RNF216 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 216
Description	This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNF216, also known as Triad3A, is a RING‐type E3 ubiquitin ligase that orchestrates protein homeostasis by promoting the ubiquitination and subsequent degradation of select intracellular targets. Through its enzymatic activity, RNF216 modulates numerous cellular pathways—including those governing immune responses, synaptic function, autophagy, and reproductive development—by ensuring the timely removal of signaling proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\nIn the immune system, RNF216 fine‐tunes innate signaling by targeting key adaptor proteins and receptors. It catalyzes the Lys48‐linked ubiquitination of components such as TRAF3, TIRAP, TRIF, RIP1, and even receptors like TLR8—thereby attenuating Toll-like receptor and RIG-I-like receptor mediated responses and preventing excessive inflammation. RNF216 also interacts with viral proteins (for example, HIV-1 Vif), hinting at a broader role in antiviral defense."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n\nIn the nervous system, RNF216 is critical for proper synaptic plasticity and neuroendocrine regulation. It directly ubiquitinates synaptic proteins such as Arc/Arg3.1, thereby controlling AMPA receptor endocytosis and modulating synaptic strength. Loss-of-function mutations in RNF216 lead to Arc accumulation and have been implicated in neurodegenerative phenotypes that feature ataxia, cognitive decline, and hypogonadotropic hypogonadism (as seen in Gordon–Holmes syndrome). In addition, RNF216 interacts with RNA-binding partners like Staufen2, affecting GnRH signaling and thereby contributing to reproductive dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}, {"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n\nRNF216 also plays pivotal roles in maintaining cellular quality control beyond immune and neural cells. By mediating the ubiquitination of Beclin 1, a key autophagy regulator, it influences autophagic flux and cell survival; dysregulation of this axis has been linked to the progression of colorectal cancer. Moreover, genetic ablation and mutation studies in mouse models demonstrate that RNF216 is indispensable for proper spermatogenesis and meiotic progression—further underscoring its contributions to male fertility and the broader neuroendocrine network. Complementary clinical findings reveal a varied spectrum of RNF216-related disorders, including defects in central white matter integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Feng, Adam Davis, Julie-Anne Lake, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.78.19.10574-10581.2004"}], "href": "https://doi.org/10.1128/JVI.78.19.10574-10581.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15367624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15367624"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Colleen Fearns, Qilin Pan, John C Mathison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604019200"}], "href": "https://doi.org/10.1074/jbc.M604019200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16968706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16968706"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Peyman Nakhaei, Thibault Mesplede, Mayra Solis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1000650"}], "href": "https://doi.org/10.1371/journal.ppat.1000650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19893624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19893624"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S M Shahjahan Miah, Amanda K Purdy, Nicholas B Rodin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1000112"}], "href": "https://doi.org/10.4049/jimmunol.1000112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21270397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21270397"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Angela M Mabb, H Shawn Je, Mark J Wall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Triad3A regulates synaptic strength by ubiquitination of Arc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2014.05.016"}], "href": "https://doi.org/10.1016/j.neuron.2014.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24945773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24945773"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "John Evankovich, Travis Lear, Courtney Baldwin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toll-like Receptor 8 Stability Is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2018-0373OC"}], "href": "https://doi.org/10.1165/rcmb.2018-0373OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31385713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31385713"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nilofer Husain, Qiang Yuan, Yi-Chun Yen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12551"}], "href": "https://doi.org/10.1111/acel.12551"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27995769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27995769"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Thomas R Cotton, Simon A Cobbold, Jonathan P Bernardini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.12.005"}], "href": "https://doi.org/10.1016/j.molcel.2021.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34998453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34998453"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ke-Liang Chen, He Wang, Gui-Xian Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-Exome Sequencing Identified a Novel Mutation in RNF216 in a Family with Gordon Holmes Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-021-01953-0"}], "href": "https://doi.org/10.1007/s12031-021-01953-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35088240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35088240"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wenting Dai, Zuiming Jiang, Min Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Screening of interacting proteins of idiopathic gonadotropin-releasing hormone deficiency pathogenic gene RNF216]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn511374-20200731-00569"}], "href": "https://doi.org/10.3760/cma.j.cn511374-20200731-00569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34247365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34247365"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Han Yang, Yong Zhu, Xin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF216 affects the stability of STAU2 in the hypothalamus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Growth Differ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/dgd.12877"}], "href": "https://doi.org/10.1111/dgd.12877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37439148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37439148"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hui Wang, Yanan Wang, Liu Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF216 contributes to proliferation and migration of colorectal cancer via suppressing BECN1-dependent autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9433"}], "href": "https://doi.org/10.18632/oncotarget.9433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27203674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27203674"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Young Hun Kim, Man Sup Kwak, Jae Min Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflachromene inhibits autophagy through modulation of Beclin 1 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.211201"}], "href": "https://doi.org/10.1242/jcs.211201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29361549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29361549"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ashley F Melnick, Yuen Gao, Jiali Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF216 is essential for spermatogenesis and male fertility†."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/biolre/ioz006"}], "href": "https://doi.org/10.1093/biolre/ioz006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30649198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30649198"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dengfeng Li, Fangfang Li, Lanlan Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF216 regulates meiosis and PKA stability in the testes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202002294RR"}], "href": "https://doi.org/10.1096/fj.202002294RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33724554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33724554"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chujun Wu, Zaiqiang Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and genetic spectrum of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RNF216"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-related disorder: a new case and literature review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg-2023-109397"}], "href": "https://doi.org/10.1136/jmg-2023-109397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38050071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38050071"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wenqing Xu, Keliang Chen, Yiwen Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ring finger protein 216 loss-of-function induces white matter hyperintensities by inhibiting oligodendroglia proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.4057"}], "href": "https://doi.org/10.1002/cbf.4057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38853469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38853469"}]}]}]}
Synonyms	TRIAD3, CAHH, U7I1, UBCE7IP1
Proteins	RN216_HUMAN
NCBI Gene ID	54476
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF216 has 6,913 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for RNF216 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF216 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF216 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF216 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RNF216 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF216 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF216 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF216 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF216 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF216 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF216 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RNF216 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF216 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF216 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RNF216 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF216 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF216 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF216 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF216 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RNF216 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RNF216 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RNF216 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RNF216 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF216 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RNF216 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RNF216 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF216 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF216 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF216 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF216 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RNF216 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RNF216 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RNF216 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF216 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RNF216 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RNF216 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF216 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF216 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF216 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF216 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF216 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF216 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.