| Name | RPL17-C18orf32 readthrough |
| Description | This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the downstream gene exons. [provided by RefSeq, Dec 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRPL17‑C18orf32, which encodes a protein also known as DCAF1 or VprBP, functions as a substrate receptor within the multisubunit CRL4 (cullin‑RING E3 ubiquitin ligase) complex. This complex orchestrates the proteasomal degradation of proteins critical for maintaining cell homeostasis. For example, in female germ cells, CRL4(VPRBP) activates TET methylcytosine dioxygenases that are central to oocyte gene expression, follicle maintenance, and genome reprogramming during fertilization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system, RPL17‑C18orf32 is indispensable for proper T‑ and B‑cell function. Upon antigen receptor activation, its expression is upregulated to support T‑cell growth, cell cycle entry, and proliferation in part through regulating p53 degradation. Moreover, by associating with components involved in V(D)J recombination—linking with RAG1 and ensuring timely turnover of RAG1 via ubiquitin‑dependent mechanisms—this factor helps limit error‑prone repair and facilitates appropriate receptor editing. Its deficiency leads to impaired immune cell expansion, premature T‑cell senescence with elevated reactive oxygen species, and defective B‑cell receptor editing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, RPL17‑C18orf32 modulates key developmental signaling cascades. It interacts with inhibitory Smads and Smurf E3 ubiquitin ligases to promote the ubiquitination and proteasomal degradation of the TGF‑β type I receptor, thereby attenuating TGF‑β/Activin signaling. This negative regulation is critical for fine‑tuning mesoderm induction and embryonic stem cell differentiation. In this way, RPL17‑C18orf32 serves as a regulatory nexus linking ubiquitin‑mediated protein turnover with signal transduction and cellular differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chao Yu, Yin-Li Zhang, Wei-Wei Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1244587"}], "href": "https://doi.org/10.1126/science.1244587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24357321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24357321"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zengli Guo, Gang Wang, Bing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DCAF1 regulates Treg senescence via the ROS axis during immunological aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI136466"}], "href": "https://doi.org/10.1172/JCI136466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32730228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32730228"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chad M McCall, Paula L Miliani de Marval, Paul D Chastain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00232-08"}], "href": "https://doi.org/10.1128/MCB.00232-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18606781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18606781"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michele D Kassmeier, Koushik Mondal, Victoria L Palmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.455"}], "href": "https://doi.org/10.1038/emboj.2011.455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22157821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22157821"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zengli Guo, Qing Kong, Cui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DCAF1 controls T-cell function via p53-dependent and -independent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10307"}], "href": "https://doi.org/10.1038/ncomms10307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26728942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26728942"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "N Max Schabla, Greg A Perry, Victoria L Palmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1800054"}], "href": "https://doi.org/10.4049/jimmunol.1800054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29925675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29925675"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yihao Li, Chao Cui, Feng Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjz057"}], "href": "https://doi.org/10.1093/jmcb/mjz057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31291647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31291647"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Victoria L Palmer, Razia Aziz-Seible, Michele D Kassmeier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1500952"}], "href": "https://doi.org/10.4049/jimmunol.1500952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26150531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26150531"}]}]}]}
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| Synonyms | RPL17-C18orf32 |
| NCBI Gene ID | 100526842 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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RPL17-C18ORF32 has 3,670 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 39 datasets.
Click the + buttons to view associations for RPL17-C18ORF32 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of RPL17-C18ORF32 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing RPL17-C18ORF32 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with RPL17-C18ORF32 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of RPL17-C18ORF32 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RPL17-C18ORF32 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with RPL17-C18ORF32 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with RPL17-C18ORF32 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RPL17-C18ORF32 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPL17-C18ORF32 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of RPL17-C18ORF32 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RPL17-C18ORF32 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving RPL17-C18ORF32 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing RPL17-C18ORF32 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of RPL17-C18ORF32 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of RPL17-C18ORF32 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RPL17-C18ORF32 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with RPL17-C18ORF32 gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with RPL17-C18ORF32 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of RPL17-C18ORF32 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of RPL17-C18ORF32 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of RPL17-C18ORF32 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of RPL17-C18ORF32 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of RPL17-C18ORF32 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving RPL17-C18ORF32 protein from the Wikipathways PFOCR 2024 dataset. | |
| ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of RPL17-C18ORF32 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of RPL17-C18ORF32 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of RPL17-C18ORF32 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of RPL17-C18ORF32 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RPL17-C18ORF32 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RPL17-C18ORF32 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RPL17-C18ORF32 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of RPL17-C18ORF32 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of RPL17-C18ORF32 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RPL17-C18ORF32 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RPL17-C18ORF32 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with RPL17-C18ORF32 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| Virus MINT Protein-Viral Protein Interactions | interacting viral proteins for RPL17-C18ORF32 from the Virus MINT Protein-Viral Protein Interactions dataset. | |
| Virus MINT Protein-Virus Interactions | viruses interacting with RPL17-C18ORF32 from the Virus MINT Protein-Virus Interactions dataset. | |
| WikiPathways Pathways 2014 | pathways involving RPL17-C18ORF32 protein from the Wikipathways Pathways 2014 dataset. | |
