RPS6KB2 Gene

Name	ribosomal protein S6 kinase, 70kDa, polypeptide 2
Description	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRPS6KB2, also known as p70 S6 kinase β or S6K2, is a key downstream effector of the mTOR signaling cascade that regulates protein synthesis, cell growth, and nuclear events. Unlike its homolog S6K1, S6K2 displays unique subcellular localization and regulatory mechanisms—including phosphorylation within its nuclear localization signal by protein kinase C—to control its distribution and participate in distinct nuclear functions such as RNA splicing and transcription regulation. Its activity is maintained throughout the cell cycle with particularly high levels in the G2 and M phases, suggesting specialized roles in cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, S6K2 plays multifaceted roles that contribute to tumorigenic processes and treatment responses. Its gene amplification and overexpression have been linked to breast and other cancers, where increased S6K2 levels correlate with estrogen receptor positivity, cyclin D1 (CCND1) amplification, and prognostic implications. Functional studies demonstrate that S6K2 supports cancer cell survival by promoting Akt phosphorylation and upregulating anti‐apoptotic proteins such as Mcl‑1, Bcl‑XL, and XIAP, whereas its suppression can enhance apoptotic responses and diminish metastasis in non–small-cell lung cancer and other tumor models. These findings underscore the potential of S6K2 as both a prognostic biomarker and a therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical role in translational control and cell survival, S6K2 is emerging as an important regulator of additional cellular processes. Its interactome is distinct from that of S6K1, being associated with proteins involved in transcription, splicing, and ribosome biogenesis. Moreover, S6K2 can be modulated by noncoding RNAs—as shown by its interaction with a GLI1‐derived circular RNA that enhances metastasis in melanoma—while factors such as NSUN6 have been found to regulate its function in glioblastoma therapy. Structural elements like a conserved polyproline region further refine its protein–protein interactions, particularly with ribosomal proteins, underscoring its role in fine-tuning translation. Collectively, these studies position RPS6KB2 as a vital integrator of growth factor and stress signals with significant implications for cell cycle regulation and cancer therapy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Taras Valovka, Frederique Verdier, Rainer Cramer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.3.852-863.2003"}], "href": "https://doi.org/10.1128/MCB.23.3.852-863.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12529391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12529391"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Derek Boyer, Rene Quintanilla, Kay K Lee-Fruman "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of catalytic activity of S6 kinase 2 during cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-007-9584-5"}], "href": "https://doi.org/10.1007/s11010-007-9584-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17786541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17786541"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eddy T H Goh, Olivier E Pardo, Nicholas Michael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.078782"}], "href": "https://doi.org/10.1074/jbc.M109.078782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20308064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20308064"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tim R Fenton, Ivan T Gout "}, {"type": "b", "children": [{"type": "t", "text": "Functions and regulation of the 70kDa ribosomal S6 kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2010.09.018"}], "href": "https://doi.org/10.1016/j.biocel.2010.09.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20932932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20932932"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gizeh Pérez-Tenorio, Elin Karlsson, Marie Ahnström Waltersson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-010-1058-x"}], "href": "https://doi.org/10.1007/s10549-010-1058-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20953835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20953835"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Martha L Slattery, Abbie Lundgreen, Jennifer S Herrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutat Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mrfmmm.2010.10.005"}], "href": "https://doi.org/10.1016/j.mrfmmm.2010.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21035469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21035469"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Savitha Sridharan, Alakananda Basu "}, {"type": "b", "children": [{"type": "t", "text": "S6 kinase 2 promotes breast cancer cell survival via Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-3253"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-3253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21427355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21427355"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Caterina Nardella, Andrea Lunardi, Giuseppe Fedele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-3962"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-3962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21444676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21444676"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "T Yu, J Li, M Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.574"}], "href": "https://doi.org/10.1038/onc.2013.574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24469061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24469061"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Matthew J Warner, Katherine S Bridge, James P Hewitson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw631"}], "href": "https://doi.org/10.1093/nar/gkw631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27407113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27407113"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alakananda Basu, Savitha Sridharan "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0173854"}], "href": "https://doi.org/10.1371/journal.pone.0173854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28301598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28301598"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nurettin İlter Sever, Sevilay Cengiz Şahin "}, {"type": "b", "children": [{"type": "t", "text": "S6K2 promises an important therapeutic potential for cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2018-0332"}], "href": "https://doi.org/10.2217/fon-2018-0332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30730779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30730779"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Qiang Ma, Yipin Yang, Shuwen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal protein S6 kinase 2 (RPS6KB2) is a potential immunotherapeutic target for cancer that upregulates proinflammatory cytokines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-023-09134-5"}], "href": "https://doi.org/10.1007/s11033-023-09134-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38281249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38281249"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Isadora C B Pavan, Sami Yokoo, Daniela C Granato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.201500249"}], "href": "https://doi.org/10.1002/pmic.201500249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27493124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27493124"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Leticia Meneguello, Natália M Barbosa, Karina D Pereira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27888"}], "href": "https://doi.org/10.1002/jcb.27888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30320934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30320934"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jun Chen, Xiaobo Zhou, Jie Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02799-x"}], "href": "https://doi.org/10.1038/s41419-020-02799-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32732916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32732916"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chidiebere U Awah, Jan Winter, Claudiane M Mazdoom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2021.1990631"}], "href": "https://doi.org/10.1080/15384047.2021.1990631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34705606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34705606"}]}]}]}
Synonyms	S6Kbeta, KLS, P70-BETA, P70S6KB, S6KI(2), P70-BETA-2, STK14B, S6KB, S6K2, P70-BETA-1, P70(S6K)-BETA, S6K-BETA2, SRK
Proteins	KS6B2_HUMAN
NCBI Gene ID	6199
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPS6KB2 has 8,487 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for RPS6KB2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPS6KB2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS6KB2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS6KB2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RPS6KB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RPS6KB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPS6KB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS6KB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS6KB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPS6KB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RPS6KB2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS6KB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS6KB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RPS6KB2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RPS6KB2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS6KB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPS6KB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPS6KB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RPS6KB2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RPS6KB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPS6KB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RPS6KB2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RPS6KB2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPS6KB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPS6KB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS6KB2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPS6KB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RPS6KB2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RPS6KB2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RPS6KB2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RPS6KB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPS6KB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPS6KB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RPS6KB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RPS6KB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RPS6KB2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS6KB2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RPS6KB2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RPS6KB2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RPS6KB2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RPS6KB2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS6KB2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.