RPS6KA3 Gene

HGNC Family	X-linked mental retardation
Name	ribosomal protein S6 kinase, 90kDa, polypeptide 3
Description	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRSK2, the protein product of the RPS6KA3 gene, is a pivotal serine/threonine kinase operating downstream of the Ras/ERK signaling cascade. By phosphorylating a diverse array of substrates—including transcription factors such as STAT3, NFAT3, CREB, and ELK family members—RSK2 integrates mitogenic signals to modulate gene expression programs that control cell cycle progression, proliferation, and differentiation. Its critical regulatory role is underscored by the observation that loss‐of‐function mutations in RPS6KA3 underlie Coffin–Lowry syndrome, which manifests as cognitive impairment and skeletal abnormalities, while its activity is also indispensable for proper skeletal muscle differentiation and other developmental processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its developmental and proliferative roles, RSK2 enhances cell survival and supports oncogenic transformation by phosphorylating key pro‐apoptotic targets such as Bim_EL and caspase‑8. These phosphorylation events facilitate the degradation or inactivation of these apoptotic mediators, thereby blunting programmed cell death and enabling adaptive responses to cellular stress—and even modulating stress granule dynamics as part of the broader innate immune response. Such actions not only promote tumor cell survival under adverse conditions but also contribute to the overall transformation process."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRSK2 further drives tumor progression by promoting cell motility, invasion, and metastasis through orchestrated reorganization of the cytoskeleton and modulation of cell–matrix adhesion. Its kinase activity stimulates epithelial–mesenchymal transition and activates pro‐migratory transcriptional programs by phosphorylating effectors involved in cytoskeletal remodeling and cell adhesion—including regulators such as FRA1, CREB, EphA2, and stathmin. These modifications lead to enhanced integrin deregulation, altered focal adhesion dynamics, and increased formation of filopodia, which together facilitate the dissemination of malignant cells across diverse tumor types. In this context, pharmacologic targeting of RSK2—using small‐molecule inhibitors like isobavachalcone—has shown promise in reducing tumor cell invasiveness and overcoming chemoresistance, thereby highlighting the therapeutic potential of RSK2‐targeted approaches in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria Zeniou, Solange Pannetier, Jean-Pierre Fryns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unusual splice-site mutations in the RSK2 gene and suggestion of genetic heterogeneity in Coffin-Lowry syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/340607"}], "href": "https://doi.org/10.1086/340607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11992250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11992250"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jason A Lehman, Julian Gomez-Cambronero "}, {"type": "b", "children": [{"type": "t", "text": "Molecular crosstalk between p70S6k and MAPK cell signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0006-291X(02)00238-3"}], "href": "https://doi.org/10.1016/S0006-291X(02"}, {"type": "t", "text": "00238-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12054624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12054624"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yiguo Zhang, Yong-Yeon Cho, Brandon L Petersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210368200"}], "href": "https://doi.org/10.1074/jbc.M210368200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12562765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12562765"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hema Vaidyanathan, Joe W Ramos "}, {"type": "b", "children": [{"type": "t", "text": "RSK2 activity is regulated by its interaction with PEA-15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M303988200"}], "href": "https://doi.org/10.1074/jbc.M303988200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12796492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12796492"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "D E Clark, T M Errington, J A Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-04-3151"}], "href": "https://doi.org/10.1158/0008-5472.CAN-04-3151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15833840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15833840"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "J P Delaunoy, A Dubos, P Marques Pereira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel mutations in the RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-0004.2006.00660.x"}], "href": "https://doi.org/10.1111/j.1399-0004.2006.00660.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16879200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16879200"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yong-Yeon Cho, Ke Yao, Ann M Bode, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RSK2 mediates muscle cell differentiation through regulation of NFAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M611322200"}], "href": "https://doi.org/10.1074/jbc.M611322200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17213202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17213202"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jian-Xin Lin, Rosanne Spolski, Warren J Leonard "}, {"type": "b", "children": [{"type": "t", "text": "Critical role for Rsk2 in T-lymphocyte activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-02-072207"}], "href": "https://doi.org/10.1182/blood-2007-02-072207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17938253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17938253"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sumin Kang, Shaozhong Dong, Ailan Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709673200"}], "href": "https://doi.org/10.1074/jbc.M709673200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18156174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18156174"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Audrey Carrière, Marie Cargnello, Louis-André Julien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2008.07.078"}], "href": "https://doi.org/10.1016/j.cub.2008.07.078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18722121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18722121"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "T S Karin Eisinger-Mathason, Josefa Andrade, Angela L Groehler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.06.025"}], "href": "https://doi.org/10.1016/j.molcel.2008.06.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18775331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18775331"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Elinor Dehan, Florian Bassermann, Daniele Guardavaccaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.12.020"}], "href": "https://doi.org/10.1016/j.molcel.2008.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19150432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19150432"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cong Peng, Yong-Yeon Cho, Feng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.09-151290"}], "href": "https://doi.org/10.1096/fj.09-151290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20385620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20385620"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "John Karijolich, Yang Zhao, Bret Peterson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaposi's sarcoma-associated herpesvirus ORF45 mediates transcriptional activation of the HIV-1 long terminal repeat via RSK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00931-14"}], "href": "https://doi.org/10.1128/JVI.00931-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24719417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24719417"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "G N Alesi, L Jin, D Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.79"}], "href": "https://doi.org/10.1038/onc.2016.79"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27041561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27041561"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "M-A Hospital, A Jacquel, F Mazed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2017.284"}], "href": "https://doi.org/10.1038/leu.2017.284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28914261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28914261"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Binbin Li, Nansong Xu, Zheng Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7090"}], "href": "https://doi.org/10.3892/or.2019.7090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30942462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30942462"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Sun-Mi Yoo, Cheol-Jung Lee, Hyun-Jung An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20081994"}], "href": "https://doi.org/10.3390/ijms20081994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31018569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31018569"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Lo-Kong Chan, Daniel Wai-Hung Ho, Charles Shing Kam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2020.08.036"}], "href": "https://doi.org/10.1016/j.jhep.2020.08.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32918955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32918955"}]}]}]}
Synonyms	ISPK-1, MRX19, HU-3, S6K-ALPHA3, PP90RSK2, RSK2, P90-RSK2, CLS, MAPKAPK1B
Proteins	KS6A3_HUMAN
NCBI Gene ID	6197
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPS6KA3 has 11,809 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 143 datasets.

Click the + buttons to view associations for RPS6KA3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPS6KA3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RPS6KA3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS6KA3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS6KA3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RPS6KA3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RPS6KA3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPS6KA3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS6KA3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving RPS6KA3 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS6KA3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPS6KA3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RPS6KA3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS6KA3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS6KA3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RPS6KA3 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RPS6KA3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RPS6KA3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS6KA3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPS6KA3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPS6KA3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RPS6KA3 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RPS6KA3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RPS6KA3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RPS6KA3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPS6KA3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RPS6KA3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RPS6KA3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPS6KA3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPS6KA3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RPS6KA3 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS6KA3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPS6KA3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RPS6KA3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RPS6KA3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RPS6KA3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RPS6KA3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate RPS6KA3 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RPS6KA3 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RPS6KA3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPS6KA3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPS6KA3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.