{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided studies—which span a wide array of biomedical research areas including vascular biology, tissue repair, inflammation, fibrosis, cancer metastasis, neurodegeneration, and wound healing—reveals a prominent focus on the roles of specific microRNAs (especially miR‐126 and related species) and matrix metalloproteinases (notably MMP‐3) in orchestrating key cellular functions. These investigations demonstrate that endothelial‐restricted microRNAs regulate angiogenesis, vascular integrity, and inflammatory responses by modulating growth factor signaling (for example, VEGF, FGF) and by influencing the expression of intracellular inhibitors that tune downstream pathways. In parallel, several papers highlight how MMP family members remodel the extracellular matrix and promote processes such as epithelial–mesenchymal transition, cellular migration, and blood–brain barrier integrity. Collectively, these studies offer important insights into how microRNA‐mediated gene regulation and protease activity collaborate in developmental and pathologic contexts—a theme echoed across studies on vascular repair, immune cell recruitment, and tissue regeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "46"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note, however, that none of these abstracts address the function of RNU2-1. RNU2-1, a small nuclear RNA known primarily for its role in pre‐messenger RNA splicing as part of the spliceosome, is not discussed or functionally characterized in any of the reports summarized above. Thus, while these studies richly elaborate on microRNA‐dependent gene regulation and extracellular protease activity in various pathophysiological settings, they provide no insight into any additional or alternative functions for RNU2-1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "46"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Niina Reunanen, Song-Ping Li, Matti Ahonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M204296200"}], "href": "https://doi.org/10.1074/jbc.M204296200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12060661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12060661"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Erik Maquoi, Diego Demeulemeester, Gabor Vörös, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12669125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12669125"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bryony S Wiseman, Mark D Sternlicht, Leif R Lund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200302090"}], "href": "https://doi.org/10.1083/jcb.200302090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12975354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12975354"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kristen M Clements, Joanne S Price, Mark G Chambers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.11355"}], "href": "https://doi.org/10.1002/art.11355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14673996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14673996"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jochen Reiser, Jun Oh, Isao Shirato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401973200"}], "href": "https://doi.org/10.1074/jbc.M401973200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15197181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15197181"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vandana Iyer, Kevin Pumiglia, C Michael DiPersio "}, {"type": "b", "children": [{"type": "t", "text": "Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01708"}], "href": "https://doi.org/10.1242/jcs.01708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15728252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15728252"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yanyang Zhao, Satsuki Itoh, Xiangchun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608764200"}], "href": "https://doi.org/10.1074/jbc.M608764200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17043354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17043354"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Suzuki, N Nagai, K Umemura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1538-7836.2007.02628.x"}], "href": "https://doi.org/10.1111/j.1538-7836.2007.02628.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17596135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17596135"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Harumi Furochi, Seiko Tamura, Mai Mameoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2007.11.036"}], "href": "https://doi.org/10.1016/j.febslet.2007.11.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18036345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18036345"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rik J U Lories, Jenny Peeters, Astrid Bakker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.23137"}], "href": "https://doi.org/10.1002/art.23137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18050203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18050203"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Takanori Eguchi, Satoshi Kubota, Kazumi Kawata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01288-07"}], "href": "https://doi.org/10.1128/MCB.01288-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18172013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18172013"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dong Hee Choi, Eun-Mee Kim, Hyo Jin Son, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2008.05399.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2008.05399.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18397366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18397366"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Stefan Plantman, Manuel Patarroyo, Kaj Fried, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2008.05.015"}], "href": "https://doi.org/10.1016/j.mcn.2008.05.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18590826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18590826"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shusheng Wang, Arin B Aurora, Brett A Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2008.07.002"}], "href": "https://doi.org/10.1016/j.devcel.2008.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18694565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18694565"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Basam Z Barkho, Ari E Munoz, Xuekun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/stemcells.2008-0519"}], "href": "https://doi.org/10.1634/stemcells.2008-0519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18818437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18818437"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Frank Kuhnert, Michael R Mancuso, Jessica Hampton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.029736"}], "href": "https://doi.org/10.1242/dev.029736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18987025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18987025"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kevin K Kim, Ying Wei, Charles Szekeres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI36940"}], "href": "https://doi.org/10.1172/JCI36940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19104148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19104148"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Coert Margadant, Karine Raymond, Maaike Kreft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.029108"}], "href": "https://doi.org/10.1242/jcs.029108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19118220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19118220"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Coen van Solingen, Leonard Seghers, Roel Bijkerk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2008.00613.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2008.00613.