{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA large body of research has detailed the central role of focal adhesion kinase (FAK) in regulating diverse cellular functions including adhesion turnover, migration, mechanosensing, survival, proliferation, and the invasive and metastatic behavior of cancer cells. These studies describe how FAK activation—and its subsequent phosphorylation at key tyrosine residues—modulates integrin‐mediated signaling cascades, reorganizes the cytoskeleton, and orchestrates downstream events ranging from endothelial barrier restoration to neural circuit formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, while these abstracts provide extensive insight into the molecular circuitry and cellular outcomes governed by FAK and its interacting partners, none of them reference or assign any functional role to RNU1‐27P. RNU1‐27P is generally classified as a small nuclear RNA (snRNA) pseudogene, and its expression or potential regulatory impact is not discussed in the context of FAK‐mediated adhesion, migration, or signaling in any of the studies reviewed. Consequently, based on the current literature examined here, RNU1‐27P does not appear to contribute to or modulate the FAK‐dependent processes highlighted across these diverse cellular and pathological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ikuko Hayashi, Kristiina Vuori, Robert C Liddington "}, {"type": "b", "children": [{"type": "t", "text": "The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsb755"}], "href": "https://doi.org/10.1038/nsb755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11799401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11799401"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yunhao Liu, Joost C Loijens, Karen H Martin, et al. 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