{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided literature reveals a wide spectrum of cellular and molecular functions that underlie processes as diverse as osteoclast differentiation, fibrogenesis, synaptic plasticity, immune cell activation, and tumor metastasis. Notably, these studies focus on protein‐coding regulators such as c‐Fos, galectin‑3, IL‑17 receptor components, and transcription factors like Onecut and Fra‑2, which govern critical signaling cascades in bone homeostasis, inflammation, neural activity, and organ remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, there is no discussion or experimental evidence in any of these studies that directly addresses the function of RNU1-2. In general, RNU1-2 is known to encode a small nuclear RNA (snRNA) that is typically a component of the spliceosome complex, contributing to pre-mRNA processing. However, none of the abstracts examined here mention or investigate splicing factors or snRNA-mediated regulation. Instead, the reports concentrate on the dynamics of transcriptional regulation, cytokine signalling, and cell‐to‐cell interactions in various disease and developmental models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies in the set extend these themes to include regulation of inflammatory responses in the central nervous system, mechanisms of immune regulation during autoimmune or infectious challenges, and contributions to tumorigenesis and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "27"}]}, {"type": "t", "text": " Furthermore, other reports elaborate on the roles of transcription factors and adaptor proteins in synaptic plasticity and memory formation as well as in integrin- and cytokine-mediated cell adhesion readouts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, while the aggregated research underscores multifaceted mechanisms that regulate cell fate, inflammatory signalling, and tissue remodeling across diverse physiological and pathological contexts, it does not provide any insights into the function of RNU1‑2. In consequence, based on the reviewed literature the role of RNU1‑2 remains unaddressed in these studies and may be inferred only from its canonical activity—as a fundamental component of the spliceosomal machinery—in processes not examined in these reports."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "33"}, {"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, additional studies that explore transcriptional regulators in differentiation and immune responses further reiterate that while many noncoding and coding factors contribute to the regulation of gene expression in varied contexts, the specific contributions of RNU1‑2 were not a subject of investigation in any of the provided abstracts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}, {"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "27"}, {"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianhua Zhang, Dongsheng Zhang, Jill Slane McQuade, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200981200"}], "href": "https://doi.org/10.1074/jbc.M200981200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12194966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12194966"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kurt Redlich, Silvia Hayer, Romeo Ricci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteoclasts are essential for TNF-alpha-mediated joint destruction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15582"}], "href": "https://doi.org/10.1172/JCI15582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12438440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12438440"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hideki Sano, Daniel K Hsu, John R Apgar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of galectin-3 in phagocytosis by macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI17592"}], "href": "https://doi.org/10.1172/JCI17592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12897206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12897206"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Koichi Matsuo, Deborah L Galson, Chen Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313973200"}], "href": "https://doi.org/10.1074/jbc.M313973200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15073183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15073183"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Galit Elad-Sfadia, Roni Haklai, Eyal Balan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312697200"}], "href": "https://doi.org/10.1074/jbc.M312697200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15205467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15205467"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Riaz I Zuberi, Daniel K Hsu, Omer Kalayci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)63255-5"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "63255-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15579447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15579447"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tamara Tanos, Maria Julia Marinissen, Federico Coluccio Leskow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M500620200"}], "href": "https://doi.org/10.1074/jbc.M500620200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15708845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15708845"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Neil C Henderson, Alison C Mackinnon, Sarah L Farnworth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 regulates myofibroblast activation and hepatic fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0511167103"}], "href": "https://doi.org/10.1073/pnas.0511167103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16549783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16549783"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dean Toy, David Kugler, Martin Wolfson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: interleukin 17 signals through a heteromeric receptor complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.1.36"}], "href": "https://doi.org/10.4049/jimmunol.177.1.36"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16785495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16785495"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "François Frenois, Maïté Moreau, Jason O'Connor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychoneuroendocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.psyneuen.2007.03.005"}], "href": "https://doi.org/10.1016/j.psyneuen.2007.