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19120690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19120690"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Amelia Stanco, Charles Szekeres, Nikhil Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0811343106"}], "href": "https://doi.org/10.1073/pnas.0811343106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19383784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19383784"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kara Mitchell, Charles Szekeres, Vincenzo Milano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.040956"}], "href": "https://doi.org/10.1242/jcs.040956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19435806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19435806"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yasuhiro Suzuki, Nobuo Nagai, Kasumi Yamakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-02-203919"}], "href": "https://doi.org/10.1182/blood-2009-02-203919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19608750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19608750"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Joerg Mattes, Adam Collison, Maximilian Plank, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0905063106"}], "href": "https://doi.org/10.1073/pnas.0905063106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19843690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19843690"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Wei Cui, Qingzhang Li, Li Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-0834-1"}], "href": "https://doi.org/10.1007/s11010-011-0834-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21526342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21526342"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jason L Johnson, Amrita Dwivedi, Michelle Somerville, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.111.225623"}], "href": "https://doi.org/10.1161/ATVBAHA.111.225623"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21719762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21719762"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Coen van Solingen, Hetty C de Boer, Roel Bijkerk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvr227"}], "href": "https://doi.org/10.1093/cvr/cvr227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21856785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21856785"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Cory M Yamashita, Lior Dolgonos, Rachel L Zemans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2011.06.041"}], "href": "https://doi.org/10.1016/j.ajpath.2011.06.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21871427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21871427"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Kelsey Roe, Mukesh Kumar, Stephanie Lum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/vir.0.040899-0"}], "href": "https://doi.org/10.1099/vir.0.040899-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22398316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22398316"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "S A Asgeirsdóttir, C van Solingen, N F Kurniati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00400.2011"}], "href": "https://doi.org/10.1152/ajprenal.00400.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22419694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22419694"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Melody L Stallings-Mann, Jens Waldmann, Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3004062"}], "href": "https://doi.org/10.1126/scitranslmed.3004062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22786680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22786680"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Feng Huang, Xiao Zhu, Xin-Qun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal stem cells modified with miR-126 release angiogenic factors and activate Notch ligand Delta-like-4, enhancing ischemic angiogenesis and cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2012.1200"}], "href": "https://doi.org/10.3892/ijmm.2012.1200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23229021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23229021"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Norman Sachs, Pablo Secades, Laura van Hulst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1204614110"}], "href": "https://doi.org/10.1073/pnas.1204614110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23236172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23236172"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Andong Qin, Zhenke Wen, Ya Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-126 regulates the induction and function of CD4(+) Foxp3(+) regulatory T cells through PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.12003"}], "href": "https://doi.org/10.1111/jcmm.12003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23301798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23301798"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yun Zhang, Pengyuan Yang, Tao Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2690"}], "href": "https://doi.org/10.1038/ncb2690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23396050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23396050"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Ran Gao, Yue Yu, Atsushi Inoue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.466136"}], "href": "https://doi.org/10.1074/jbc.M113.466136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23564449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23564449"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Young Cheul Chung, Yoon-Seong Kim, Eugene Bok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2013/370526"}], "href": "https://doi.org/10.1155/2013/370526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23853428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23853428"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Kai Kessenbrock, Gerrit J P Dijkgraaf, Devon A Lawson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2013.06.005"}], "href": "https://doi.org/10.1016/j.stem.2013.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23871604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23871604"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Felix Jansen, Xiaoyan Yang, Marion Hoelscher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.113.001720"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.113.001720"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24014835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24014835"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Judith Agudo, Albert Ruzo, Navpreet Tung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2767"}], "href": "https://doi.org/10.1038/ni.2767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24270517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24270517"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Andreas Schober, Maliheh Nazari-Jahantigh, Yuanyuan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3487"}], "href": "https://doi.org/10.1038/nm.3487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24584117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24584117"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Jee Youn Lee, Hae Young Choi, Hyun-Jong Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2014.07.016"}], "href": "https://doi.org/10.1016/j.ajpath.2014.07.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25325922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25325922"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Zejuan Li, Ping Chen, Rui Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression and knockout of miR-126 both promote leukemogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-04-639062"}], "href": "https://doi.org/10.1182/blood-2015-04-639062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26361793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26361793"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Shruti Rawal, Pujika Emani Munasinghe, Amol Shindikar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvw235"}], "href": "https://doi.org/10.1093/cvr/cvw235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28065883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28065883"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Jeffrey O'Callaghan, Darragh E Crosbie, Paul S Cassidy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx028"}], "href": "https://doi.org/10.1093/hmg/ddx028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28158775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28158775"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Poornima Venkat, Chengcheng Cui, Michael Chopp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-126 Mediates Brain Endothelial Cell Exosome Treatment-Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.119.025371"}], "href": "https://doi.org/10.1161/STROKEAHA.119.025371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31394992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31394992"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Jiaji Pan, Meijie Qu, Yongfang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.119.027531"}], "href": "https://doi.org/10.1161/STROKEAHA.119.027531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31822249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31822249"}]}]}]}