RPGRIP1 Gene

HGNC Family	C2 domain containing
Name	retinitis pigmentosa GTPase regulator interacting protein 1
Description	This gene encodes a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. Mutations in this gene lead to autosomal recessive congenital blindness. [provided by RefSeq, Oct 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRPGRIP1 is a multifunctional ciliary protein that plays a crucial role in photoreceptor integrity by serving as a scaffold and directing the proper assembly of protein complexes at key subcellular locations. Early studies demonstrated that RPGRIP1 localizes to the outer segments and connecting cilium of both rod and cone photoreceptors, where it interacts directly with RPGR and with centrosomal partners at basal bodies and centrioles. These localizations, observed in both human and bovine models, underline its importance in maintaining the structure and function of the photoreceptor cilium."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDetailed structural analyses have revealed that specific domains of RPGRIP1—especially its dual C2 domains—mediate critical interactions with other ciliary proteins. For instance, the C2 domains are implicated in potential Ca2⁺ binding and are essential for binding nephrocystin-4 (NPHP4), a partnership that has been shown to be disrupted by missense mutations found in patients with Leber congenital amaurosis (LCA) and Senior–Løken syndrome. Moreover, studies indicate that the conserved RPGR-interacting domain of RPGRIP1 is subject to differential proteolytic cleavage, leading to a stable N-terminal fragment that accumulates in the nucleus, suggesting distinct subcellular-specific functions and a novel nucleocytoplasmic communication pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its direct interactions with RPGR and NPHP4, RPGRIP1 is critical for maintaining the architecture of the photoreceptor connecting cilium and ensuring the fidelity of protein trafficking between the inner and outer segments. Disruption of these functions—whether through loss-of-function or gain-of-function mutations—leads to severe defects in ciliary organization and transport, which underlies the pathogenesis of retinal dystrophies. Furthermore, emerging data have linked RPGRIP1 to broader ciliopathy networks; it functions in concert with its homolog RPGRIP1L and other transition zone components to secure proper cilium assembly and stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther clinical and experimental investigations have underscored the importance of RPGRIP1’s structural role in photoreceptors. Mutations that lead to the loss of the RPGR-interacting region and the subsequent mislocalization of RPGRIP1 are consistently associated with early-onset retinal dystrophies such as LCA and cone–rod dystrophy. Such mutations impair the formation and stability of the ciliary protein complex at the connecting cilium, thereby disrupting normal photoreceptor protein trafficking. Similar findings were reported in diverse patient cohorts, where even isolated cone dysfunction has been attributed to RPGRIP1 variants."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary genetic studies in larger cohorts have expanded the mutational spectrum of RPGRIP1 and confirmed its pivotal function in retinal health. Notably, analyses of patients with both nonsyndromic LCA and retinitis pigmentosa have revealed novel mutations that reinforce the essential role of RPGRIP1 in the maintenance and function of photoreceptors, while deep intronic mutations further highlight the importance of proper gene splicing in generating a functional protein. These insights underscore the therapeutic potential aimed at restoring or modulating RPGRIP1 function in retinal degenerative diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Timur A Mavlyutov, Haiyan Zhao, Paulo A Ferreira "}, {"type": "b", "children": [{"type": "t", "text": "Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/11.16.1899"}], "href": "https://doi.org/10.1093/hmg/11.16.1899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12140192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12140192"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X Shu, A M Fry, B Tulloch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi129"}], "href": "https://doi.org/10.1093/hmg/ddi129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15772089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15772089"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinrong Lu, Mallikarjuna Guruju, John Oswald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi143"}], "href": "https://doi.org/10.1093/hmg/ddi143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15800011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15800011"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ronald Roepman, Stef J F Letteboer, Heleen H Arts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0505774102"}], "href": "https://doi.org/10.1073/pnas.0505774102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16339905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16339905"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carlos A Murga-Zamalloa, Anand Swaroop, Hemant Khanna "}, {"type": "b", "children": [{"type": "t", "text": "RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12041-009-0061-7"}], "href": "https://doi.org/10.1007/s12041-009-0061-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20090203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20090203"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lorena Fernández-Martínez, Stef Letteboer, Christian Y Mardin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2010.217"}], "href": "https://doi.org/10.1038/ejhg.2010.217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224891"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Karlien L M Coene, Dorus A Mans, Karsten Boldt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr280"}], "href": "https://doi.org/10.1093/hmg/ddr280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21685204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21685204"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Malika Fakhratova "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel LCA6 mutation in an Emirati family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/13816810.2012.755552"}], "href": "https://doi.org/10.3109/13816810.2012.755552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23278760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23278760"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Arif O Khan, Leen Abu-Safieh, Tobias Eisenberger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RPGRIP1-related retinal phenotype in