{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of these studies reveals that none of the provided abstracts describe or investigate a direct function for RNU6‐8. Instead, the literature is dominated by extensive analyses of ETS family transcription factors—especially ETS2 (and, in several instances, ETS1)—which are shown to orchestrate diverse aspects of cell behavior during development, differentiation, and disease. While RNU6‐8 (a small nuclear RNA often used as a reference or involved in RNA processing) is not discussed, the body of work emphasizes that ETS factors function as critical regulators of gene expression in multiple biological systems. For example, several reports detail how ETS proteins modulate key downstream target genes to promote endothelial organization during embryonic angiogenesis and trophoblast‐mediated signaling for axis formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther articles in the collection focus on ETS2’s pivotal roles in developmental patterning and cell‐fate determination. In these studies ETS2 is shown to maintain trophoblast stem cell self‐renewal, influence mesoderm and placental formation, and regulate adipocyte as well as muscle gene programs via its transcriptional activity. These functions are often executed by direct binding to promoters (or partnering with other factors such as Prox1) and by integrating signals from pathways such as MAPK/ERK, thereby fine‐tuning the expression of genes required for processes like angiogenesis, lymphangiogenesis, and even embryonic axis establishment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA further subset of these studies elucidates how ETS2 (and its coactivators or repressors) contributes to pathological conditions such as tumor progression, inflammation, and tissue remodeling. In multiple cancer models—including breast, colon, pancreatic, and osteosarcoma—ETS2 activity is linked to changes in the tumor microenvironment, regulation of metastasis‐promoting factors (including oncogenic microRNAs) and proteases, and alterations in immune cell recruitment. Parallel investigations in inflammatory and fibrotic settings demonstrate that ETS2 modulates cytokine and chemokine production (often through interactions with epigenetic modifiers such as HDAC1), thereby influencing IL-6, HO-1, and other mediators of the inflammatory cascade. These studies underscore a recurring theme where ETS2 acts both as a transcriptional activator and repressor to balance cellular proliferation, differentiation and stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "38"}, {"type": "fg_f", "ref": "34"}, {"type": "fg_f", "ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, although RNU6‐8 itself is not characterized within these abstracts, the collective findings illuminate the multifaceted roles of ETS family transcription factors as master regulators in development, homeostasis, and disease. It remains to be determined whether RNU6‐8 plays a complementary or merely a supportive (e.g., reference or processing) role in these cellular contexts. Further work will be needed to clarify any direct regulatory functions of RNU6‐8, especially given the prominence of non‐coding RNAs emerging in other regulatory networks.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "N Mucci, A Ianni, C L Ursini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo modulation of ETS genes induced by electromagnetic fields."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vivo (2001)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11887334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11887334"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Arnaud Zaldumbide, Françoise Carlotti, Philippe Pognonec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of the Ets2 transcription factor in the proliferation, maturation, and survival of mouse thymocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.9.4873"}], "href": "https://doi.org/10.4049/jimmunol.169.9.4873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12391198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12391198"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alban de Kerchove D'Exaerde, Jean Cartaud, Aymeric Ravel-Chapuis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/embo-reports/kvf220"}], "href": "https://doi.org/10.1093/embo-reports/kvf220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393756"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kimberly M Baker, Guo Wei, Alicia Erbe Schaffner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M209480200"}], "href": "https://doi.org/10.1074/jbc.M209480200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12637547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12637547"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Albert K Man, Lawrence J T Young, John A Tynan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2-dependent stromal regulation of mouse mammary tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.23.8614-8625.2003"}], "href": "https://doi.org/10.1128/MCB.23.23.8614-8625.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14612405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14612405"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Su Wol Chung, Yen-Hsu Chen, Mark A Perrella "}, {"type": "b", "children": [{"type": "t", "text": "Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409125200"}], "href": "https://doi.org/10.1074/jbc.M409125200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15590657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15590657"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "John A Tynan, Fang Wen, William J Muller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2-dependent microenvironmental support of mouse mammary tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208856"}], "href": "https://doi.org/10.1038/sj.onc.1208856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16007139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16007139"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pantelis Georgiades, Janet Rossant "}, {"type": "b", "children": [{"type": "t", "text": "Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02277"}], "href": "https://doi.org/10.1242/dev.02277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16481355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16481355"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Luigi Bagella, Cristina Giacinti, Cristiano Simone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.20981"}], "href": "https://doi.org/10.1002/jcb.20981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16741970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16741970"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sarantis Polychronopoulos, Mihalis Verykokakis, Mustafa N Yazicioglu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605185200"}], "href": "https://doi.org/10.1074/jbc.M605185200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16799155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16799155"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Fang Wen, John A Tynan, Grace Cecena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2 is required for trophoblast stem cell self-renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2007.09.024"}], "href": "https://doi.org/10.1016/j.ydbio.2007.09.