{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the collection of abstracts provided spans a wide array of topics—from aberrant kinase signaling in myeloproliferative disorders and intricate immunoregulatory mechanisms of the PD‐1/PD‐L1 axis to microRNA‐mediated modulation of gene expression and neuronal control of energy homeostasis—none of these studies directly mention or investigate RNA5S1. RNA5S1 is the gene that encodes the 5S ribosomal RNA, a highly conserved structural component of the large ribosomal subunit that is essential for ribosome assembly and proper protein synthesis. In the broader context of biomedical research, 5S rRNA plays an indispensable role in maintaining cellular protein production; however, its function was not a focus in any of the works cited here."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe themes emerging across these abstracts predominantly concern the regulation of cell signaling pathways, immune checkpoint interactions, and gene expression modulation—areas that are critical for understanding cancer progression, autoimmunity, and developmental processes. In contrast, RNA5S1, as the source of 5S rRNA, is fundamentally associated with the translational machinery of the cell. Its primary role involves integrating with ribosomal proteins to form a stable structural core that drives accurate ribosome function and protein biosynthesis. This housekeeping role is central to all cellular processes yet was not directly probed or linked to the pathologic and regulatory mechanisms discussed in the cited works."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn sum, while the abstracts collectively enhance our understanding of complex regulatory networks and disease mechanisms, they do not provide any experimental or conceptual insights into the function of RNA5S1. As RNA5S1 underpins the formation of ribosomal 5S rRNA—a critical molecule for the translation process and ribosome integrity—its function remains defined by its classical role in ribosome biogenesis and protein synthesis rather than by the immune or oncogenic pathways explored in these works. Future studies explicitly addressing ribosomal RNA dynamics may further clarify whether and how RNA5S1 might interface with the signaling and regulatory processes of disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lisa Ann Cirillo, Frank Robert Lin, Isabel Cuesta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(02)00459-8"}], "href": "https://doi.org/10.1016/s1097-2765(02"}, {"type": "t", "text": "00459-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11864602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11864602"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miguel Constância, Myriam Hemberger, Jennifer Hughes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental-specific IGF-II is a major modulator of placental and fetal growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature00819"}], "href": "https://doi.org/10.1038/nature00819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12087403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12087403"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoshiko Iwai, Masayoshi Ishida, Yoshimasa Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.192461099"}], "href": "https://doi.org/10.1073/pnas.192461099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12218188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12218188"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tomohide Yamazaki, Hisaya Akiba, Hideyuki Iwai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of programmed death 1 ligands by murine T cells and APC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.10.5538"}], "href": "https://doi.org/10.4049/jimmunol.169.10.5538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12421930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12421930"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing Zhang, Merav Socolovsky, Alec W Gross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-05-1479"}], "href": "https://doi.org/10.1182/blood-2003-05-1479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12907435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12907435"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "H Y Chen, M E Trumbauer, A S Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2003-1596"}], "href": "https://doi.org/10.1210/en.2003-1596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14962995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14962995"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Haidong Dong, Gefeng Zhu, Koji Tamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1074-7613(04)00050-0"}], "href": "https://doi.org/10.1016/s1074-7613(04"}, {"type": "t", "text": "00050-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15030776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15030776"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Soraya Yekta, I-Hung Shih, David P Bartel "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-directed cleavage of HOXB8 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1097434"}], "href": "https://doi.org/10.1126/science.1097434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15105502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15105502"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yvette E Latchman, Spencer C Liang, Yin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0307252101"}], "href": "https://doi.org/10.1073/pnas.0307252101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15249675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15249675"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chloé James, Valérie Ugo, Jean-Pierre Le Couédic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03546"}], "href": "https://doi.org/10.1038/nature03546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15793561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15793561"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Catherine S Lee, Joshua R Friedman, James T Fulmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The initiation of liver development is dependent on Foxa transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03649"}], "href": "https://doi.org/10.1038/nature03649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15959514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15959514"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wouter J de Jonge, Esmerij P van der Zanden, Frans O The, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1229"}], "href": "https://doi.org/10.1038/ni1229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16025117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16025117"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tadahiro Kitamura, Yun Feng, Yukari Ido Kitamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1392"}], "href": "https://doi.org/10.1038/nm1392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16604086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16604086"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mary E Keir, Spencer C Liang, Indira Guleria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue expression of PD-L1 mediates peripheral T cell tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20051776"}], "href": "https://doi.org/10.1084/jem.20051776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16606670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16606670"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jian Qun Ling, Tao Li, Ji Fan Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1123191"}], "href": "https://doi.org/10.1126/science.1123191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16614224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16614224"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Catherine Lacout, Didier F Pisani, Micheline Tulliez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-02-002030"}], "href": "https://doi.org/10.1182/blood-2006-02-002030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16670266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16670266"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sreenivasulu Kurukuti, Vijay Kumar Tiwari, Gholamreza Tavoosidana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0600326103"}], "href": "https://doi.org/10.1073/pnas.0600326103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16815976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16815976"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Manish J Butte, Mary E Keir, Theresa B Phamduy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.05.016"}], "href": "https://doi.org/10.1016/j.immuni.2007.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17629517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17629517"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Takeshi Azuma, Sheng Yao, Gefeng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-11-123141"}], "href": "https://doi.org/10.1182/blood-2007-11-123141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18223165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18223165"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Vania Parelho, Suzana Hadjur, Mikhail Spivakov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cohesins functionally associate with CTCF on mammalian chromosome arms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.01.011"}], "href": "https://doi.org/10.1016/j.cell.2008.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18237772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18237772"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Shawn D Blackburn, Haina Shin, Gordon J Freeman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0801497105"}], "href": "https://doi.org/10.1073/pnas.0801497105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18809920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18809920"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Shigeru Shibata, Miki Nagase, Shigetaka Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.1879"}], "href": "https://doi.org/10.1038/nm.1879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19029984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19029984"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Long Zhang, Thomas F Gajewski, Justin Kline "}, {"type": "b", "children": [{"type": "t", "text": "PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-03-206672"}], "href": "https://doi.org/10.1182/blood-2009-03-206672"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19417208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19417208"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Loise M Francisco, Victor H Salinas, Keturah E Brown, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-L1 regulates the development, maintenance, and function of induced regulatory T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20090847"}], "href": "https://doi.org/10.1084/jem.20090847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20008522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20008522"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yexica Aponte, Deniz Atasoy, Scott M Sternson "}, {"type": "b", "children": [{"type": "t", "text": "AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2739"}], "href": "https://doi.org/10.1038/nn.2739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21209617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21209617"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Michael J Krashes, Shuichi Koda, ChianPing Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapid, reversible activation of AgRP neurons drives feeding behavior in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI46229"}], "href": "https://doi.org/10.1172/JCI46229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21364278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21364278"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Youjin Lee, Amit Awasthi, Nir Yosef, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction and molecular signature of pathogenic TH17 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2416"}], "href": "https://doi.org/10.1038/ni.2416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22961052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22961052"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Stefani Spranger, Robbert M Spaapen, Yuanyuan Zha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3006504"}], "href": "https://doi.org/10.1126/scitranslmed.3006504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23986400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23986400"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Liufu Deng, Hua Liang, Byron Burnette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI67313"}], "href": "https://doi.org/10.1172/JCI67313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24382348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24382348"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20131916"}], "href": "https://doi.org/10.1084/jem.20131916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24778419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24778419"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Limo Chen, Don L Gibbons, Sangeeta Goswami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms6241"}], "href": "https://doi.org/10.1038/ncomms6241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25348003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25348003"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Elzo de Wit, Erica S M Vos, Sjoerd J B Holwerda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF Binding Polarity Determines Chromatin Looping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.09.023"}], "href": "https://doi.org/10.1016/j.molcel.2015.09.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26527277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26527277"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Matthew A Coelho, Sophie de Carné Trécesson, Sareena Rana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2017.11.016"}], "href": "https://doi.org/10.1016/j.immuni.2017.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29246442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29246442"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Haidong Tang, Yong Liang, Robert A Anders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI96061"}], "href": "https://doi.org/10.1172/JCI96061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29337303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29337303"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Heng Lin, Shuang Wei, Elaine M Hurt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI96113"}], "href": "https://doi.org/10.1172/JCI96113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29337305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29337305"}]}]}]}