RNF114 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 114
Description	Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGenome‐wide association studies have identified RNF114 (also known as ZNF313) as a psoriasis susceptibility gene. Specific variants (e.g. rs495337) and related markers are associated with both cutaneous and psoriatic arthritis forms, while expression analyses reveal high RNF114 levels in skin, T lymphocytes, and dendritic cells—supporting its putative role in immune regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional studies further demonstrate that RNF114 encodes a novel ubiquitin‐binding protein that modulates immune signaling. Over‐expression experiments show that RNF114 can enhance NF‑κB and IRF3 transcriptional activities and upregulate type I and type III interferon responses following double‐stranded RNA stimulation. In addition, RNF114 interacts with key signaling molecules—such as mitochondrial antiviral signaling protein (MAVS) and the ubiquitin‐editing enzyme A20—thereby influencing antiviral defense pathways and T cell activation. These findings implicate RNF114 as both a promoter of T cell activation and a modulator that can negatively regulate type‑I interferon production during viral infections."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations reveal a role for RNF114 as an E3 ubiquitin ligase involved in cell‐cycle regulation and p53‐mediated cell‐fate decisions. By ubiquitinating and promoting degradation of cyclin‐dependent kinase inhibitors such as p21, p27, and p57, RNF114 facilitates the timely transition from G1 to S phase and counteracts cellular senescence. Moreover, through its interactions with regulatory proteins like XAF1 and HIPK2, RNF114 contributes to a p53-dependent feedback loop that stresses an apoptotic outcome over cell‐cycle arrest during cellular stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, transcriptional studies indicate that RNF114’s (ZNF313’s) basal expression is tightly controlled in a tissue‐specific manner – with evidence from promoter analyses in testes suggesting roles in spermatogenesis – and that its deregulation may contribute to oncogenic processes, as seen in several human cancers including colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Philip E Stuart, Rajan P Nair, Eva Ellinghaus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association analysis identifies three psoriasis susceptibility loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.693"}], "href": "https://doi.org/10.1038/ng.693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20953189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20953189"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Francesca Capon, Marie-José Bijlmakers, Natalie Wolf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn091"}], "href": "https://doi.org/10.1093/hmg/ddn091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18364390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18364390"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Y-Y Feng, L-D Sun, C Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Dermatol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ced.12049"}], "href": "https://doi.org/10.1111/ced.12049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23617596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23617596"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marie-José Bijlmakers, Seshu K Kanneganti, Jonathan N Barker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr215"}], "href": "https://doi.org/10.1093/hmg/ddr215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21571784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21571784"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M S Rodriguez, I Egaña, F Lopitz-Otsoa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.366"}], "href": "https://doi.org/10.1038/cddis.2014.366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25165885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25165885"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ping Yang, Yilu Lu, Minhui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of RNF114 as a novel positive regulatory protein for T cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2014.02.002"}], "href": "https://doi.org/10.1016/j.imbio.2014.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24631332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24631332"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wenzheng Han, Qing Chen, Jun Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E3 ubiquitin ligase RNF114 promotes vesicular stomatitis virus replication via inhibiting type I interferon production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microb Pathog (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.micpath.2022.105569"}], "href": "https://doi.org/10.1016/j.micpath.2022.105569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35545202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35545202"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "J Han, Y-L Kim, K-W Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2013.33"}], "href": "https://doi.org/10.1038/cdd.2013.33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23645206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23645206"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Min-Goo Lee, Jikhyon Han, Seong-In Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1411746111"}], "href": "https://doi.org/10.1073/pnas.1411746111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25313037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25313037"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaolin Liao, Wenqian Deng, Yilu Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp1 plays an important role in regulating the transcription of ZNF313."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CBI20100216"}], "href": "https://doi.org/10.1042/CBI20100216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20515446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20515446"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shi-Cheng Liu, Le-Lan Gong, Feng-Chang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF114 facilitates the proliferation, stemness, and metastasis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2023.154716"}], "href": "https://doi.org/10.1016/j.prp.2023.154716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37523804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37523804"}]}]}]}
Synonyms	ZNF313, PSORS12
Proteins	RN114_HUMAN
NCBI Gene ID	55905
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF114 has 6,359 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for RNF114 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF114 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF114 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF114 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RNF114 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF114 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF114 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF114 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF114 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF114 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF114 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RNF114 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF114 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF114 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RNF114 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF114 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF114 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF114 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF114 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RNF114 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF114 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RNF114 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RNF114 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF114 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF114 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF114 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF114 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RNF114 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RNF114 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RNF114 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF114 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RNF114 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RNF114 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF114 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF114 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF114 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF114 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF114 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF114 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RNF114 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RNF114 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RNF114 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.