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17977525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17977525"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "G De la Houssaye, V Vieira, C Masson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18958307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18958307"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shu Wang, Yuhui Yuan, Lan Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0808703105"}], "href": "https://doi.org/10.1073/pnas.0808703105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19109434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19109434"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Monika J Stankiewicz, John D Crispino "}, {"type": "b", "children": [{"type": "t", "text": "ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-08-174813"}], "href": "https://doi.org/10.1182/blood-2008-08-174813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19168790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19168790"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Junghee Lee, Mari Kannagi, Robert J Ferrante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-121046"}], "href": "https://doi.org/10.1096/fj.08-121046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19179380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19179380"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guo Wei, Ruchika Srinivasan, Carmen Z Cantemir-Stone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-03-211391"}], "href": "https://doi.org/10.1182/blood-2009-03-211391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19411629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19411629"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Cheryl A Hill, Thomas E Sussan, Roger H Reeves, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic \"Down syndrome\" mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.33012"}], "href": "https://doi.org/10.1002/ajmg.a.33012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19764029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19764029"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "C Odiatis, P Georgiades "}, {"type": "b", "children": [{"type": "t", "text": "New insights for Ets2 function in trophoblast using lentivirus-mediated gene knockdown in trophoblast stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2010.05.001"}], "href": "https://doi.org/10.1016/j.placenta.2010.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20569982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20569982"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jorge Múnera, Grace Ceceña, Paul Jedlicka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2 regulates colonic stem cells and sensitivity to tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.599"}], "href": "https://doi.org/10.1002/stem.599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21425406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21425406"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Caroline Cheng, Dennie Tempel, Wijnand K Den Dekker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.111.243444"}], "href": "https://doi.org/10.1161/CIRCRESAHA.111.243444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21700929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21700929"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yasuhiro Yoshimatsu, Tomoko Yamazaki, Hajime Mihira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.083998"}], "href": "https://doi.org/10.1242/jcs.083998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21807940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21807940"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Kivanç Birsoy, Ryan Berry, Tim Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.067710"}], "href": "https://doi.org/10.1242/dev.067710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21989915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21989915"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Eun-Ju Park, Mi-Jin Kim, Wan Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets-2 is involved in transcriptional regulation of C1qTNF-related protein 5 in muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-012-1809-3"}], "href": "https://doi.org/10.1007/s11033-012-1809-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22740135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22740135"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Christiana Polydorou, Pantelis Georgiades "}, {"type": "b", "children": [{"type": "t", "text": "Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2646"}], "href": "https://doi.org/10.1038/ncomms2646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23552073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23552073"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Julie A Wallace, Fu Li, Subhasree Balakrishnan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0071533"}], "href": "https://doi.org/10.1371/journal.pone.0071533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23977064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23977064"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Shinu John, Lisa Russell, Shu Shien Chin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00612-13"}], "href": "https://doi.org/10.1128/MCB.00612-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24277931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24277931"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Susan R Quinn, Niamh E Mangan, Brian E Caffrey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.522730"}], "href": "https://doi.org/10.1074/jbc.M113.522730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24362029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24362029"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Mohamed Kabbout, Duaa Dakhlallah, Sudarshana Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0100693"}], "href": "https://doi.org/10.1371/journal.pone.0100693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24968297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24968297"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Martyn Donnison, Ric Broadhurst, Peter L Pfeffer "}, {"type": "b", "children": [{"type": "t", "text": "Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2014.10.011"}], "href": "https://doi.org/10.1016/j.ydbio.2014.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25446535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25446535"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jason R Pitarresi, Xin Liu, Sudarshana M Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2016.07.006"}], "href": "https://doi.org/10.1016/j.neo.2016.07.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27659014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27659014"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Elena Vorgia, Andreas Zaragkoulias, Ioanna Peraki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of Fgf2 by ETS2 repressor factor (ERF) is required for chorionic trophoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.22780"}], "href": "https://doi.org/10.1002/mrd.22780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28244611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28244611"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Rasoul Pourebrahim, Yun Zhang, Bin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.304972.117"}], "href": "https://doi.org/10.1101/gad.304972.117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29021240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29021240"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xianwei Ma, Zhengyu Jiang, Na Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102480"}], "href": "https://doi.org/10.18632/aging.102480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31785145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31785145"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Jun Zhao, Kai Huang, Hui-Zhong Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.11.123"}], "href": "https://doi.org/10.1016/j.bbrc.2019.11.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31810605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31810605"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Sarang Tartey, Prajwal Gurung, Rajendra Karki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41423-020-0398-7"}], "href": "https://doi.org/10.1038/s41423-020-0398-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32203187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32203187"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yuxuan Luo, Nan Jiang, Herman I May, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.120.052384"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.120.052384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33821668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33821668"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Lulu He, Qun Cai, Xi Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Virol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jmv.28710"}], "href": "https://doi.org/10.1002/jmv.28710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36975761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36975761"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Shuxiang Chen, Xiaotong Zhu, Wenhuan Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2023.194965"}], "href": "https://doi.org/10.1016/j.bbagrm.2023.194965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37524226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37524226"}]}]}]}