RPRD1B Gene

Name	regulation of nuclear pre-mRNA domain containing 1B
Description	Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in several processes, including RNA polymerase II promoter clearance; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRPRD1B (also known as CREPT) is an oncogenic transcriptional regulator that is overexpressed in a variety of human tumors. In several studies, its elevated expression was linked to enhanced transcription of key cell‐cycle regulators—most notably Cyclin D1—through direct promoter binding and facilitation of chromatin looping. This activity helps to accelerate tumor cell proliferation and is associated with advanced tumor stage and poor prognosis in cancers such as endometrial and non‐small‐cell lung carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, RPRD1B functions as a scaffold that directly interacts with the C-terminal domain (CTD) of RNA polymerase II. It forms homo- and heterodimers (with the structurally related RPRD1A) through conserved coiled-coil domains and preferentially binds CTD repeats phosphorylated at specific serine residues (S2 and S7). This interaction recruits the RPAP2 phosphatase, thereby coordinating dephosphorylation of the S5 residue during transcription initiation and elongation. In addition, RPRD1B engages with signaling molecules such as β-catenin and TCF4, enhancing their association and binding to target gene promoters to promote Wnt/β-catenin–dependent gene transcription."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in transcriptional regulation, RPRD1B plays a critical part in cell cycle progression by modulating the expression of additional cyclins. In gastric cancer cells, for example, RPRD1B interacts with Aurora kinase B, which phosphorylates it at serine 145—a modification required for the transcriptional upregulation of Cyclin B1 and the promotion of G2/M transition. Such mechanistic insights further explain how RPRD1B overexpression drives tumorigenesis in diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dongdong Lu, Yinyuan Wu, Yinyin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2011.12.016"}], "href": "https://doi.org/10.1016/j.ccr.2011.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22264791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22264791"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuan Wang, Haifeng Qiu, Weixu Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.2990"}], "href": "https://doi.org/10.3892/or.2014.2990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24452636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24452636"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jian Li, Amber R Smith, Rebecca T Marquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22866"}], "href": "https://doi.org/10.1002/mc.22866"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29938829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29938829"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanquan Zhang, Chunxiao Liu, Xiaolin Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the β-catenin·TCF4 transcriptional activity in response to Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.560979"}], "href": "https://doi.org/10.1074/jbc.M114.560979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24982424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24982424"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zuyao Ni, Chao Xu, Xinghua Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2853"}], "href": "https://doi.org/10.1038/nsmb.2853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24997600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24997600"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ibraheem Ali, Diego Garrido Ruiz, Zuyao Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2019.04.008"}], "href": "https://doi.org/10.1016/j.molcel.2019.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31054975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31054975"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yanquan Zhang, Shiyan Wang, Wei Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0161-z"}], "href": "https://doi.org/10.1038/s41388-018-0161-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29563608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29563608"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lidan Ding, Liu Yang, Yuqi He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-1211-8"}], "href": "https://doi.org/10.1038/s41419-018-1211-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30518842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30518842"}]}]}]}
Synonyms	CREPT, C20ORF77, Kub5-Hera, NET60, K-H, DJ1057B20.2
Proteins	RPR1B_HUMAN
NCBI Gene ID	58490
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPRD1B has 5,814 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for RPRD1B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPRD1B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPRD1B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPRD1B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RPRD1B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RPRD1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPRD1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPRD1B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPRD1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPRD1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPRD1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RPRD1B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RPRD1B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RPRD1B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPRD1B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPRD1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPRD1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RPRD1B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPRD1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RPRD1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPRD1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPRD1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPRD1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPRD1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RPRD1B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RPRD1B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RPRD1B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RPRD1B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPRD1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPRD1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RPRD1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RPRD1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RPRD1B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPRD1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RPRD1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RPRD1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RPRD1B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RPRD1B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RPRD1B from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RPRD1B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of RPRD1B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of RPRD1B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.