{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRUSC1‐AS1 is increasingly recognized as an oncogenic long noncoding RNA, with dysregulated expression observed in several cancers. In cervical cancer, RUSC1‐AS1 is highly expressed and its elevated levels correlate with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and poorer overall survival. Functional experiments revealed that silencing of RUSC1‐AS1 suppressed cell proliferation, migration, and invasion, while inducing apoptosis and inhibiting tumor growth in vivo. Mechanistically, RUSC1‐AS1 acts as a competing endogenous RNA by sponging microRNA‐744, which results in increased expression of the anti‐apoptotic protein Bcl-2, thereby contributing to cancer aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis, RUSC1‐AS1 has been implicated in the development of hepatocellular carcinoma (HCC). In HCC tissues and cell lines, its upregulation is associated with enhanced cell proliferation and reduced apoptosis. Mechanistic assays demonstrated that RUSC1‐AS1 directly binds to hsa-miR-7-5p, leading to the derepression of NOTCH3 and subsequent activation of the NOTCH signaling pathway—a cascade that further supports tumor cell growth and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Furthermore, in breast cancer, RUSC1‐AS1 is similarly overexpressed, suggesting its potential utility as a biomarker. However, the precise biological role and underlying molecular mechanisms by which RUSC1‐AS1 contributes to breast cancer progression require further elucidation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qizhen Guo, Qin Zhang, Lianwei Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RUSC1-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " promotes tumorigenesis in cervical cancer by acting as a competing endogenous RNA of microRNA-744 and consequently increasing Bcl-2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1749468"}], "href": "https://doi.org/10.1080/15384101.2020.1749468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32264732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32264732"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y A Chen, L Cheng, Y Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RUSC1-AS1 promotes the proliferation of hepatocellular carcinoma cells through modulating NOTCH signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2020_191010N1024"}], "href": "https://doi.org/10.4149/neo_2020_191010N1024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32701359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32701359"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aisikeer Ayoufu, Puerkaiti Paierhati, Lei Qiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUSC1-AS1 promotes the malignant progression of breast cancer depending on the regulation of the miR-326/XRCC5 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.15035"}], "href": "https://doi.org/10.1111/1759-7714.15035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37429610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37429610"}]}]}]}