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17482371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17482371"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Teruhito Yamashita, Zhenqiang Yao, Fang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M610701200"}], "href": "https://doi.org/10.1074/jbc.M610701200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17485464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17485464"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Marianna Papaspyridonos, Eileen McNeill, Joe P de Bono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.107.159160"}], "href": "https://doi.org/10.1161/ATVBAHA.107.159160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18096829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18096829"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Alison C MacKinnon, Sarah L Farnworth, Philip S Hodkinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of alternative macrophage activation by galectin-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.4.2650"}], "href": "https://doi.org/10.4049/jimmunol.180.4.2650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18250477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18250477"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jacky G Goetz, Bharat Joshi, Patrick Lajoie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200709019"}], "href": "https://doi.org/10.1083/jcb.200709019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18347068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18347068"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Gislâine A Martins, Luisa Cimmino, Jerry Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20080526"}], "href": "https://doi.org/10.1084/jem.20080526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18725523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18725523"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "José María González, Ana Navarro-Puche, Berta Casar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200805049"}], "href": "https://doi.org/10.1083/jcb.200805049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19015316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19015316"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hui-Rong Jiang, Zakeya Al Rasebi, Eric Mensah-Brown, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.182.2.1167"}], "href": "https://doi.org/10.4049/jimmunol.182.2.1167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19124760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19124760"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Huan-Yuan Chen, Agnes Fermin, Santosh Vardhana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0903497106"}], "href": "https://doi.org/10.1073/pnas.0903497106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19706535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19706535"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yan Hu, Naruhisa Ota, Ivan Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903614"}], "href": "https://doi.org/10.4049/jimmunol.0903614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20231694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20231694"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Allen W Ho, Fang Shen, Heather R Conti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903739"}], "href": "https://doi.org/10.4049/jimmunol.0903739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20554964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20554964"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Anna I Markowska, Fu-Tong Liu, Noorjahan Panjwani "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20090121"}], "href": "https://doi.org/10.1084/jem.20090121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20713592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20713592"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Sae-Bom Jeon, Hee Jung Yoon, Chi Young Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1000154"}], "href": "https://doi.org/10.4049/jimmunol.1000154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20980634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20980634"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Carla Iacobini, Stefano Menini, Carlo Ricci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2010.09.020"}], "href": "https://doi.org/10.1016/j.jhep.2010.09.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21145823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21145823"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Lili Yu, Willem P T Ruifrok, Maxi Meissner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Heart Fail (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCHEARTFAILURE.112.971168"}], "href": "https://doi.org/10.1161/CIRCHEARTFAILURE.112.971168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23230309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23230309"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Darshan Sapkota, Hemabindu Chintala, Fuguo Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1405354111"}], "href": "https://doi.org/10.1073/pnas.1405354111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25228773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25228773"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Pingping Li, Shuainan Liu, Min Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.10.025"}], "href": "https://doi.org/10.1016/j.cell.2016.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27814523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27814523"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Kong Chen, Taylor Eddens, Giraldina Trevejo-Nunez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2016.10.003"}], "href": "https://doi.org/10.1016/j.chom.2016.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27923703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27923703"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jian Jing Siew, Hui-Mei Chen, Huan-Yuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-11441-0"}], "href": "https://doi.org/10.1038/s41467-019-11441-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31375685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31375685"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Elmina Mammadova-Bach, Jesus Gil-Pulido, Edita Sarukhanyan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2019002649"}], "href": "https://doi.org/10.1182/blood.2019002649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32040544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32040544"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Bo Hu, Chengcheng Jin, Xing Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-020-2028-z"}], "href": "https://doi.org/10.1038/s41586-020-2028-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32076265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32076265"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Maurice Nachtigal, Abdul Ghaffar, Eugene P Mayer "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2008.070348"}], "href": "https://doi.org/10.2353/ajpath.2008.070348"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18156214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18156214"}]}]}]}