RSPH10B2 Gene

Name radial spoke head 10 homolog B2 (Chlamydomonas)
Description This gene encodes a protein component of the radial spoke head in flagella and motile cilia. Eukaryotic flagella and motile cilia share a common 9 + 2 structure, in which nine peripheral microtubule doublets (MTDs) surround a central-pair of microtubules (CP), with radial spokes connecting the MTDs to the CP. The radial spoke is a multi-protein complex that works as a mechanochemical transducer between the CP and the MTDs. The radial spoke contributes to the regulation of the activity of dynein motors, and thus to flagellar motility. PMID: 22754630 provides a good review of radial spokes. [provided by RefSeq, Jul 2017]
Summary
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These studies emphasize how altered PKA activity (by haploinsufficiency or mutation of PRKAR1A) perturbs normal cell signaling pathways, leading to diverse phenotypes including endocrine neoplasias, cardiac, skeletal, and neural abnormalities."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "25"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that despite the extensive focus on PKA signaling and the myriad of cellular functions affected by its dysregulation, none of these abstracts provide any data or discussion about RSPH10B2. In other words, while the articles illuminate the significance of regulatory and catalytic PKA components (especially PRKAR1A) in diverse physiological and pathological contexts, they do not mention or address the function of the gene RSPH10B2. Thus, based on the available literature provided here, no conclusions can be drawn regarding the molecular role or biological activities of RSPH10B2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "26"}, {"type": "fg_fs", "start_ref": "13", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra C Souza, Kizito V Muliro, Laura Liscum, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cyclic AMP-dependent protein kinase A and CREB are involved in neuregulin-induced synapse-specific expression of acetylcholine receptor gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00660-0"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00660-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12727221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12727221"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mark Veugelers, David Wilkes, Kimberly Burton, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.107.759233"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.107.759233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18316483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18316483"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Georgette N Jones, Chhavy Tep, William H Towns, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq014"}], "href": "https://doi.org/10.1093/hmg/ddq014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20080939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20080939"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ira V Röder, Kyeong-Rock Choi, Markus Reischl, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000980"}], "href": "https://doi.org/10.1371/journal.pgen.1000980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20548949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20548949"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hemal H Patel, Lora L Hamuro, Byeong Jo Chun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.146589"}], "href": "https://doi.org/10.1074/jbc.M110.146589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20581396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20581396"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sam D Molyneux, Marco A Di Grappa, Alexander G Beristain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42391"}], "href": "https://doi.org/10.1172/JCI42391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20697156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20697156"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Diane Moujalled, Ross Weston, Holly Anderton, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Undiagnosed interrupted aortic arch in a 59-year-old male patient with severe aortic valve stenosis: A case report and literature review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ARYA Atheroscler (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25258640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25258640"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Catherine Le Stunff, Francoise Tilotta, Jérémy Sadoine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knock-In of the Recurrent R368X Mutation of PRKAR1A that Represses cAMP-Dependent Protein Kinase A Activation: A Model of Type 1 Acrodysostosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.2987"}], "href": "https://doi.org/10.1002/jbmr.2987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27589370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27589370"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.98394"}], "href": "https://doi.org/10.1172/jci.insight.98394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29367455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29367455"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Marie Helene Schernthaner-Reiter, Giampaolo Trivellin, Thomas Roetzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa178"}], "href": "https://doi.org/10.1093/hmg/ddaa178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32821937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32821937"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yuening Liu, Jingrui Chen, Peng Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100850"}], "href": "https://doi.org/10.1016/j.jbc.2021.100850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34087234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34087234"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kiran S Nadella, Motoyasu Saji, Naduparambil K Jacob, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2009.58"}], "href": "https://doi.org/10.1038/embor.2009.58"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19424295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19424295"}]}]}]}
Proteins R10B2_HUMAN
NCBI Gene ID 728194
API
Download Associations
Predicted Functions View RSPH10B2's ARCHS4 Predicted Functions.
Co-expressed Genes View RSPH10B2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RSPH10B2's ARCHS4 Predicted Functions.

Functional Associations

RSPH10B2 has 1,777 functional associations with biological entities spanning 6 categories (molecular profile, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 49 datasets.

Click the + buttons to view associations for RSPH10B2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RSPH10B2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of RSPH10B2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RSPH10B2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of RSPH10B2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of RSPH10B2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of RSPH10B2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing RSPH10B2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with RSPH10B2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of RSPH10B2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with RSPH10B2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with RSPH10B2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RSPH10B2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RSPH10B2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of RSPH10B2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing RSPH10B2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing RSPH10B2 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of RSPH10B2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RSPH10B2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RSPH10B2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of RSPH10B2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GO Cellular Component Annotations 2025 cellular components containing RSPH10B2 protein from the curated GO Cellular Component Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of RSPH10B2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of RSPH10B2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RSPH10B2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with RSPH10B2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of RSPH10B2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of RSPH10B2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RSPH10B2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of RSPH10B2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of RSPH10B2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of RSPH10B2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of RSPH10B2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of RSPH10B2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of RSPH10B2 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing RSPH10B2 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for RSPH10B2 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RSPH10B2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of RSPH10B2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RSPH10B2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RSPH10B2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of RSPH10B2 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RSPH10B2 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RSPH10B2 gene from the RummaGEO Gene Perturbation Signatures dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of RSPH10B2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of RSPH10B2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of RSPH10B2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of RSPH10B2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of RSPH10B2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with RSPH10B2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.