children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Ophthalmol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/bjophthalmol-2012-303050"}], "href": "https://doi.org/10.1136/bjophthalmol-2012-303050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23505306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23505306"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Arif O Khan, Saleh Al-Mesfer, Shahira Al-Turkmani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of strictly defined Leber congenital amaurosis with (and without) neurodevelopmental delay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Ophthalmol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/bjophthalmol-2014-305122"}], "href": "https://doi.org/10.1136/bjophthalmol-2014-305122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24997176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24997176"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Takahide Suzuki, Takuro Fujimaki, Ai Yanagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel exon 17 deletion mutation of RPGRIP1 gene in two siblings with Leber congenital amaurosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Jpn J Ophthalmol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10384-014-0339-z"}], "href": "https://doi.org/10.1007/s10384-014-0339-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25096270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25096270"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Aiden Eblimit, Thanh-Minh T Nguyen, Yiyun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu573"}], "href": "https://doi.org/10.1093/hmg/ddu573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25398945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25398945"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hui Huang, Ying Wang, Huishuang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted next generation sequencing identified novel mutations in RPGRIP1 associated with both retinitis pigmentosa and Leber's congenital amaurosis in unrelated Chinese patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.17052"}], "href": "https://doi.org/10.18632/oncotarget.17052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28456785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28456785"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Saber Imani, Jingliang Cheng, Abdolkarim Mobasher-Jannat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel RPGRIP1 mutation in an Iranian family with leber congenital amaurosis by exome sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13454"}], "href": "https://doi.org/10.1111/jcmm.13454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29193763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29193763"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Antonia Wiegering, Renate Dildrop, Lisa Kalfhues, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell type-specific regulation of ciliary transition zone assembly in vertebrates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201797791"}], "href": "https://doi.org/10.15252/embj.201797791"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29650680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29650680"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Luyao Zhu, Wangbin Ouyang, Minfang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular genetics with clinical characteristics of Leber congenital amaurosis in the Han population of western China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2021.1904417"}], "href": "https://doi.org/10.1080/13816810.2021.1904417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33970760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33970760"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Arif O Khan "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RPGRIP1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-related retinal disease presenting as isolated cone dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2023.2175224"}], "href": "https://doi.org/10.1080/13816810.2023.2175224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36762997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36762997"}]}]}]}
Synonyms	RGRIP, RGI1, CORD13, RPGRIP1D, RPGRIP, LCA6
Proteins	RPGR1_HUMAN
NCBI Gene ID	57096
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPGRIP1 has 4,487 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for RPGRIP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPGRIP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RPGRIP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPGRIP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPGRIP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RPGRIP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RPGRIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPGRIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPGRIP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RPGRIP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPGRIP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPGRIP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RPGRIP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPGRIP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RPGRIP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RPGRIP1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RPGRIP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPGRIP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPGRIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPGRIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RPGRIP1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RPGRIP1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RPGRIP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPGRIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RPGRIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPGRIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPGRIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPGRIP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPGRIP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RPGRIP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RPGRIP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RPGRIP1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RPGRIP1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPGRIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPGRIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RPGRIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RPGRIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RPGRIP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPGRIP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RPGRIP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RPGRIP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RPGRIP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.