differentiation, aberrant expression of stem‐ and myeloid-specific genes, and a shift from erythroid to myeloid cell fates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the developing brain, RCOR1, together with its paralog RCOR2, forms complexes with transcription factors such as INSM1. This partnership plays a crucial role in transitioning neural progenitors from a proliferative to a differentiated state, ensuring proper neuronal and oligodendroglial output as well as the correct morphogenesis of brain structures. Disruption of RCOR1/2 function in neural progenitors results in an excess of undifferentiated cells and structural malformations in the embryonic brain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system, RCOR1 functions within the CoREST complex in Foxp3+ regulatory T cells, where it associates with LSD1 and other core components to repress large sets of genes and maintain Treg identity and suppressive functions. Conditional deletion of RCOR1 in Tregs impairs their ability to curb immune responses—evident by altered cytokine profiles, diminished suppression of homeostatic proliferation, and enhanced antitumor immunity—thereby highlighting the importance of RCOR1 in immune homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huilan Yao, Devorah C Goldman, Tamilla Nechiporuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Corepressor Rcor1 is essential for murine erythropoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-11-538678"}], "href": "https://doi.org/10.1182/blood-2013-11-538678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24652990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24652990"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ghanshyam Upadhyay, Asif H Chowdhury, Bharat Vaidyanathan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1404292111"}], "href": "https://doi.org/10.1073/pnas.1404292111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24843136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24843136"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Caitlin E Monaghan, Tamilla Nechiporuk, Sophia Jeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1620230114"}], "href": "https://doi.org/10.1073/pnas.1620230114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28049845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28049845"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Xiong, Liqing Wang, Eros Di Giorgio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI131375"}], "href": "https://doi.org/10.1172/JCI131375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31917688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31917688"}]}]}]}