| Name | retrotransposon Gag like 8B |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRTL8B is a small, 13 kDa protein that was identified as a novel interactor of UBQLN2, a ubiquitin adaptor implicated in protein quality control. Under both basal conditions and cellular stress (such as heat shock), RTL8B localizes predominantly to the nucleoli where it actively recruits UBQLN2 from the cytoplasm into distinct subnuclear compartments enriched with ubiquitin and other protein quality control components. This interaction is selective, as RTL8B does not promote the nuclear translocation of other related UBQLNs, such as UBQLN1 or UBQLN4, and in turn, UBQLN2 preferentially stabilizes RTL8B levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe recruitment of UBQLN2 by RTL8B to specific nuclear domains suggests an important role for RTL8B in the regulation of nuclear protein quality control pathways. Given the association of UBQLN2 with neurodegenerative disorders, including ALS/FTD and Huntington’s disease, the RTL8B-mediated regulation of UBQLN2 localization and stability may represent a key mechanism underlying the clearance of aberrant nuclear proteins in these conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Harihar Milaganur Mohan, Hanna Trzeciakiewicz, Amit Pithadia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-022-04170-z"}], "href": "https://doi.org/10.1007/s00018-022-04170-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35247097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35247097"}]}]}]}
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| NCBI Gene ID | 441518 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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RTL8B has 850 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 17 datasets.
Click the + buttons to view associations for RTL8B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RTL8B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with RTL8B gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of RTL8B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of RTL8B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with RTL8B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by RTL8B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RTL8B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of RTL8B gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of RTL8B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of RTL8B gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of RTL8B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of RTL8B gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of RTL8B gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RTL8B gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RTL8B gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RTL8B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with RTL8B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |