RTL3 Gene

Name retrotransposon Gag like 3
Description This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. [provided by RefSeq, Nov 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLysyl oxidase‐like 4 (LOXL4) is a member of the lysyl oxidase family that catalyzes the formation of covalent cross-links in collagen, thereby playing a key role in remodeling the extracellular matrix. In breast cancer, particularly in triple‐negative subtypes, reduction of LOXL4 expression has been linked to augmented collagen synthesis and deposition, notably increasing collagen I and IV levels, thickening collagen bundles, and promoting extracellular matrix alterations. These changes contribute to enhanced primary tumor growth and lung metastasis, and low LOXL4 expression is further associated with poorer overall survival in breast cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, investigations into thoracic aortic aneurysm and dissection (TAAD) have revealed that although several LOXL4 variants were identified in affected patients, genetic abrogation of LOXL4 in a mouse model did not lead to an increased severity of angiotensin II-induced aortic aneurysm. This finding suggests that LOXL4 may not play a pivotal role in the pathogenesis of TAAD, underscoring its tissue- and context-dependent functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sul Ki Choi, Hoe Suk Kim, Tiefeng Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14450"}], "href": "https://doi.org/10.18632/oncotarget.14450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28060764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28060764"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huimin Li, Jun Guo, Yiting Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12040513"}], "href": "https://doi.org/10.3390/genes12040513"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33807332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33807332"}]}]}]}
NCBI Gene ID 203430
API
Download Associations
Predicted Functions View RTL3's ARCHS4 Predicted Functions.
Co-expressed Genes View RTL3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RTL3's ARCHS4 Predicted Functions.

Functional Associations

RTL3 has 530 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 15 datasets.

Click the + buttons to view associations for RTL3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RTL3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with RTL3 gene from the CellMarker Gene-Cell Type Associations dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of RTL3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with RTL3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with RTL3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of RTL3 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of RTL3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by RTL3 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of RTL3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of RTL3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of RTL3 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of RTL3 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RTL3 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RTL3 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with RTL3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.